Drug & supplement interaction

Jequirity + Carvedilol

Carvedilol brand names: Coreg, Coreg CR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Jequirity and Carvedilol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Carvedilol states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Jequirity and Carvedilol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Carvedilol and Jequirity in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Jequirity safety at a glance

Jequirity overall Avoid The seeds contain abrin, a potentially deadly toxin, so jequirity is not safe to take.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Carvedilol and Jequirity? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Carvedilol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Carvedilol is filed under 7 classifications — including beta-blockers, cytochrome p450 2c9 (cyp2c9) substrates, antihypertensive drugs. Jequirity has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (minor) — and none of Carvedilol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Jequirity Does Interact With Other Medications

Jequirity has 208 moderate, 603 minor known drug interactions in our database — Carvedilol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 208 Minor 603 No known interaction 2,019 (incl. Carvedilol)
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Jequirity and Carvedilol May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 4 of them are worth acting on rather than waiting out — marked below.

  • Low potassium / Anemia Worth acting on Additional detail

    Jequirity

    “Orally, jequirity is associated with serious adverse effects. Chewing jequirity seeds or consuming seeds with cracked shells can cause stomach cramping, nausea, vomiting, severe diarrhea (possibly bloody), cold sweats, fever, drowsiness, anxiety, weakness, hypertension, tachycardia, pulmonary edema, kidney failure, liver toxicity, coma, circulatory collapse, cerebral edema, and death.”

    Jequirity · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    2. 5608. Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
    3. 11473. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
    4. 95220. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
    5. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed
    6. 100257. Huang J, Zhang W, Li X, et al. Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report. Medicine (Baltimore). 2017;96(27):e7423. PubMed

    “Iron deficiency anemia, hypocalcemia, hypokalemia, and mild thrombocytosis have been reported in a 2-year old who eventually died after experiencing bloody diarrhea related to consumption of crushed jequirity seeds.”

    Jequirity · Natural Medicines adverse-effect record, reported in anemia.

    1 source cited
    1. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

    Carvedilol

    Listed in the ADVERSE REACTIONS section of the FDA label for Carvedilol. Read the label on DailyMed ›

  • Seizures Worth acting on Additional detail

    Jequirity

    “Orally, jequirity beans can cause cold sweats, fever, drowsiness, anxiety, cerebral edema, coma, increased intracranial pressure, acute demyelinating encephalitis, and seizures.”

    Jequirity · Natural Medicines adverse-effect record, reported in anxiety.

    6 sources cited
    1. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    2. 27025. Sahoo R, Hamide A, Amalnath SD, Narayana BS. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila) 2008;46(10):1071-1073.
    3. 27026. Sahni V, Agarwal SK, Singh NP, Sikdar S. Acute demyelinating encephalitis after jequirity pea ingestion (Abrus precatorius). Clin Toxicol (Phila) 2007;45(1):77-79.
    4. 27027. Subrahmanyan D, Mathew J, Raj M. An unusual manifestation of Abrus precatorius poisoning: a report of two cases. Clin Toxicol (Phila) 2008;46(2):173-175. PubMed
    5. 95220. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
    6. 95221. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

    Carvedilol

    Listed in the ADVERSE REACTIONS section of the FDA label for Carvedilol. Read the label on DailyMed ›

  • Raised blood pressure Worth acting on Additional detail

    Jequirity

    “Orally, chewed or cracked jequirity beans can cause hypertension, tachycardia, or circulatory collapse.”

    Jequirity · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 3499. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
    2. 11473. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed

    Carvedilol

    Listed in the ADVERSE REACTIONS section of the FDA label for Carvedilol. Read the label on DailyMed ›

  • Sweating / Drowsiness / Anxiety or restlessness / Fever / Swelling Additional detail

    Jequirity

    Recorded for Jequirity in the same Natural Medicines adverse-effect record shown under Low potassium / Anemia above.

    Carvedilol

    Listed in the ADVERSE REACTIONS section of the FDA label for Carvedilol. Read the label on DailyMed ›

  • A fast or pounding heartbeat Additional detail

    Jequirity

    Recorded for Jequirity in the same Natural Medicines adverse-effect record shown under Low potassium / Anemia above.

    Carvedilol

    Listed in the ADVERSE REACTIONS section of the FDA label for Carvedilol. Read the label on DailyMed ›

Showing the 10 most notable of 14 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Jequirity but not commonly for Carvedilol: liver problems, kidney problems and dehydration.

Effects for Carvedilol come from the ADVERSE REACTIONS section of its FDA label; effects for Jequirity come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Jequirity in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Carvedilol Products Have a Food Rule — Jequirity Should Not Break It

At least one FDA label for a product containing Carvedilol says to take it with food. If you take Jequirity on an empty stomach out of habit, keep them separate — and take Carvedilol with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Carvedilol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION COREG should be taken with food to slow the rate of absorption and reduce the incidence of orthostatic effects.

From the Dosage and Administration section of the FDA label we read for Carvedilol — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Jequirity or Carvedilol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jequirity or Carvedilol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Carvedilol

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Carvedilol page lists 211 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Grapefruit (major) and Indian Snakeroot (major).

By severity: 6 major · 171 moderate · 34 minor.

From our pharmacist’s overview on the Carvedilol page

“People take carvedilol (Coreg) for heart failure and high blood pressure, conditions where a sudden swing in pressure or heart rate matters, and its supplement list runs to 211 ingredients, so this one calls for genuine care. More than half of those entries lower blood pressure on their own, fish oil and celery seed among them, and can…”

Reviewed by 2 · Jul 18, 2026

Open the Carvedilol interaction page

How much people look this up

Where Jequirity and Carvedilol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Top half

#665 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Carvedilol
Top 10%

#199 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Jequirity reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Jequirity and Carvedilol records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Abrus precatorius · Fabaceae · Seeds, roots, and leaves · Traditional preparations (rarely used today); seeds are sometimes used in jewelry and beadwork

An interaction check asks whether these two react with each other — it does not ask whether Jequirity is a good idea for someone in your situation. Here is what our Jequirity record says about it on its own.

Jequirity: dosing

There is no safe or established dose of jequirity for use as a supplement or medicine. Because the seeds contain a deadly toxin, no amount is considered safe to swallow.We do not recommend taking jequirity in any form.

From our Jequirity monograph — the full record covers uses, side effects and every documented interaction.

Read the full Jequirity monograph & all interactions
Medication

About Carvedilol

What Is Carvedilol Used For?

Brand names: Coreg, Coreg CR

Carvedilol is used to treat three main conditions: mild-to-severe chronic heart failure, high blood pressure (hypertension), and reduced heart pumping function (left ventricular dysfunction) in people who have survived a heart attack. For heart failure, it is usually prescribed alongside other medications such as diuretics, ACE inhibitors, and digitalis to help people live longer and reduce the chance of hospital stays.

For people who have had a heart attack and whose heart is not pumping as well as it should, carvedilol is used to lower the risk of dying from heart-related causes. For high blood pressure, it can be used on its own or combined with other blood pressure medicines.

Most-Reported Side Effects for Carvedilol

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 9,141 reports
Dyspnea 8,542 reports
Diarrhea 7,250 reports
Dizziness 7,211 reports
Nausea 6,830 reports
See full Carvedilol drug information
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
603Minor
2,018No known interaction
208 Moderate 603 Minor 2,018 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Jequirity page.

Minor

603 interactions

Showing 60 of 603 minor interactions — see all 603 on the Jequirity page.

No interaction 2,018 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,018 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Carvedilol, ranked by severity
Evidence & sources

Jequirity References

The 17 references that drive our Jequirity monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Davies JH. Abrus precatorius (rosary pea). The most common lethal plant poison. J Fla Med Assoc 1978;65:188-91.
  3. Kuo SC, Chen SC, Chen LH, et al. Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius. Planta Med 1995;61:307-12.
  4. Niyogi SK. Deadly crab's eye: Abrus precatorius poisoning. N Engl J Med 1969;281:51-2.
  5. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia 2001;56:1178-80. PubMed
  6. Agarwal SS, Ghatak N, Arora RB, Bhardwaj MM. Antifertility activity of the roots of Abrus precatorius, Linn. Pharma Res Comm 1970;2(2):159-163. DOI
  7. Jang DH, Hoffman RS, Nelson LS. Attempted suicide, by mail order: Abrus precatorius. J Med Toxicol 2010;6(4):427-430. PubMed
  8. Nwanjo HU. Hypoglycemic and hypolipidemic effects of aqueous extracts of Abrus precatorius Linn seeds in streptozotocin-induced diabetic Wistar rats. J Herbs Spice Med Plants 2008;14(1-2):68-76.
  9. Sahoo R, Hamide A, Amalnath SD, Narayana BS. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila) 2008;46(10):1071-1073.
  10. Sahni V, Agarwal SK, Singh NP, Sikdar S. Acute demyelinating encephalitis after jequirity pea ingestion (Abrus precatorius). Clin Toxicol (Phila) 2007;45(1):77-79.
  11. Subrahmanyan D, Mathew J, Raj M. An unusual manifestation of Abrus precatorius poisoning: a report of two cases. Clin Toxicol (Phila) 2008;46(2):173-175. PubMed
  12. Somerset EJ. SELF INFLICTED CONJUNCTIVITIS: An account of cases produced by the jequirity and castor oil seeds. Br J Ophthalmol 1945;29(4):196-204. PubMed
  13. Andrews JA. Jequirity Ophthalmia. Trans Am Ophthalmol Soc 1884;3:679-685.
  14. Karthikeyan A, Amalnath SD. Abrus precatorius poisoning: a retrospective study of 112 patients. Indian J Crit Care Med 2017;21(4):224-5.
  15. Patil MM, Patil SV, Akki AS, Lakhkar B, Badiger S. An arrow poison (Abrus precatorius) causing fatal poisoning in a child. J Clin Diagn Res 2016;10(3):SD03-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Jequirity and Carvedilol Together: Common Questions

Is it safe to take Jequirity with Carvedilol?
We do not list a known interaction between Jequirity and Carvedilol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Jequirity and Carvedilol have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Jequirity and Carvedilol at the same time of day?
At least one FDA label for a product containing Carvedilol says to take it with food. If you take Jequirity on an empty stomach out of habit, keep them separate and take Carvedilol with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Carvedilol products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Jequirity and Carvedilol combination checked?
Interactions in our licensed database are recorded against drug classes. Carvedilol is filed under 7 classifications, and Jequirity has documented interactions with 3 drug classes — none of Carvedilol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Jequirity interact with any other medications?
Yes. Jequirity has 811 documented drug interactions in our database — Carvedilol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Carvedilol interact with any supplements?
Yes. Carvedilol has documented interactions with 211 supplements in our database — Jequirity is not one of them. The Carvedilol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Jequirity monograph Uses, safety profile, and every drug interaction in one place Carvedilol drug information The full plain-English guide to this medication Carvedilol supplement interactions Every supplement checked against Carvedilol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Carvedilol and Jequirity?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.