Medication interaction hub

What Supplements Interact with Levofloxacin (ophthalmic)?

Levofloxacin (ophthalmic) brand name: Levofloxacin. Every interaction below applies to the brands too.

64 Interactions 3 Major 49 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Levofloxacin (ophthalmic)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Levofloxacin (ophthalmic) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

64 supplements and herbal ingredients have interactions with Levofloxacin (ophthalmic) on file in the HelloPharmacist interaction database — 3 rated major, 49 moderate, and 12 minor. The most serious involve Apple, Grapefruit and Sweet Orange.

Our assessment: with 3 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Levofloxacin (ophthalmic).

Major 3 Moderate 49 Minor 12 No known interaction 1,388

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Levofloxacin (ophthalmic): Top Interactions at a Glance

The most significant Levofloxacin (ophthalmic) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 64 interacting ingredients — plus 1,388 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Levofloxacin (ophthalmic) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Apple + Levofloxacin (ophthalmic)i

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.

Read the full interaction Major Likelihood Likely Grapefruit + Levofloxacin (ophthalmic)i

Grapefruit juice can decrease levels of drugs that are substrates of OATP.

Read the full interaction Major Likelihood Likely Sweet Orange + Levofloxacin (ophthalmic)i

Consuming sweet orange juice can decrease oral absorption of OATP substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Levofloxacin (ophthalmic)

All 1,452 ingredients in our database, ranked by severity — 64 with a Levofloxacin (ophthalmic) interaction on file and 1,388 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Levofloxacin (ophthalmic)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Dolomite with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the magnesium in dolomite might decrease the absorption of quinolone antibiotics.

Full Dolomite + Levofloxacin (ophthalmic) answer

Can you take Fermented Milk with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotic drugs might decrease the effectiveness of fermented milk.

Full Fermented Milk + Levofloxacin (ophthalmic) answer

Can you take Green Tea with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, green tea might reduce the absorption of organic anion-transporting polypeptide (OATP) substrates.

Full Green Tea + Levofloxacin (ophthalmic) answer

Can you take Iron with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron might decrease levels of quinolone antibiotics by reducing their absorption.

Full Iron + Levofloxacin (ophthalmic) answer

Can you take Lacticaseibacillus Casei with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus casei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Casei + Levofloxacin (ophthalmic) answer

Can you take Lacticaseibacillus Paracasei with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus paracasei with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Paracasei + Levofloxacin (ophthalmic) answer

Can you take Lacticaseibacillus Rhamnosus with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L.

Full Lacticaseibacillus Rhamnosus + Levofloxacin (ophthalmic) answer

Can you take Lactiplantibacillus Pentosus with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Pentosus + Levofloxacin (ophthalmic) answer

Can you take Lactiplantibacillus Plantarum with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactiplantibacillus plantarum with antibiotic drugs might decrease the effectiveness of L.

Full Lactiplantibacillus Plantarum + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Acidophilus with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Crispatus with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Crispatus + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Delbrueckii with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Delbrueckii + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Gasseri with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Gasseri + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Helveticus with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Helveticus + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Jensenii with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Jensenii + Levofloxacin (ophthalmic) answer

Can you take Lactobacillus Johnsonii with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus johnsonii with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Johnsonii + Levofloxacin (ophthalmic) answer

Can you take Latilactobacillus Sakei with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Full Latilactobacillus Sakei + Levofloxacin (ophthalmic) answer

Can you take Levilactobacillus Brevis with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Levilactobacillus brevis with antibiotic drugs might decrease the effectiveness of L.

Full Levilactobacillus Brevis + Levofloxacin (ophthalmic) answer

Can you take Ligilactobacillus Salivarius with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Ligilactobacillus salivarius with antibiotic drugs might decrease the effectiveness of L.

Full Ligilactobacillus Salivarius + Levofloxacin (ophthalmic) answer

Can you take Limosilactobacillus Fermentum with Levofloxacin (ophthalmic)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Limosilactobacillus fermentum with antibiotic drugs might decrease the effectiveness of L.

Full Limosilactobacillus Fermentum + Levofloxacin (ophthalmic) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Levofloxacin (ophthalmic) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Levofloxacin (ophthalmic), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Levofloxacin (ophthalmic) sits in 3 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Levofloxacin (ophthalmic) through this category.

Quinolone Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Levofloxacin (ophthalmic) through this category.

Organic Anion-Transporting Polypeptide Substrates (Oatp) 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Levofloxacin (ophthalmic) through this category.

About Levofloxacin (ophthalmic)

Levofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, kidney, prostate, and skin infections.

Generic name: Levofloxacin (ophthalmic)  ·  Brand name: Levofloxacin.

See the full Levofloxacin drug information

Related: does Levofloxacin (ophthalmic) deplete any nutrients?

Levofloxacin (ophthalmic) has 11 reported nutrient associations in the research literature — see the Levofloxacin (ophthalmic) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Levofloxacin (ophthalmic)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Levofloxacin (ophthalmic).

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Pharmacist Counseling Corner

Levofloxacin (ophthalmic) & Supplements: Common Questions

What supplements interact with Levofloxacin (ophthalmic)?
More than you might expect — 64 in total, though they are far from equal: 3 are rated major, 49 moderate, and 12 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Apple, Grapefruit, Sweet Orange.
Which Levofloxacin (ophthalmic) supplement interactions are the most serious?
The 3 major-rated combinations — led by Apple, Grapefruit and Sweet Orange — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Levofloxacin (ophthalmic)?
Usually yes — most people on Levofloxacin (ophthalmic) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Levofloxacin have the same supplement interactions as Levofloxacin (ophthalmic)?
Yes — Levofloxacin all contain Levofloxacin (ophthalmic), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Levofloxacin (ophthalmic) deplete any vitamins or nutrients?
It might — Levofloxacin (ophthalmic) has 11 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Levofloxacin (ophthalmic) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Levofloxacin (ophthalmic) and my other medications?
This page covers Levofloxacin (ophthalmic) against supplements and herbal ingredients. Checking Levofloxacin (ophthalmic) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Levofloxacin drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.