Melatonin + Aspirin, Butalbital, Caffeine, Codeine Phosphate
Aspirin, Butalbital, Caffeine, Codeine Phosphate brand name: Fiorinal w/ Codeine.
Aspirin, Butalbital, Caffeine, Codeine Phosphate falls into 7 drug categories that Melatonin can interact with; the most serious is rated moderate. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full interaction reportMelatonin and Aspirin, Butalbital, Caffeine, Codeine Phosphate
These two interact in 7 distinct ways. Each one is explained separately below.
Why Are There 7 Interactions?
Melatonin interacts with whole categories of medication. Aspirin, Butalbital, Caffeine, Codeine Phosphate falls into 7 of those categories, so it can interact with Melatonin in 7 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 7Why this applies to Aspirin, Butalbital, Caffeine, Codeine Phosphate
Aspirin, Butalbital, Caffeine, Codeine Phosphate falls under CNS DEPRESSANTS — the group Melatonin interacts with.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind with Fiorinal with Codeine: it already carries two ingredients that slow down the brain. Butalbital is a barbiturate, and codeine is an opioid, so this combo can make you drowsy, foggy, and slow on its own. Melatonin also nudges your body toward sleep, so stacking the two could leave you more sedated than you expect, with extra grogginess, dizziness, or trouble concentrating.
This warning is theoretical, meaning it's based on how these things work rather than strong studies, so don't panic. Still, since this medicine genuinely sedates you, I'd play it safe. Chat with your pharmacist or doctor before pairing them, avoid driving until you know how you feel, and skip alcohol on top.
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
SEIZURE THRESHOLD LOWERING DRUGS
2 of 7Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under SEIZURE THRESHOLD LOWERING DRUGS.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Fiorinal with Codeine (a combo of aspirin, butalbital, caffeine, and codeine) and melatonin. This isn't about your liver breaking the medicine down faster or slower. It's a different concern: some drugs can lower the threshold for a seizure, meaning they make seizures a little easier to trigger. Theoretically, melatonin layered on top might nudge that risk up a bit further.
I want to be honest about how soft this evidence is. It's based mostly on pharmacology reasoning, with a little real-world signal in children who have neurological conditions. For most adults using this medication occasionally, it's a low-level, possible concern, not a strong warning. Still, if you or your child have a seizure history, please check with your pharmacist or doctor before combining them.
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
3 of 7Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
This combo pill (Fiorinal with Codeine) mixes several ingredients, and the one that connects to melatonin here is the caffeine. Caffeine is cleared by a liver enzyme called CYP1A2, the same pathway melatonin uses. In theory, taking them together could slow each other down a bit, leaving slightly more caffeine and more melatonin in your system for a while.
What might that feel like? A touch more caffeine could mean extra jitteriness, a racing heart, or trouble falling asleep, which is a little ironic since you may be taking melatonin to rest. On the flip side, higher melatonin levels could leave you groggier. Just so you know, this is a theoretical concern based on how the drugs are processed, not strong real-world proof, so most people do fine. Still, it is worth a quick chat with your pharmacist or doctor before combining them.
- Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. J Pineal Res 1999;26(3):190-191. PubMed
- Faber, M. S., Jetter, A., and Fuhr, U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97(3):125-134. PubMed
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
4 of 7Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece that matters with Fiorinal with Codeine: it contains aspirin, which already thins the blood a bit by making platelets less sticky. Melatonin may have a mild blood-thinning effect of its own, so pairing the two could, in theory, add up and nudge your bleeding risk a little higher. That might look like easier bruising, a nosebleed that takes longer to stop, or stomach upset, since aspirin can irritate the stomach lining on its own.
Honestly, this is a theoretical concern built on a few case reports and small studies, not strong proof. For most people taking occasional melatonin it's likely minor. Still, if you take this regularly, have a bleeding disorder, or notice anything unusual, check in with your pharmacist or doctor first.
- Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;2:CD001520. PubMed
- Wirtz, P. H., Spillmann, M., Bartschi, C., Ehlert, U., and von Kanel, R. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J Pineal Res 2008;44(2):127-133. PubMed
- U.S.Food and Drug Administration. Special Nutritionals Adverse Events Monitoring System: registered case reports.
CAFFEINE
5 of 7Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under CAFFEINE.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the thing to focus on with Fiorinal with Codeine: the piece that interacts with melatonin is the caffeine in the combination. The caffeine and melatonin are both cleared by the same liver enzyme (CYP1A2), so they can sort of compete. The result is that caffeine seems to nudge melatonin levels and effects up a bit, which could leave you feeling a touch sleepier or more drowsy than melatonin alone.
This matters here because the codeine and butalbital in this product are already sedating, so stacking on melatonin may add to the grogginess, slowed thinking, or next-morning hangover feeling. The evidence is modest and somewhat mixed, so don't panic, but if you take both, please check with your pharmacist or doctor first.
- Wright KP Jr, Myers BL, Plenzler SC, et al. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 2000;873:310-7.
- Wright KP Jr, Badia P, Myers BL, et al. Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain Res. 1997;747(1):78-84. PubMed
- Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatonin. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.17252. Epub 2012 Jul 20. PubMed
- Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviat.Space Environ.Med. 2002;73(4):341-350.
- Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406. PubMed
- Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682. PubMed
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
6 of 7Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the wrinkle with this combo. Your Fiorinal product contains codeine, and codeine is a prodrug. That means it doesn't do much on its own. Your body has to convert it (using the liver enzyme CYP2D6) into morphine, which is what actually relieves pain. Lab studies hint that some batches of melatonin might block that same CYP2D6 enzyme.
So if anything, melatonin could mean less codeine getting turned into morphine, which might make the pain relief feel weaker, not stronger. Honestly though, this is theoretical and based only on test-tube research, rated minor, so I wouldn't lose sleep over it. The other pieces (aspirin, butalbital, caffeine) aren't really affected. Just mention it to your pharmacist so they can keep an eye on how well your pain is controlled.
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
7 of 7Aspirin, Butalbital, Caffeine, Codeine Phosphate also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Fiorinal with Codeine, which is a combo of aspirin, butalbital (a barbiturate), caffeine, and codeine. There's a very weak, lab-only signal that certain batches of melatonin might block an enzyme called CYP3A4, which helps process some of these ingredients. In theory, slowing that enzyme could let drug levels creep up a little, which might mean more drowsiness, dizziness, or feeling foggy than usual.
That said, this is theoretical and based only on test-tube research, so I wouldn't lose sleep over it. The bigger real-world concern is simple: both melatonin and this medication can make you sleepy, so stacking them may leave you extra groggy. Please check with your pharmacist or doctor before combining them, rather than changing anything on your own.
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Melatonin Also Interacts With Other Medications
Melatonin has 1,115 moderate, 345 minor known drug interactions in our database — the Aspirin, Butalbital, Caffeine, Codeine Phosphate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Melatonin
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Covers the 2,830 medications we’ve checked against Melatonin. Pick one to open its full report.
Questions About Melatonin or Aspirin, Butalbital, Caffeine, Codeine Phosphate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Melatonin or Aspirin, Butalbital, Caffeine, Codeine Phosphate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is Melatonin Appropriate for a 15-Year-Old to Take for Sleep? ›
- Can You Take Melatonin With Temazepam? ›
- Can You Take Eliquis With Melatonin? ›
- Can You Take Melatonin And Ibuprofen Together? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Aspirin, Butalbital, Caffeine, Codeine Phosphate
This page covers Melatonin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Butalbital, Caffeine, Codeine Phosphate page lists 398 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 17 major · 334 moderate · 47 minor.
From our pharmacist’s overview on the Aspirin, Butalbital, Caffeine, Codeine Phosphate page
“Fiorinal with Codeine packs four active drugs into one capsule, and I would treat its supplement list with genuine wariness rather than a quick skim. The aspirin component is why roughly half of the 398 ingredients on file raise bleeding risk, while the codeine and butalbital explain a second large cluster that deepens sedation, someti…”
Reviewed by 2 · Jul 18, 2026
Open the Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction page
Taking Melatonin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,885 real supplement products containing Melatonin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Melatonin. Your product may carry other ingredients that interact with Aspirin, Butalbital, Caffeine, Codeine Phosphate too, on top of Melatonin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Melatonin and Aspirin, Butalbital, Caffeine, Codeine Phosphate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#55 of 1,452 supplements looked up here in the last 7 days
#1,941 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Melatonin
What is Melatonin?
- Trouble falling asleep (insomnia)
- Jet lag
- Delayed sleep phase syndrome
- Non-24-hour sleep-wake disorder
- Shift-work sleep problems
- Sleep problems in some children with conditions like autism or ADHD
Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is strongest for certain circadian (body-clock) disorders and is more mixed for everyday insomnia. It is generally well tolerated for short-term use, but talk with your pharmacist or doctor before starting, especially for children or during pregnancy.
Other Drugs & Melatonin
Browse every other medication we’ve checked against Melatonin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,115 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Amoxicillin ›
- Hydrochlorothiazide ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Fentanyl ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Amphotericin B ›
- Ampicillin ›
- Carbamazepine ›
- Ceftazidime ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Morphine Sulfate ›
- Nitrazepam ›
- Penicillin G Potassium ›
- Pseudoephedrine ›
- Acetaminophen ›
- Acyclovir ›
- Amphetamine ›
- Baclofen ›
- Buprenorphine ›
Showing 60 of 1,115 moderate interactions — see all 1,115 on the Melatonin page.
345 interactions
- Erythromycin ›
- Norethindrone ›
- Testosterone ›
- Colchicine ›
- Oxybutynin ›
- Budesonide ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Conjugated Estrogens ›
- Everolimus ›
- Ivabradine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Rifampin ›
- Testosterone Undecanoate ›
- Dapsone ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Etoposide ›
- Fluticasone Propionate ›
- Itraconazole ›
- Modafinil ›
- Vortioxetine ›
- Abiraterone Acetate ›
- Almotriptan ›
- Amiodarone ›
- Aprepitant ›
- Budenoside ›
- Cabazitaxel ›
- Clarithromycin ›
- Cocaine Hydrochloride (prescription Drug) ›
- Dasatinib ›
- Dihydroergotamine ›
- Disopyramide Phosphate ›
- Dronabinol ›
- Ergotamine Tartrate (prescription Drug) ›
- Esterified Estrogens ›
- Finasteride ›
- Fluticasone Furoate ›
- Fosamprenavir ›
- Fosaprepitant ›
- Galantamine ›
- Indacaterol ›
- Irinotecan ›
- Lacosamide ›
- Lovastatin ›
- Maraviroc ›
- Mifepristone ›
- Mometasone ›
- Mometasone Furoate ›
- Nevirapine ›
- Paclitaxel ›
- Quinine Sulfate ›
- Ranolazine ›
- Rilpivirine ›
- Roflumilast ›
- Ruxolitinib ›
Showing 60 of 345 minor interactions — see all 345 on the Melatonin page.
No interaction 1,369 drugs checked — show the list
We also checked Melatonin against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Hydroxyurea ›
- Sumatriptan ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Factor 7a ›
- Thyroid Hormone ›
- Mitomycin ›
- Ezetimibe ›
- Phenylephrine ›
- Vancomycin ›
- Lenvatinib ›
- Hethylphenidate Hcl ›
- Dirithromycin ›
- Bentoquatam ›
- Procainamide ›
- Hydroxychloroquine ›
- Azelaic Acid ›
- Triptorelin ›
- Digoxin ›
- Dextrothyroxine ›
- Lomustine ›
- Pizotifen ›
- Tocainide ›
- Rocuronium ›
- Succimer ›
- Mitomycin C ›
- Halothane ›
- Chenodiol ›
- Desflurane ›
- Niacin (prescription Drug) ›
- Digitoxin ›
- Cabergoline ›
- Ranitidine ›
- Caspofungin ›
- Anastrozole ›
- Alendronate ›
- Allopurinol ›
- Salbutamol Sulfate ›
- Ribavirin Aerosol ›
- Naltrexone ›
- Naratriptan ›
- Hydroxyprogesterone ›
- Droxidopa ›
- Flutemetamol F-18 ›
- Calcium Carbonate ›
- Nylidrin ›
- Nicotine ›
Showing the 60 most looked-up of 1,369 medications checked with no known interaction — see the full Melatonin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Butalbital, Caffeine, Codeine Phosphate Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Aspirin, Butalbital, Caffeine, Codeine Phosphate as a medicine that can lower these. This is not an interaction with Melatonin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Butalbital, Caffeine, Codeine Phosphate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Melatonin and Aspirin, Butalbital, Caffeine, Codeine Phosphate Together: Common Questions
Can you take Melatonin with Aspirin, Butalbital, Caffeine, Codeine Phosphate?
Why are there 7 interactions listed for Melatonin and Aspirin, Butalbital, Caffeine, Codeine Phosphate?
How serious is the Melatonin and Aspirin, Butalbital, Caffeine, Codeine Phosphate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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