Herb & supplement monograph

Nutmeg Drug Interactions, Uses, Effectiveness, Safety & More

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Reviewed by licensed pharmacists Sourced from Natural Medicines

Nutmeg Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Nutmeg drug interaction appears low for most people, since nearly all reported concerns come from animal or lab research rather than human studies. None of the listed interactions are rated major, and every one rests on theoretical or animal evidence rather than confirmed effects in people.

Interactions deserving the most attention

The interaction with the strongest support involves phenobarbital, a seizure medicine, where animal studies conflict on whether nutmeg strengthens or weakens its effects; any shift could matter for seizure control. Nutmeg oils have shown sedative effects in animals, so combining it with CNS depressants such as sleep aids or sedatives could, in theory, add to drowsiness. Nutmeg may also affect acetylcholine, a chemical some medicines for memory, bladder, or bowel conditions work through, which could alter how those drugs perform.

What the rest of the list means

The long list of medications reflects a handful of theoretical mechanisms applied broadly, not hundreds of proven problems. Most entries are based on animal findings, including a possible effect on an enzyme the body uses to clear certain medications, and none of these predicted effects has been confirmed to cause meaningful changes in people.

Check your medications against Nutmeg

Based on HelloPharmacist’s Nutmeg interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Nutmeg

528 medications have a known interaction with Nutmeg, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcepromazineAtravet› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief› Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength› Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG› Acetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid› Acetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR› Acetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule› Acetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus› Acetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more› Acetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Nutmeg combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Nutmeg affects

Every type of medication (drug category) Nutmeg is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 5 drug categories Nutmeg interacts with
Anticholinergic DrugsCholinergic DrugsCns DepressantsCytochrome P450 1a2 (cyp1a2) SubstratesPhenobarbital (luminal)
Anticholinergic Drugs

Theoretically, concomitant use of nutmeg and anticholinergic drugs might decrease the effectiveness of either agent.
Animal research suggests that nutmeg extract can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concomitant use of nutmeg with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Animal research suggests that nutmeg extract can inhibit acetylcholinesterase and might increase acetylcholine levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, nutmeg might increase the risk of additive sedation when taken with CNS depressants.
Animal studies suggest that nutmeg extracts and several volatile oils in nutmeg, such as methyleugenol, isoeugenol, safrole, myristicin, trimyristin, 1,8-cineole, and geranyl acetate, have sedative effects. One animal study shows that petroleum ether extracts of nutmeg can potentiate the effects of pentobarbital or phenobarbital. However, evidence from other animal research suggests that the nutmeg constituent myristicin can actually reduce sleeping time in rats pretreated with phenobarbital.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.
Animal research suggests that intraperitoneal injections of myristicin, a constituent of nutmeg, can induce CYP1A2.

Likelihood Possible Evidence D
Phenobarbital (Luminal)

Theoretically, nutmeg might increase or decrease the effects and adverse effects of phenobarbital.
Some animal research suggests that myristicin, a constituent of nutmeg, can reduce sleeping time in rats pretreated with phenobarbital. However, other animal research suggests that petroleum ether extract of nutmeg can potentiate the effects of phenobarbital.

Likelihood Probable Evidence D
Monograph

Nutmeg: Uses, Safety & Side Effects

The bottom line

Nutmeg is a popular cooking spice that has long been used in traditional medicine for digestion and other complaints, but there is little solid human research to support its medicinal use. In normal cooking amounts it is generally safe, but larger "medicinal" doses can cause serious poisoning, so it should never be taken in high amounts.

Nutmeg
Scientific name
Myristica fragrans
Family
Myristicaceae
Part used
Seed (nutmeg), seed covering (mace), and essential oil
Common forms
Whole or ground spice, powder, capsules, essential oil
People commonly use it for
  • Digestive upset
  • Diarrhea
  • Sleep and relaxation
  • Pain and inflammation
  • Flavoring spice

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Safe as a food spice, but larger doses can be toxic and cause serious poisoning.

PregnancyLikely Safe

When used orally and appropriately in amounts commonly found in foods.

Read the full pregnancy detail
BreastfeedingLikely Safe

When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of nutmeg...

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Nutmeg is a warm, aromatic spice made from the seed of the nutmeg tree (Myristica fragrans), an evergreen tree native to Indonesia and the Spice Islands. The same seed produces two spices: nutmeg comes from the inner seed, while mace comes from the lacy red covering around it. The tree is now also grown in other tropical regions, such as the Caribbean.

For centuries, nutmeg has been used in cooking around the world and in traditional medicine systems. People have used it for digestive complaints, to help with sleep, and as a flavoring. Today it is most often used simply as a kitchen spice, but it is also sold as a powder, in capsules, and as an essential oil.

How it works

Nutmeg contains a number of natural compounds, including myristicin, elemicin, and various essential oils, along with antioxidants. In laboratory and animal studies, some of these compounds have shown antioxidant, anti-inflammatory, and antimicrobial activity.

Myristicin is also the compound thought to be responsible for nutmeg's mind-altering and toxic effects when taken in large amounts. It is believed to affect the nervous system, which may partly explain both its traditional calming use and its danger in high doses.

It is important to remember that most of this research is preliminary and done in test tubes or animals. These findings do not prove that nutmeg works the same way in the human body at safe doses.

Effectiveness

Does Nutmeg work?

Evidence overview · 3 uses evaluated
3 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Nutmeg, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 3 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Dental caries
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical nutmeg is beneficial in children with dental caries.

Insufficient Reliable Evidence To Rate Diarrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral nutmeg for diarrhea, there is insufficient reliable information about the clinical effects of nutmeg for this purpose.

Insufficient Reliable Evidence To Rate Halitosis
Rating & evidence shown verbatim from Natural Medicines

It is unclear if nutmeg is beneficial for halitosis.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Used in normal cooking amounts, nutmeg is generally considered safe for most people. The main concern is with larger "medicinal" or recreational doses. Eating just a couple of teaspoons or more can cause nutmeg poisoning, which can be serious.

Symptoms of nutmeg poisoning can include nausea, vomiting, dizziness, a fast or irregular heartbeat, confusion, hallucinations, dry mouth, and a feeling of dread. These effects can last many hours and, in rare cases, can be dangerous. People sometimes try nutmeg as a cheap intoxicant, which is unsafe and not recommended.

Pregnancy: Avoid medicinal or large amounts of nutmeg during pregnancy, as it may be harmful. Normal food seasoning is generally considered acceptable, but do not use it as a remedy.

Breastfeeding: Food amounts are likely fine, but there is not enough safety information to recommend concentrated supplements or large doses while breastfeeding.

People with liver problems, those taking multiple medications, and older adults should be especially careful. Always talk with your pharmacist or doctor before using nutmeg as a supplement.

Side effects

In small food amounts, nutmeg rarely causes problems. In larger doses, side effects can include nausea, vomiting, dizziness, dry mouth, rapid heartbeat, agitation, confusion, and hallucinations.

Severe nutmeg poisoning, though uncommon, can require emergency medical care. If you or someone else has taken a large amount of nutmeg and feels very unwell, seek medical help or contact a poison control center right away.

Nutmeg: Reported Adverse Effects

Documented safety reports on Nutmeg from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, nutmeg is generally well tolerated when used as a spice in foods. Acute or chronic use of nutmeg at high doses is unsafe.

Most Common Adverse Effects:

Topically: Allergic contact dermatitis in sensitive individuals.

Serious Adverse Effects (Rare):

Orally: Accidental or intentional overdose with nutmeg has been associated with several serious adverse cardiovascular, gastrointestinal, neurological, and psychiatric events. Death due to overdose has also been reported.

Reports by condition
Anxiety Psychiatric

Orally, visual, auditory, and tactile hallucinations, depression, suicidal ideation, insomnia, restlessness, and bizarre behavior have been reported following nutmeg intoxication in various reports. Other adverse effects associated with high intake of nutmeg have included disorientation, stupor, euphoria, anxiety, and agitation. Chronic psychosis has been associated with rare cases of prolonged abuse of nutmeg. However, some researchers suggest that nutmeg does not have significant psychological or behavioral effects, even when taken at high doses. Restlessness and anxiety have been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8.
  3. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90.
  4. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30.
  5. Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46.
  6. Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996.
  7. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80.
  8. Atherton RR. The 'Nutmeg Challenge': a dangerous social media trend. Arch Dis Child. 2020:archdischild-2020-319407.
  9. Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol. 1994;42(2):117-24.
  10. Beattie RT. Nutmeg as a psychoactive agent. Br J Addict Alcohol Other Drugs. 1968;63(1):105-9.
Cluster headache Neurologic/CNS

Orally, headache, dizziness, and drowsiness were reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis. Adverse effects associated with high intake of nutmeg have included confusion, dizziness, drowsiness, hallucinations, headache, incoherent speech, hot and cold sensations, sensations of limb loss, convulsions, and coma. Sweating and hypothermia have also been reported following intake of high doses of nutmeg. Lethargy has been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder.

  1. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8.
  2. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754.
  3. Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6.
  4. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90.
  5. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96.
  6. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80.
  7. Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90.
  8. Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46.
  9. Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996.
  10. Medagoda K. A family with nutmeg poisoning due to a home-made 'Covid treatment syrup'. Natl Med J India 2022;35(3):187.
  11. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1.
Dermatitis Immunologic
Diarrhea Gastrointestinal

Orally, nausea was reported in a 13-year-old female consuming nutmeg capsules while smoking cannabis. Vomiting was reported in a case of a 19-year-old female using high doses of nutmeg with a history of lysergic acid diethylamide (LSD) and cannabis use. Burning epigastric pain, gastroenteritis, diarrhea, nausea, and increased thirst have been reported in other cases of intentional or unintentional nutmeg overdose. Vomiting has been reported in a 17-year-old male who snorted at least 15 grams of nutmeg powder.

  1. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8.
  2. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754.
  3. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1.
  4. Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6.
  5. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90.
  6. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80.
  7. Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90.
  8. Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46.
  9. Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996.
Hyponatremia Hematologic

Orally, hyponatremia and leukocytosis with neutrophilia associated with nutmeg overdose have been rarely reported.

  1. Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46.
Hypotension Cardiovascular

Orally, in cases of nutmeg overdose, tachycardia, palpitations, weak pulse, hypotension, and nonspecific electrocardiographic changes have been reported.

  1. Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.
  2. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1.
  3. Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22:223-5.
  4. Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6.
  5. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90.
  6. Shah AM, Calello DP, Quintero-Solivan J, Osterhoudt KC. The not-so-nice spice: a teenage girl with palpitations and dry mouth. Pediatr Emerg Care 2011;27:1205-7.
  7. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80.
  8. Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9.
  9. Beckerman B, Persaud H. Nutmeg overdose: Spice not so nice. Complement Ther Med. 2019;46:44-46.
  10. Reynoard J, Torrents R, Domange B, Glaizal M, de Haro L, Simon N. Nutmeg poisoning: Ten years (2008-2018) of experience from the Marseille Poison Control Center. Presse Med. 2019;48(9):994-996.
  11. Medagoda K. A family with nutmeg poisoning due to a home-made 'Covid treatment syrup'. Natl Med J India 2022;35(3):187.
Poisoning Other
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no well-established medicinal dose for nutmeg, and no standardized supplement dose has been proven safe and effective for any health condition. As a spice, the small amounts used in cooking are considered safe.

Because the line between a flavoring amount and a toxic amount is not very wide, you should not take large doses of nutmeg for health purposes. If you choose to use a nutmeg supplement, follow the product label exactly and check with your pharmacist or doctor first.

Pregnancy & Breastfeeding

Nutmeg & Pregnancy

Likely Safe

When used orally and appropriately in amounts commonly found in foods.

Possibly Unsafe

When used orally in medicinal amounts. Nutmeg might have abortifacient activity, and its safrole content might be mutagenic.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Nutmeg & Breastfeeding

Likely Safe

When used orally and appropriately in amounts commonly found in foods. There is insufficient reliable information available about the safety of nutmeg when used in larger, medicinal amounts during lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 29 references that drive our Nutmeg monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
  3. Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
  4. Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
  5. Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.
  6. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
  7. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
  8. Demetriades AK, Wallman PD, McGuiness A, Gavalas MC. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22:223-5. PubMed
  9. Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24:563-6. PubMed
  10. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
  11. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
  12. Shah AM, Calello DP, Quintero-Solivan J, Osterhoudt KC. The not-so-nice spice: a teenage girl with palpitations and dry mouth. Pediatr Emerg Care 2011;27:1205-7. PubMed
  13. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
  14. Williams EY, West F. The use of nutmeg as a psychotropic drug. Report of two cases. J Natl Med Assoc 1968;60:289-90.
  15. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Nutmeg

194 products in our database contain Nutmeg. Open any to see its full ingredient list and every drug interaction we check.

#Shatter SX-7 Black Onyx Fruit Punch Explosion by MuscleTech Powder 12.15 Oz(s) · 345 Gram(s) View ingredients & interactions #Shatter SX-7 Black Onyx Icy Rocket Freeze by MuscleTech Powder 12.2 oz. · 346 Gram(s) View ingredients & interactions #Shatter SX-7 Black Onyx Neuro Watermelon Fusion by MuscleTech Powder 11.31 oz. · 321 Gram(s) View ingredients & interactions #Shatter SX-7 Black Onyx Ripped Cherry Limeade Twist by MuscleTech Powder 16.79 oz. · 476 Gram(s) View ingredients & interactions #Shatter SX-7 Blue Raspberry Explosion by MuscleTech Powder 6.12 oz. · 174 Gram(s) View ingredients & interactions #Shatter SX-7 Blue Raspberry Explosion by MuscleTech Powder 10.27 oz. · 291 Gram(s) View ingredients & interactions #Shatter SX-7 Fruit Punch Blast by MuscleTech Powder 10.27 oz. · 291 Gram(s) View ingredients & interactions #Shatter SX-7 Fruit Punch Blast by MuscleTech Powder 6.12 oz. · 174 Gram(s) View ingredients & interactions #Shatter SX-7 Icy Pink Lemonade by MuscleTech Powder 6.12 oz. · 174 Gram(s) View ingredients & interactions #Shatter SX-7 Icy Pink Lemonade by MuscleTech Powder 10.27 oz. · 291 Gram(s) View ingredients & interactions #Shatter SX-7 Watermelon Fusion by MuscleTech Powder 6.12 oz. · 174 Gram(s) View ingredients & interactions #Shatter SX-7 Watermelon Fusion by MuscleTech Powder 10.27 oz. · 291 Gram(s) View ingredients & interactions Aloe 22 by Health Concerns Capsule 90 Capsule(s) View ingredients & interactions Aloe 22 by Health Concerns Tablet Or Pill 90 Tablet(s) View ingredients & interactions Amla Plus by R-U-Ved Powder 10.6 oz. · 300 Gram(s) View ingredients & interactions Apple Cider Vinegar by BioSchwartz Capsule 60 Veggie Cap(s) View ingredients & interactions Ashwagandha Rasayana 9a by Ayurvedic Rasayanas Other (e.g. Tea Bag) 10.7 Ounce(s) · 300 Gram(s) View ingredients & interactions Baby Nighttime Cough Syrup by Maty's Liquid 2 Fluid Ounce(s) · 59 Milliliter(s) View ingredients & interactions Bixacalm by Bixa Botanical Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Bucked Up Pre-Workout Apple Spice by Bucked Up Powder 10.85 Ounce(s) · 307.5 Gram(s) View ingredients & interactions Carmelite Water Blend by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Carmelite Water Blend 450 mg by TerraVita Premium Collection Capsule 100 Capsule(s) View ingredients & interactions Carmelite Water Blend Chocolate Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Carmelite Water Blend Mint Flavor by TerraVita Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions
Pharmacist Counseling Corner

Nutmeg: Common Questions

What is Nutmeg used for, and does it work?
People use Nutmeg for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Nutmeg interact with prescription medications?
Yes. We list 528 medications with a known interaction with Nutmeg. Use the checker above to see how Nutmeg interacts with a specific drug.
How are Nutmeg interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Nutmeg with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Nutmeg interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Nutmeg commonly used for?
Nutmeg is mainly used as a cooking spice. In traditional medicine it has been used for digestive problems, diarrhea, sleep, and pain, but there is little strong scientific evidence that it treats these conditions.
Can too much Nutmeg be dangerous?
Yes. Taking large amounts (around a couple of teaspoons or more) can cause Nutmeg poisoning, with symptoms like nausea, dizziness, rapid heartbeat, confusion, and hallucinations. Stick to normal cooking amounts.
Is Nutmeg safe during pregnancy?
Normal food amounts are generally considered acceptable, but you should avoid medicinal or large doses during pregnancy because they may be harmful. Talk to your doctor before using Nutmeg as a remedy.
Does Nutmeg help you sleep?
Some people use a small pinch of Nutmeg in warm milk to relax before bed, but this is based on tradition rather than solid scientific proof. Do not use large amounts to try to improve sleep, as they can be toxic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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