Medication interaction hub

What Supplements Interact with Ropinirole?

Ropinirole brand names: Requip, Adartrel. Every interaction below applies to the brands too.

101 Interactions 1 Major 67 Moderate 33 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ropinirole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ropinirole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Activated charcoal deserves the closest look on this page. It is the only one of the 101 entries rated major against ropinirole (Requip, Adartrel), because charcoal can bind the drug in the gut and shrink the amount that actually reaches you, and for someone relying on ropinirole for Parkinson's disease or restless legs, that can mean symptoms creeping back. This is a list to treat with real care, and that single major risk is the place to start.

Most of the remaining entries, 67 rated moderate and 33 minor, involve a liver enzyme called CYP1A2 that clears ropinirole from the body. Ingredients like CBD and melatonin may slow that enzyme and push ropinirole levels higher, side effects along with them, while others, including broccoli eaten in large daily amounts, can speed it up and weaken the dose. A few herbs also act on dopamine directly, stacking onto what the medication already does.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 67 Minor 33 No known interaction 1,351

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ropinirole: Top Interactions at a Glance

The Ropinirole supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 101 interacting ingredients — plus 1,351 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ropinirole Combinations Today

The Ropinirole + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Grapefruit + Ropinirolei

Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Possible Black Pepper + Ropinirolei

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Possible Yohimbe + Ropinirolei

Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Ceylon Leadwort + Ropinirolei

Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ropinirolei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Moderate Likelihood Probable Cannabidiol (cbd) + Ropinirolei

Cannabidiol may increase levels of drugs metabolized by CYP1A2.

Read the full interaction
The complete list

Every Supplement Checked Against Ropinirole

All 1,452 ingredients in our database, ranked by severity — 101 with a Ropinirole interaction on file and 1,351 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ropinirole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grapefruit with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grapefruit juice might increase levels of drugs metabolized by CYP1A2.

Full Grapefruit + Ropinirole answer

Can you take Black Pepper with Ropinirole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.

Full Black Pepper + Ropinirole answer

Can you take Yohimbe with Ropinirole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Yohimbe + Ropinirole answer

Can you take Ceylon Leadwort with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 1A2 (CYP1A2) in vitro.

Full Ceylon Leadwort + Ropinirole answer

Can you take Resveratrol with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.

Full Resveratrol + Ropinirole answer

Can you take Rooibos with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Ropinirole answer

Can you take Schizonepeta with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Ropinirole answer

Can you take Slippery Elm with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Ropinirole answer

Can you take St. John's Wort with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. St.

Full St. John's Wort + Ropinirole answer

Can you take Sulforaphane with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sulforaphane might alter the levels and clinical effects of CYP1A2 substrates.

Full Sulforaphane + Ropinirole answer

Can you take Syrian Rue with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the adverse effects of dopamine agonists.

Full Syrian Rue + Ropinirole answer

Can you take Thunder God Vine with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.

Full Thunder God Vine + Ropinirole answer

Can you take Tinospora Cordifolia with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP1A2.

Full Tinospora Cordifolia + Ropinirole answer

Can you take Tragacanth with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Ropinirole answer

Can you take Vitex Agnus-castus with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitex agnus-castus could interfere with dopamine agonists.

Full Vitex Agnus-castus + Ropinirole answer

Can you take Wheatgrass with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Ropinirole answer

Can you take Zizyphus with Ropinirole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Ropinirole answer

Can you take Thyroid Extract with Ropinirole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Ropinirole answer

Can you take Agar with Ropinirole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Ropinirole answer

Can you take Algin with Ropinirole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Ropinirole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ropinirole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ropinirole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ropinirole sits in 5 interaction categories. Open any one to see what the group means:

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ropinirole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ropinirole through this category.

Dopamine Agonists 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Ropinirole through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ropinirole through this category.

Ropinirole (Requip) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ropinirole through this category.

About Ropinirole

Ropinirole is a dopamine agonist used to treat Parkinson's disease and moderate-to-severe primary Restless Legs Syndrome (RLS).

Generic name: Ropinirole  ·  Brand names: Requip, Adartrel.

See the full Ropinirole drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ropinirole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ropinirole.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Ropinirole-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Ropinirole.

Osteoherbal by Health Concerns contains Evodia Warm Cycle Teapills by Plum Flower contains Evodia Sugar Coated Gan Mao Ling by Plum Flower contains Evodia Mu Xiang Shun Qi Teapills by Plum Flower contains Evodia
Pharmacist Counseling Corner

Ropinirole & Supplements: Common Questions

What supplements interact with Ropinirole?
Our database currently documents 101 ingredients with a known Ropinirole interaction (1 major, 67 moderate, 33 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 101. The highest-ranked right now: Activated Charcoal, Cannabidiol (cbd), Coffee Charcoal.
Which Ropinirole supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ropinirole?
Plenty of supplements coexist fine with Ropinirole; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Requip have the same supplement interactions as Ropinirole?
Yes — Requip, Adartrel all contain Ropinirole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ropinirole and my other medications?
This page covers Ropinirole against supplements and herbal ingredients. Checking Ropinirole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ropinirole drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.