Drug & supplement interaction

Chanca Piedra + Nafcillin

Nafcillin brand name: Nallpen.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chanca Piedra and Nafcillin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Chanca Piedra and Nafcillin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Nafcillin and Chanca Piedra in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chanca Piedra safety at a glance

Chanca Piedra overall Use caution Often well tolerated short-term, but high-quality safety data are limited.
Pregnancy Possibly Unsafe When used during pregnancy or in those trying to become pregnant. Animal research shows that chanca piedra, particularly at high doses, may have contraceptive e... Read the full pregnancy detail
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Nafcillin and Chanca Piedra? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Nafcillin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Nafcillin is filed under 4 classifications — including cytochrome p450 3a4 (cyp3a4) inducers, antibiotic drugs, nephrotoxic drugs. Chanca Piedra has documented interactions with 8 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Nafcillin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chanca Piedra Does Interact With Other Medications

Chanca Piedra has 871 moderate, 149 minor known drug interactions in our database — Nafcillin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 871 Minor 149 No known interaction 1,810 (incl. Nafcillin)
Taking anything else?

Check Another of Your Medications Against Chanca Piedra

Covers the 2,830 medications we’ve checked against Chanca Piedra. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chanca Piedra and Nafcillin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach pain / Vomiting / Nausea Additional detail

    Chanca Piedra

    “Orally, use of chanca piedra can cause abdominal pain, nausea, and vomiting.”

    Chanca Piedra · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    2 sources cited
    1. 99849. Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
    2. 107946. Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed

    Nafcillin

    Listed in the ADVERSE REACTIONS section of the FDA label for Nafcillin. Read the label on DailyMed ›

  • Tiredness Additional detail

    Chanca Piedra

    “Orally, chanca piedra was associated with cases of fatigue in one clinical trial.”

    Chanca Piedra · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 107946. Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed

    Nafcillin

    Listed in the ADVERSE REACTIONS section of the FDA label for Nafcillin. Read the label on DailyMed ›

Effects for Nafcillin come from the ADVERSE REACTIONS section of its FDA label; effects for Chanca Piedra come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 918 voluntary FDA FAERS reports for Nafcillin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chanca Piedra in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used during pregnancy or in those trying to become pregnant. Animal research shows that chanca piedra, particularly at high doses, may have contraceptive effects or may increase the risk of low birth weight or birth defects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Nafcillin

This page covers Chanca Piedra only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Nafcillin page lists 58 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Siberian Cocklebur (major), Alkanna (moderate), Alpine Ragwort (moderate) and Aristolochia (moderate).

By severity: 2 major · 54 moderate · 2 minor.

From our pharmacist’s overview on the Nafcillin page

“Anyone on nafcillin (Nallpen) is usually fighting a serious staph infection, and that makes this a time to be genuinely careful with supplements. Of the 58 with a known interaction on file, the two rated major, Siberian cocklebur and asarabacca, both stress the kidneys and could compound damage while you are being treated.”

Reviewed by 2 · Jul 18, 2026

Open the Nafcillin interaction page

One more smart check

Taking Chanca Piedra as Part of a Dietary Supplement Product? Check It for Interactions

We hold 355 real supplement products containing Chanca Piedra, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chanca Piedra. Even though Chanca Piedra itself has no known interaction with Nafcillin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chanca Piedra and Nafcillin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chanca Piedra
Top half

#386 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Nafcillin
Steady interest

#2,646 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chanca Piedra reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chanca Piedra and Nafcillin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chanca Piedra

What is Chanca Piedra?

Chanca Piedra
  • Kidney stones
  • Gallstones
  • Liver support
  • Urinary tract health
  • Digestive complaints

Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly small or preliminary, so it should not replace proven treatments. Talk with your pharmacist or doctor before using it, especially if you have a medical condition or take medications.

Phyllanthus niruri · Phyllanthaceae · Whole plant, leaves, and stems · Tea, capsules, tablets, liquid extracts, tinctures, dried powder

An interaction check asks whether these two react with each other — it does not ask whether Chanca Piedra is a good idea for someone in your situation. Here is what our Chanca Piedra record says about it on its own.

Chanca Piedra: dosing

There is no official or well-established standardized dose for Chanca piedra. Studies have used different forms and amounts, so it is hard to recommend one specific dose.The safest approach is to follow the directions on the product label and not exceed them.

From our Chanca Piedra monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chanca Piedra monograph & all interactions
Medication

About Nafcillin Injection

What Is Nafcillin Injection Used For?

Brand name: Nallpen

NAFCILLIN Injection is used to treat infections caused by staphylococci — specifically strains that produce an enzyme called penicillinase, which makes them resistant to regular penicillin. Susceptibility testing is performed to confirm the bacteria will respond to nafcillin before or shortly after starting treatment.

Nafcillin may also be started right away when a resistant staph infection is strongly suspected, even before test results are available. It should not be used for infections caused by bacteria that would respond to standard penicillin G, or for infections caused by non-staph organisms.

Most-Reported Side Effects for Nafcillin

From FAERS, the FDA’s public side-effect reporting system (918 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Renal failure acute 64 reports
Rash 56 reports
Acute kidney injury 49 reports
Fever 44 reports
Tubulointerstitial nephritis 43 reports
See full Nafcillin Injection drug information
Keep checking

Other Drugs & Chanca Piedra

Browse every other medication we’ve checked against Chanca Piedra — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
871Moderate
149Minor
1,809No known interaction
871 Moderate 149 Minor 1,809 No interaction
Moderate

871 interactions

Showing 60 of 871 moderate interactions — see all 871 on the Chanca Piedra page.

Minor

149 interactions

Showing 60 of 149 minor interactions — see all 149 on the Chanca Piedra page.

No interaction 1,809 drugs checked — show the list

We also checked Chanca Piedra against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,809 medications checked with no known interaction — see the full Chanca Piedra list.

See the full Chanca Piedra interactions page
See every supplement checked against Nafcillin, ranked by severity
Evidence & sources

Chanca Piedra References

The 18 references that drive our Chanca Piedra monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
  3. Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
  4. Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
  5. Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
  6. Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
  7. Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
  8. Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
  9. Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
  10. Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
  11. Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
  12. Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
  13. Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
  14. Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
  15. Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chanca Piedra and Nafcillin Together: Common Questions

Is it safe to take Chanca Piedra with Nafcillin?
We do not list a known interaction between Chanca Piedra and Nafcillin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chanca Piedra and Nafcillin have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Chanca Piedra and Nafcillin combination checked?
Interactions in our licensed database are recorded against drug classes. Nafcillin is filed under 4 classifications, and Chanca Piedra has documented interactions with 8 drug classes — none of Nafcillin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chanca Piedra interact with any other medications?
Yes. Chanca Piedra has 1,020 documented drug interactions in our database — Nafcillin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Nafcillin interact with any supplements?
Yes. Nafcillin has documented interactions with 58 supplements in our database — Chanca Piedra is not one of them. The Nafcillin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chanca Piedra monograph Uses, safety profile, and every drug interaction in one place Nafcillin Injection drug information The full plain-English guide to this medication Nafcillin supplement interactions Every supplement checked against Nafcillin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Nafcillin and Chanca Piedra?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.