Medication interaction hub

What Supplements Interact with Ethiny Estradiol, Levonorgestrel?

Ethiny Estradiol, Levonorgestrel brand names: Logynon, Microgynon 30 ED. Every interaction below applies to the brands too.

214 Interactions 3 Major 171 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethiny Estradiol, Levonorgestrel? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethiny Estradiol, Levonorgestrel against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A supplement that lowers hormone levels in a birth control pill can mean an unplanned pregnancy, and St. John's wort can do exactly that to ethinyl estradiol and levonorgestrel (Logynon, Microgynon 30 ED) by speeding up how your liver clears the hormones. It is one of three major-rated interactions on this page, with activated charcoal and grapefruit rounding out the trio, and given what a failed pill means, those three deserve genuine caution and your attention first.

The other 211 entries are milder, 171 moderate and 40 minor, and most trace back to how the pill is processed or absorbed. Bulky fiber products like glucomannan can blunt absorption of oral medicines, so keep them well apart from your dose. And a quirk you may actually feel is caffeine, since these hormones slow its breakdown, meaning coffee, tea, or guarana can leave you wired longer than expected.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 171 Minor 40 No known interaction 1,238

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethiny Estradiol, Levonorgestrel: Top Interactions at a Glance

The Ethiny Estradiol, Levonorgestrel supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 214 interacting ingredients — plus 1,238 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethiny Estradiol, Levonorgestrel Combinations Today

The Ethiny Estradiol, Levonorgestrel + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Likely Grapefruit + Ethiny Estradiol, Levonorgestreli

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Probable Cocoa + Ethiny Estradiol, Levonorgestreli

Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Read the full interaction Moderate Likelihood Possible Androstenedione + Ethiny Estradiol, Levonorgestreli

Theoretically, androstenedione might increase the effects and adverse effects of estrogens.

Read the full interaction Moderate Likelihood Possible Eucalyptus + Ethiny Estradiol, Levonorgestreli

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Brussels Sprout + Ethiny Estradiol, Levonorgestreli

Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ethiny Estradiol, Levonorgestreli

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Ethiny Estradiol, Levonorgestrel

All 1,452 ingredients in our database, ranked by severity — 214 with a Ethiny Estradiol, Levonorgestrel interaction on file and 1,238 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethiny Estradiol, Levonorgestrel?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Ethiny Estradiol, Levonorgestrel?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Ethiny Estradiol, Levonorgestrel answer

Can you take Cocoa with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might increase the levels and adverse effects of caffeine.

Full Cocoa + Ethiny Estradiol, Levonorgestrel answer

Can you take Androstenedione with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, androstenedione might increase the effects and adverse effects of estrogens.

Full Androstenedione + Ethiny Estradiol, Levonorgestrel answer

Can you take Eucalyptus with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.

Full Eucalyptus + Ethiny Estradiol, Levonorgestrel answer

Can you take Brussels Sprout with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Full Brussels Sprout + Ethiny Estradiol, Levonorgestrel answer

Can you take German Chamomile with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.

Full German Chamomile + Ethiny Estradiol, Levonorgestrel answer

Can you take Ginger with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Ethiny Estradiol, Levonorgestrel answer

Can you take Ginkgo with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.

Full Ginkgo + Ethiny Estradiol, Levonorgestrel answer

Can you take Goji with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP3A4 and reduce metabolism of CYP3A4 substrates.

Full Goji + Ethiny Estradiol, Levonorgestrel answer

Can you take Goldthread with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Ethiny Estradiol, Levonorgestrel answer

Can you take Grape with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Full Grape + Ethiny Estradiol, Levonorgestrel answer

Can you take Guar Gum with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Ethiny Estradiol, Levonorgestrel answer

Can you take Gum Arabic with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Ethiny Estradiol, Levonorgestrel answer

Can you take Gymnema with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Full Gymnema + Ethiny Estradiol, Levonorgestrel answer

Can you take Hemp with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Ethiny Estradiol, Levonorgestrel answer

Can you take Hesperidin with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Ethiny Estradiol, Levonorgestrel answer

Can you take Higenamine with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Ethiny Estradiol, Levonorgestrel answer

Can you take Hops with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen rec...

Full Hops + Ethiny Estradiol, Levonorgestrel answer

Can you take Horny Goat Weed with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.

Full Horny Goat Weed + Ethiny Estradiol, Levonorgestrel answer

Can you take Hu Zhang with Ethiny Estradiol, Levonorgestrel?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.

Full Hu Zhang + Ethiny Estradiol, Levonorgestrel answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethiny Estradiol, Levonorgestrel is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethiny Estradiol, Levonorgestrel, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethiny Estradiol, Levonorgestrel sits in 10 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ethiny Estradiol, Levonorgestrel through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ethiny Estradiol, Levonorgestrel through this category.

Related: does Ethiny Estradiol, Levonorgestrel deplete any nutrients?

Ethiny Estradiol, Levonorgestrel has 14 reported nutrient associations in the research literature — see the Ethiny Estradiol, Levonorgestrel nutrient depletion report.

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Take a Supplement Product? Check the Whole Bottle Against Ethiny Estradiol, Levonorgestrel

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethiny Estradiol, Levonorgestrel.

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Pharmacist Counseling Corner

Ethiny Estradiol, Levonorgestrel & Supplements: Common Questions

What supplements interact with Ethiny Estradiol, Levonorgestrel?
In our interaction database, 214 supplement and herbal ingredients have an interaction with Ethiny Estradiol, Levonorgestrel on file — 3 rated major, 171 moderate, and 40 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Ethiny Estradiol, Levonorgestrel supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ethiny Estradiol, Levonorgestrel?
That depends entirely on which supplement. The honest answer for Ethiny Estradiol, Levonorgestrel is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Logynon have the same supplement interactions as Ethiny Estradiol, Levonorgestrel?
Yes — Logynon, Microgynon 30 ED all contain Ethiny Estradiol, Levonorgestrel, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethiny Estradiol, Levonorgestrel deplete any vitamins or nutrients?
It might — Ethiny Estradiol, Levonorgestrel has 14 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethiny Estradiol, Levonorgestrel nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethiny Estradiol, Levonorgestrel and my other medications?
This page covers Ethiny Estradiol, Levonorgestrel against supplements and herbal ingredients. Checking Ethiny Estradiol, Levonorgestrel against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.