Medication interaction hub

What Supplements Interact with Hydrochlorothiazide, Labetalol?

Hydrochlorothiazide, Labetalol brand name: Trandate HCT. Every interaction below applies to the brands too.

265 Interactions 13 Major 228 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrochlorothiazide, Labetalol? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrochlorothiazide, Labetalol against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Most people on Trandate HCT (hydrochlorothiazide with labetalol) are treating blood pressure for the long haul, often alongside calcium for bones or herbal wellness products, and that overlap is exactly where this list turns serious. Most of its 265 interacting ingredients either lower blood pressure beyond what was intended or pile on diuretic effects that unsettle potassium, calcium, and fluid balance. Thirteen rate major and deserve attention first: dolomite can push calcium dangerously high alongside a thiazide, and activated charcoal can block the drug from being absorbed at all.

The other 228 rate moderate and 24 minor, mostly gentler versions of those same pressure and fluid effects. Alcohol also sits among the majors for added liver strain, one of 38 ingredients flagged for that risk. And 20 moderate entries, bergamot oil included, make skin burn faster in the sun, something few people would connect to a blood pressure pill.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 228 Minor 24 No known interaction 1,187

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrochlorothiazide, Labetalol: Top Interactions at a Glance

The Hydrochlorothiazide, Labetalol supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 265 interacting ingredients — plus 1,187 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrochlorothiazide, Labetalol Combinations Today

The Hydrochlorothiazide, Labetalol + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Birch + Hydrochlorothiazide, Labetaloli

Theoretically, birch might interfere with diuretic therapy.

Read the full interaction Moderate Likelihood Possible Rhubarb + Hydrochlorothiazide, Labetaloli

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Read the full interaction Moderate Likelihood Possible Caffeine + Hydrochlorothiazide, Labetaloli

Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Hydrochlorothiazide, Labetaloli

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Castor Bean + Hydrochlorothiazide, Labetaloli

Theoretically, castor oil might increase the risk of hypokalemia when taken with diuretic drugs.

Read the full interaction Major Likelihood Possible Asarabacca + Hydrochlorothiazide, Labetaloli

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrochlorothiazide, Labetalol

All 1,452 ingredients in our database, ranked by severity — 265 with a Hydrochlorothiazide, Labetalol interaction on file and 1,187 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrochlorothiazide, Labetalol?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Birch with Hydrochlorothiazide, Labetalol?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Hydrochlorothiazide, Labetalol answer

Can you take Rhubarb with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Hydrochlorothiazide, Labetalol answer

Can you take Caffeine with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using caffeine with diuretic drugs might increase the risk of hypokalemia.

Full Caffeine + Hydrochlorothiazide, Labetalol answer

Can you take Ashwagandha with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Hydrochlorothiazide, Labetalol answer

Can you take Castor Bean with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, castor oil might increase the risk of hypokalemia when taken with diuretic drugs.

Full Castor Bean + Hydrochlorothiazide, Labetalol answer

Can you take Black Seed with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Hydrochlorothiazide, Labetalol answer

Can you take Black Tea with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using black tea with diuretic drugs might increase the risk of hypokalemia.

Full Black Tea + Hydrochlorothiazide, Labetalol answer

Can you take Blue Cohosh with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Constituents in blue cohosh might increase blood pressure by causing coronary vasoconstriction.

Full Blue Cohosh + Hydrochlorothiazide, Labetalol answer

Can you take Blue Flag with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Overuse of blue flag might compound diuretic-induced potassium loss.

Full Blue Flag + Hydrochlorothiazide, Labetalol answer

Can you take Boldo with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Hydrochlorothiazide, Labetalol answer

Can you take Breadfruit with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.

Full Breadfruit + Hydrochlorothiazide, Labetalol answer

Can you take Bridelia with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Bridelia extracts decrease arterial pressure.

Full Bridelia + Hydrochlorothiazide, Labetalol answer

Can you take Buchu with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Hydrochlorothiazide, Labetalol answer

Can you take Butternut with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Butternut has stimulant laxative effects.

Full Butternut + Hydrochlorothiazide, Labetalol answer

Can you take Caffeic Acid with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Hydrochlorothiazide, Labetalol answer

Can you take Calamus with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with other antihypertensive medications might increase the risk of hypotension.

Full Calamus + Hydrochlorothiazide, Labetalol answer

Can you take Calotropis with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of calotropis and potassium depleting diuretics can increase the risk of cardiac glycoside toxicity due to po...

Full Calotropis + Hydrochlorothiazide, Labetalol answer

Can you take Camphor with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Hydrochlorothiazide, Labetalol answer

Can you take Canadian Hemp with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Canadian hemp contains cardiac glycosides.

Full Canadian Hemp + Hydrochlorothiazide, Labetalol answer

Can you take Cannabigerol (cbg) with Hydrochlorothiazide, Labetalol?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.

Full Cannabigerol (cbg) + Hydrochlorothiazide, Labetalol answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrochlorothiazide, Labetalol is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrochlorothiazide, Labetalol, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrochlorothiazide, Labetalol sits in 11 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Beta-Blockers 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Hydrochlorothiazide, Labetalol through this category.

Related: does Hydrochlorothiazide, Labetalol deplete any nutrients?

Hydrochlorothiazide, Labetalol has 10 reported nutrient associations in the research literature — see the Hydrochlorothiazide, Labetalol nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrochlorothiazide, Labetalol

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrochlorothiazide, Labetalol.

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Pharmacist Counseling Corner

Hydrochlorothiazide, Labetalol & Supplements: Common Questions

What supplements interact with Hydrochlorothiazide, Labetalol?
In our interaction database, 265 supplement and herbal ingredients have an interaction with Hydrochlorothiazide, Labetalol on file — 13 rated major, 228 moderate, and 24 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Siberian Cocklebur, Tyramine.
Which Hydrochlorothiazide, Labetalol supplement interactions are the most serious?
Focus on the major group: American Hellebore, Siberian Cocklebur, Tyramine, Activated Charcoal and American Mistletoe, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrochlorothiazide, Labetalol?
That depends entirely on which supplement. The honest answer for Hydrochlorothiazide, Labetalol is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Trandate HCT have the same supplement interactions as Hydrochlorothiazide, Labetalol?
Yes — Trandate HCT all contain Hydrochlorothiazide, Labetalol, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Hydrochlorothiazide, Labetalol deplete any vitamins or nutrients?
It might — Hydrochlorothiazide, Labetalol has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Hydrochlorothiazide, Labetalol nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Hydrochlorothiazide, Labetalol and my other medications?
This page covers Hydrochlorothiazide, Labetalol against supplements and herbal ingredients. Checking Hydrochlorothiazide, Labetalol against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.