Medication interaction hub

What Supplements Interact with Chlorthalidone, Clonidine?

Chlorthalidone, Clonidine brand names: Clorpres, Combipres. Every interaction below applies to the brands too.

224 Interactions 8 Major 192 Moderate 24 Minor
Curated & coded by · Clinical Pharmacist · Updated October 7, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Chlorthalidone, Clonidine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Chlorthalidone, Clonidine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Clorpres pairs chlorthalidone, a diuretic, with clonidine, and both work by lowering blood pressure, so the 224 supplements and herbs on file deserve more than a casual read. Most either push blood pressure lower than intended or, like tyramine, fight the medication and let pressure climb. A second large group compounds the diuretic side, draining potassium or, with calcium-rich products such as dolomite, raising calcium to dangerous levels. Eight interactions carry a major rating, and understanding those comes first.

Activated charcoal is another of the majors; it can soak up either drug in the gut and blunt treatment, so keep it well separated from any dose. About twenty entries raise sun sensitivity instead. Of the rest, 192 rate moderate and 24 minor, nearly all tracing back to blood pressure or potassium in gentler form. Learn the eight majors first; the page below fills in everything else.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 192 Minor 24 No known interaction 1,228

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Chlorthalidone, Clonidine: Top Interactions at a Glance

The most significant Chlorthalidone, Clonidine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 224 interacting ingredients — plus 1,228 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Chlorthalidone, Clonidine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Chlorthalidone, Clonidinei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Tyramine + Chlorthalidone, Clonidinei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Chlorthalidone, Clonidinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Chlorthalidone, Clonidinei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction Major Likelihood Probable Dolomite + Chlorthalidone, Clonidinei

Taking thiazides with dolomite might increase the risk of hypercalcemia and kidney failure.

Read the full interaction Major Likelihood Probable Lithium + Chlorthalidone, Clonidinei

Theoretically, taking lithium supplements with loop diuretics might increase lithium levels and adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Chlorthalidone, Clonidine

All 1,452 ingredients in our database, ranked by severity — 224 with a Chlorthalidone, Clonidine interaction on file and 1,228 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Chlorthalidone, Clonidine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Beet with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Full Beet + Chlorthalidone, Clonidine answer

Can you take Birch with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, birch might interfere with diuretic therapy.

Full Birch + Chlorthalidone, Clonidine answer

Can you take Black Psyllium with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Chlorthalidone, Clonidine answer

Can you take Blond Psyllium with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Chlorthalidone, Clonidine answer

Can you take Carob with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Chlorthalidone, Clonidine answer

Can you take Coenzyme Q10 with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Chlorthalidone, Clonidine answer

Can you take Dendrobium with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. The dendrobium constituent dendrobine is reported to have hypotensive effects.

Full Dendrobium + Chlorthalidone, Clonidine answer

Can you take Fenugreek with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fenugreek may also have an additive effect on blood pressure-lowering medications.

Full Fenugreek + Chlorthalidone, Clonidine answer

Can you take Humann Superbeets Heart Chews with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).

Full Humann Superbeets Heart Chews + Chlorthalidone, Clonidine answer

Can you take Juniper with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.

Full Juniper + Chlorthalidone, Clonidine answer

Can you take Karaya Gum with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Chlorthalidone, Clonidine answer

Can you take Marshmallow with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Chlorthalidone, Clonidine answer

Can you take N-methyltyramine with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In animal research, N-methyltyramine increased blood pressure.

Full N-methyltyramine + Chlorthalidone, Clonidine answer

Can you take Nicotinamide Riboside with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.

Full Nicotinamide Riboside + Chlorthalidone, Clonidine answer

Can you take Pu-erh Tea with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, using pu-erh tea with diuretic drugs might increase the risk of hypokalemia.

Full Pu-erh Tea + Chlorthalidone, Clonidine answer

Can you take Puravive with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin, which has been found to slightly reduce blood pressure in individuals with mild hypertension (https://pubmed.nc...

Full Puravive + Chlorthalidone, Clonidine answer

Can you take Stevia with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.

Full Stevia + Chlorthalidone, Clonidine answer

Can you take Xanthan Gum with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, xanthan gum can alter the absorption of oral drugs due to its fiber qualities.

Full Xanthan Gum + Chlorthalidone, Clonidine answer

Can you take Equol with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, equol might cause additive diuretic effects when used with diuretic drugs.

Full Equol + Chlorthalidone, Clonidine answer

Can you take Hemp with Chlorthalidone, Clonidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.

Full Hemp + Chlorthalidone, Clonidine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Chlorthalidone, Clonidine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Chlorthalidone, Clonidine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Chlorthalidone, Clonidine sits in 7 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Chlorthalidone, Clonidine through this category.

Diuretic Drugs 73 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

73 of the supplement ingredients on this page reach Chlorthalidone, Clonidine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Chlorthalidone, Clonidine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Chlorthalidone, Clonidine through this category.

Thiazide Diuretics 5 ingredients

Medications that increase fluid loss. Supplements affecting fluid or electrolytes (like potassium) can interact with them.

5 of the supplement ingredients on this page reach Chlorthalidone, Clonidine through this category.

Clonidine (Catapres) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Chlorthalidone, Clonidine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Chlorthalidone, Clonidine through this category.

Related: does Chlorthalidone, Clonidine deplete any nutrients?

Chlorthalidone, Clonidine has 18 reported nutrient associations in the research literature — see the Chlorthalidone, Clonidine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Chlorthalidone, Clonidine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Chlorthalidone, Clonidine.

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Products that contain Chlorthalidone, Clonidine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Chlorthalidone, Clonidine.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Chlorthalidone, Clonidine & Supplements: Common Questions

What supplements interact with Chlorthalidone, Clonidine?
Our database currently documents 224 ingredients with a known Chlorthalidone, Clonidine interaction (8 major, 192 moderate, 24 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 224. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Chlorthalidone, Clonidine supplement interactions are the most serious?
The 8 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal, American Mistletoe and Dolomite — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Chlorthalidone, Clonidine?
Plenty of supplements coexist fine with Chlorthalidone, Clonidine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Clorpres have the same supplement interactions as Chlorthalidone, Clonidine?
Yes — Clorpres, Combipres all contain Chlorthalidone, Clonidine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Chlorthalidone, Clonidine deplete any vitamins or nutrients?
It might — Chlorthalidone, Clonidine has 18 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Chlorthalidone, Clonidine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Chlorthalidone, Clonidine and my other medications?
This page covers Chlorthalidone, Clonidine against supplements and herbal ingredients. Checking Chlorthalidone, Clonidine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 7, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.