Medication interaction hub

What Supplements Interact with Nafcillin?

Nafcillin brand name: Nallpen. Every interaction below applies to the brands too.

58 Interactions 2 Major 54 Moderate 2 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Nafcillin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Nafcillin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Anyone on nafcillin (Nallpen) is usually fighting a serious staph infection, and that makes this a time to be genuinely careful with supplements. Of the 58 with a known interaction on file, the two rated major, Siberian cocklebur and asarabacca, both stress the kidneys and could compound damage while you are being treated. Nearly half the rest are probiotics, 27 in all, which an antibiotic this strong can simply kill off before they do you any good.

Another 19 rev up the liver enzymes that clear many drugs, which can shift medication levels, and six can make seizures easier to trigger. Fifty-four of the 58 rate moderate and two minor, so most entries mean blunted benefit rather than harm, but the kidney herbs deserve the closest look. Flag any herbal product to your pharmacist, and space probiotics well apart from each dose so they survive long enough to do their job.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 54 Minor 2 No known interaction 1,394

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Nafcillin: Top Interactions at a Glance

The most significant Nafcillin supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 58 interacting ingredients — plus 1,394 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Nafcillin + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Nafcillini

Siberian cocklebur can adversely affect the kidney.

Read the full interaction Major Likelihood Possible Asarabacca + Nafcillini

Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Read the full interaction
The complete list

Every Supplement Checked Against Nafcillin

All 1,452 ingredients in our database, ranked by severity — 58 with a Nafcillin interaction on file and 1,394 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Nafcillin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Alpine Ragwort with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in alpine ragwor...

Full Alpine Ragwort + Nafcillin answer

Can you take Asian Water Plantain with Nafcillin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Studies on animals have shown that Asian water plantain extract, which contains triterpenoids, is generally safe at doses up to 1440 mg/kg o...

Full Asian Water Plantain + Nafcillin answer

Can you take Ginkgo with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Nafcillin answer

Can you take Cannabidiol (cbd) with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might decrease cannabidiol levels.

Full Cannabidiol (cbd) + Nafcillin answer

Can you take Cannabis with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might reduce the levels and clinical effects of cannabis.

Full Cannabis + Nafcillin answer

Can you take Coltsfoot with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Coltsfoot + Nafcillin answer

Can you take Comfrey with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid constituents in comfrey.

Full Comfrey + Nafcillin answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might reduce the levels and clinical effects of THC.

Full Delta-9-tetrahydrocannabinol (thc) + Nafcillin answer

Can you take Dendrobium with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Nafcillin answer

Can you take Dusty Miller with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in dusty miller.

Full Dusty Miller + Nafcillin answer

Can you take Evodia with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers might decrease the levels and clinical effects of evodia.

Full Evodia + Nafcillin answer

Can you take Flaxseed with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Nafcillin answer

Can you take Golden Ragwort with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers might increase the risk of adverse effects from the pyrrolizidine alkaloid (PA) constituents in golden ragwor...

Full Golden Ragwort + Nafcillin answer

Can you take Gravel Root with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4).

Full Gravel Root + Nafcillin answer

Can you take Groundsel with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking CYP3A4 inducers with groundsel might increase the risk of pyrrolizidine alkaloid toxicity, such as hepatotoxicity.

Full Groundsel + Nafcillin answer

Can you take Hemp Agrimony with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA) which are substrates of cytochrome P450 3A4 (CYP3A4).

Full Hemp Agrimony + Nafcillin answer

Can you take Hound's Tongue with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inducers can increase the toxicity of the pyrrolizidine alkaloid (PA) constituents of hound's tongue.

Full Hound's Tongue + Nafcillin answer

Can you take Melatonin with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Nafcillin answer

Can you take Mountain Ash with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Nafcillin answer

Can you take Ostarine with Nafcillin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.

Full Ostarine + Nafcillin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Nafcillin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Nafcillin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Nafcillin sits in 4 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Nafcillin through this category.

Cytochrome P450 3A4 (Cyp3A4) Inducers 19 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

19 of the supplement ingredients on this page reach Nafcillin through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Nafcillin through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Nafcillin through this category.

About Nafcillin

Nafcillin Injection is a penicillin-type antibiotic used to treat serious bacterial infections caused by penicillinase-producing staphylococci (staph bacteria that resist standard penicillin).

Generic name: Nafcillin  ·  Brand name: Nallpen.

See the full Nafcillin Injection drug information

Related: does Nafcillin deplete any nutrients?

Nafcillin has 7 reported nutrient associations in the research literature — see the Nafcillin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Nafcillin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Nafcillin.

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Pharmacist Counseling Corner

Nafcillin & Supplements: Common Questions

What supplements interact with Nafcillin?
More than you might expect — 58 in total, though they are far from equal: 2 are rated major, 54 moderate, and 2 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Asarabacca, Bacillus Coagulans.
Which Nafcillin supplement interactions are the most serious?
The 2 major-rated combinations — led by Siberian Cocklebur and Asarabacca — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Nafcillin?
Usually yes — most people on Nafcillin can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Nallpen have the same supplement interactions as Nafcillin?
Yes — Nallpen all contain Nafcillin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Nafcillin deplete any vitamins or nutrients?
It might — Nafcillin has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Nafcillin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Nafcillin and my other medications?
This page covers Nafcillin against supplements and herbal ingredients. Checking Nafcillin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Nafcillin Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.