Melatonin + Aspirin, Caffeine, Dihydrocodeine Bitartrate
Aspirin, Caffeine, Dihydrocodeine Bitartrate brand name: Synalgos DC.
Aspirin, Caffeine, Dihydrocodeine Bitartrate falls into 7 drug categories that Melatonin can interact with; the most serious is rated moderate. Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full interaction reportMelatonin and Aspirin, Caffeine, Dihydrocodeine Bitartrate
These two interact in 7 distinct ways. Each one is explained separately below.
Why Are There 7 Interactions?
Melatonin interacts with whole categories of medication. Aspirin, Caffeine, Dihydrocodeine Bitartrate falls into 7 of those categories, so it can interact with Melatonin in 7 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CNS DEPRESSANTS
1 of 7Why this applies to Aspirin, Caffeine, Dihydrocodeine Bitartrate
Aspirin, Caffeine, Dihydrocodeine Bitartrate falls under CNS DEPRESSANTS — the group Melatonin interacts with.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Synalgos DC contains dihydrocodeine, an opioid pain reliever that can make you drowsy on its own. Melatonin also nudges your body toward sleep. When you combine the two, the worry is simply that their calming, sleepy effects can add up. You might feel more groggy, lightheaded, or slow to react than you'd expect from either one alone, which matters most if you drive or need to stay alert.
Keep in mind this is a theoretical concern based on how these products work, not something proven to cause big problems in most people. The caffeine in this combo may offset some sleepiness too. Still, it's worth a quick chat with your pharmacist or doctor before pairing them, especially when you first start.
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
SEIZURE THRESHOLD LOWERING DRUGS
2 of 7Aspirin, Caffeine, Dihydrocodeine Bitartrate also falls under SEIZURE THRESHOLD LOWERING DRUGS.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
This combination pill (Synalgos DC) pairs aspirin and caffeine with dihydrocodeine, an opioid pain reliever. The concern here is more theoretical than proven. Some medicines, including certain opioids, can slightly lower the threshold at which seizures happen, and on paper, adding melatonin might nudge that risk up a little. Most of the worry comes from reports in children with neurological problems, not healthy adults.
For most people taking this for short-term pain, occasional melatonin is unlikely to cause trouble. But both can make you drowsy, so together you may feel extra sleepy or foggy. If you have a seizure disorder or take seizure medicines, check with your pharmacist or doctor before combining these. Don't stop anything on your own.
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
3 of 7Aspirin, Caffeine, Dihydrocodeine Bitartrate also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
In this combination product (Synalgos DC), the ingredient that actually interacts with melatonin here is the caffeine. Caffeine is cleared by the liver enzyme CYP1A2, and on paper melatonin could slow that enzyme a little. If caffeine hangs around longer, you might feel more of its effects: jitteriness, a racing heartbeat, or trouble settling down at night, which is a bit counterproductive when you're using melatonin to sleep. Interestingly, caffeine can also slow melatonin's breakdown, so each may bump the other up slightly.
Honestly, this is a theoretical interaction based on how these drugs are processed, not strong real-world reports. For most people it's minor. Still, if you notice extra restlessness, mention it to your pharmacist or doctor before changing anything.
- Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. J Pineal Res 1999;26(3):190-191. PubMed
- Faber, M. S., Jetter, A., and Fuhr, U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97(3):125-134. PubMed
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
4 of 7Aspirin, Caffeine, Dihydrocodeine Bitartrate also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the piece that matters for Synalgos DC: it contains aspirin, which thins the blood a little by making your platelets less sticky. Melatonin may have a mild blood-thinning effect of its own, so pairing the two could, in theory, add up and raise your chance of bleeding or bruising. Think along the lines of nosebleeds that take a while to stop, easy bruising, bleeding gums, or, less often, stomach bleeding (dark or tarry stools).
I want to be honest about the strength of this: it's mostly theoretical, with only a few scattered case reports, and they involved warfarin rather than aspirin. So this isn't a reason to panic. Still, keep an eye out for unusual bruising or bleeding, and check with your pharmacist or doctor before combining them, especially if you already bleed easily.
- Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;2:CD001520. PubMed
- Wirtz, P. H., Spillmann, M., Bartschi, C., Ehlert, U., and von Kanel, R. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J Pineal Res 2008;44(2):127-133. PubMed
- U.S.Food and Drug Administration. Special Nutritionals Adverse Events Monitoring System: registered case reports.
CAFFEINE
5 of 7Aspirin, Caffeine, Dihydrocodeine Bitartrate also falls under CAFFEINE.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the thing to know about Synalgos DC: it contains caffeine alongside the aspirin and dihydrocodeine. That caffeine is the piece that talks to melatonin. Both are handled by the same liver enzyme (CYP1A2), so when you take them together, the caffeine can slow how fast your body clears melatonin. The practical result is that your melatonin may hang around longer and feel a bit stronger.
In real life this usually just means more grogginess, deeper drowsiness, or feeling groggy the next morning, which can stack on top of the sleepiness dihydrocodeine already causes. The evidence here is modest and the effect is mild for most people, but if you feel unusually drowsy or foggy, mention it to your pharmacist or doctor before changing anything.
- Wright KP Jr, Myers BL, Plenzler SC, et al. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 2000;873:310-7.
- Wright KP Jr, Badia P, Myers BL, et al. Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain Res. 1997;747(1):78-84. PubMed
- Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatonin. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.17252. Epub 2012 Jul 20. PubMed
- Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviat.Space Environ.Med. 2002;73(4):341-350.
- Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406. PubMed
- Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682. PubMed
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
6 of 7Aspirin, Caffeine, Dihydrocodeine Bitartrate also falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the wrinkle with this one. The dihydrocodeine in Synalgos DC is a prodrug, meaning your body relies on the liver enzyme CYP2D6 to turn it into its more active, pain-relieving form. Some lab samples of melatonin appear to mildly slow that same enzyme. In theory, that could mean dihydrocodeine is converted a little less efficiently, which might translate to slightly weaker pain relief rather than more side effects.
That said, I want to be honest about how thin this evidence is. This comes only from test-tube research, the interaction is rated minor, and many people take both with no noticeable problem. You don't need to panic or stop anything. If your pain control feels off, just mention the melatonin to your pharmacist or doctor so they can keep an eye on it.
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
7 of 7Aspirin, Caffeine, Dihydrocodeine Bitartrate also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with Synalgos DC (aspirin, caffeine, and dihydrocodeine) plus melatonin. Some lab samples of melatonin appear to slow down a liver enzyme called CYP3A4. In theory, that could let certain drugs build up a bit. The dihydrocodeine piece is partly handled by this enzyme, so if it cleared more slowly you might feel a touch more of the usual opioid effects, like extra drowsiness, lightheadedness, or constipation. Melatonin itself can also make you sleepy, which adds to that.
That said, this is theoretical and comes only from lab work, not real patients, and it's rated minor. For most people it's not a big deal. Still, since both can cause sedation, go easy and check with your pharmacist or doctor before combining them.
- Foster BC, Cvijovic K, Boon HS, et al. Melatonin Interaction Resulting in Severe Sedation. J Pharm Pharm Sci 2015;18(2):124-31. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Melatonin Also Interacts With Other Medications
Melatonin has 1,115 moderate, 345 minor known drug interactions in our database — the Aspirin, Caffeine, Dihydrocodeine Bitartrate one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Melatonin
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Covers the 2,830 medications we’ve checked against Melatonin. Pick one to open its full report.
Questions About Melatonin or Aspirin, Caffeine, Dihydrocodeine Bitartrate
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Melatonin or Aspirin, Caffeine, Dihydrocodeine Bitartrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is Melatonin Appropriate for a 15-Year-Old to Take for Sleep? ›
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- Can You Take Melatonin And Ibuprofen Together? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Aspirin, Caffeine, Dihydrocodeine Bitartrate
This page covers Melatonin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Dihydrocodeine Bitartrate page lists 398 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).
By severity: 17 major · 334 moderate · 47 minor.
Open the Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction page
Taking Melatonin as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,885 real supplement products containing Melatonin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Melatonin. Your product may carry other ingredients that interact with Aspirin, Caffeine, Dihydrocodeine Bitartrate too, on top of Melatonin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Melatonin and Aspirin, Caffeine, Dihydrocodeine Bitartrate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#55 of 1,452 supplements looked up here in the last 7 days
#1,540 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Melatonin
What is Melatonin?
- Trouble falling asleep (insomnia)
- Jet lag
- Delayed sleep phase syndrome
- Non-24-hour sleep-wake disorder
- Shift-work sleep problems
- Sleep problems in some children with conditions like autism or ADHD
Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is strongest for certain circadian (body-clock) disorders and is more mixed for everyday insomnia. It is generally well tolerated for short-term use, but talk with your pharmacist or doctor before starting, especially for children or during pregnancy.
Other Drugs & Melatonin
Browse every other medication we’ve checked against Melatonin — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,115 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Diphenhydramine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Amoxicillin ›
- Hydrochlorothiazide ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Flurazepam ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Bupropion ›
- Chloroquine ›
- Ciprofloxacin ›
- Fentanyl ›
- Oxycodone ›
- Penicillin V Potassium ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Amphotericin B ›
- Ampicillin ›
- Carbamazepine ›
- Ceftazidime ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Formoterol ›
- Hydralazine ›
- Indomethacin ›
- Insulin (human) ›
- Morphine Sulfate ›
- Nitrazepam ›
- Penicillin G Potassium ›
- Pseudoephedrine ›
- Acetaminophen ›
- Acyclovir ›
- Amphetamine ›
- Baclofen ›
- Buprenorphine ›
Showing 60 of 1,115 moderate interactions — see all 1,115 on the Melatonin page.
345 interactions
- Erythromycin ›
- Norethindrone ›
- Testosterone ›
- Colchicine ›
- Oxybutynin ›
- Budesonide ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Conjugated Estrogens ›
- Everolimus ›
- Ivabradine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Rifampin ›
- Testosterone Undecanoate ›
- Dapsone ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Etoposide ›
- Fluticasone Propionate ›
- Itraconazole ›
- Modafinil ›
- Vortioxetine ›
- Abiraterone Acetate ›
- Almotriptan ›
- Amiodarone ›
- Aprepitant ›
- Budenoside ›
- Cabazitaxel ›
- Clarithromycin ›
- Cocaine Hydrochloride (prescription Drug) ›
- Dasatinib ›
- Dihydroergotamine ›
- Disopyramide Phosphate ›
- Dronabinol ›
- Ergotamine Tartrate (prescription Drug) ›
- Esterified Estrogens ›
- Finasteride ›
- Fluticasone Furoate ›
- Fosamprenavir ›
- Fosaprepitant ›
- Galantamine ›
- Indacaterol ›
- Irinotecan ›
- Lacosamide ›
- Lovastatin ›
- Maraviroc ›
- Mifepristone ›
- Mometasone ›
- Mometasone Furoate ›
- Nevirapine ›
- Paclitaxel ›
- Quinine Sulfate ›
- Ranolazine ›
- Rilpivirine ›
- Roflumilast ›
- Ruxolitinib ›
Showing 60 of 345 minor interactions — see all 345 on the Melatonin page.
No interaction 1,369 drugs checked — show the list
We also checked Melatonin against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Hydroxyurea ›
- Sumatriptan ›
- Azithromycin ›
- Isotretinoin ›
- Methylene Blue ›
- Levothyroxine, Liothyronine ›
- Cyclopentolate ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Daptomycin ›
- Hexobarbitone ›
- Levothyroxine Sodium ›
- Factor 7a ›
- Thyroid Hormone ›
- Mitomycin ›
- Ezetimibe ›
- Lenvatinib ›
- Phenylephrine ›
- Vancomycin ›
- Hethylphenidate Hcl ›
- Dirithromycin ›
- Bentoquatam ›
- Procainamide ›
- Hydroxychloroquine ›
- Digoxin ›
- Azelaic Acid ›
- Dextrothyroxine ›
- Triptorelin ›
- Lomustine ›
- Tocainide ›
- Pizotifen ›
- Rocuronium ›
- Succimer ›
- Mitomycin C ›
- Halothane ›
- Chenodiol ›
- Desflurane ›
- Niacin (prescription Drug) ›
- Caspofungin ›
- Ranitidine ›
- Cabergoline ›
- Anastrozole ›
- Allopurinol ›
- Salbutamol Sulfate ›
- Alendronate ›
- Naltrexone ›
- Naratriptan ›
- Hydroxyprogesterone ›
- Droxidopa ›
- Ribavirin Aerosol ›
- Nicotine ›
- Bethanechol Chloride ›
- Fam-trastuzumab, Deruxtecan-nxki ›
- Calcium Carbonate ›
- Protriptyline ›
Showing the 60 most looked-up of 1,369 medications checked with no known interaction — see the full Melatonin list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Aspirin, Caffeine, Dihydrocodeine Bitartrate Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Aspirin, Caffeine, Dihydrocodeine Bitartrate as a medicine that can lower these. This is not an interaction with Melatonin — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Aspirin, Caffeine, Dihydrocodeine Bitartrate nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Melatonin and Aspirin, Caffeine, Dihydrocodeine Bitartrate Together: Common Questions
Can you take Melatonin with Aspirin, Caffeine, Dihydrocodeine Bitartrate?
Why are there 7 interactions listed for Melatonin and Aspirin, Caffeine, Dihydrocodeine Bitartrate?
How serious is the Melatonin and Aspirin, Caffeine, Dihydrocodeine Bitartrate interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.