Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Extra FlexiJoint IFR Formula Ingredients & Drug Interactions

by CATALO

Extra FlexiJoint IFR Formula label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra FlexiJoint IFR Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Extra FlexiJoint IFR Formula is a dietary supplement by CATALO with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,570 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Joint Support IFR Formula, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Extra FlexiJoint IFR Formula by CATALO

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra FlexiJoint IFR Formula by CATALO — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Extra FlexiJoint IFR Formula by CATALO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 4 active ingredients.
  • “Joint Support IFR Formula” is a proprietary blend — the label gives one combined amount (790 mg) without saying how much of each component you get.

Extra FlexiJoint IFR Formula contains 4 active ingredients. Sodium is included as a mineral component.

Meriva Turmeric Phytosome is a formulation of turmeric designed for absorption. ApresFlex and Casperome Boswellia Phytosome are two standardized extracts of boswellia, also called frankincense resin, chosen for joint support.

The product also contains inactive ingredients (rice concentrate, plant polysaccharides, and magnesium stearate) that serve as fillers and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support healthy joint pain and inflammatory response.
  • We looked for evidence on: Ankylosing spondylitis, Carpal tunnel syndrome, Exercise-induced muscle damage, Exercise-induced muscle soreness, Fibromyalgia, Gout — and 4 related terms.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Turmeric is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Knee pain.

For turmeric, the data shows possibly effective evidence for depression, high cholesterol (hyperlipidemia), hay fever (allergic rhinitis), and indigestion (dyspepsia). For boswellia (the active ingredient in both ApresFlex and Casperome), the data shows possibly effective evidence for osteoarthritis.

Sodium's effectiveness is rated likely effective for cystic fibrosis and possibly effective for kidney damage from the antibiotic amphotericin B, though these uses fall outside typical joint support. The joint support blend itself (Joint Support IFR Formula) lacks established effectiveness ratings in our data.

The evidence, ingredient by ingredient Sodium Cannabis Turmeric Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Turmeric is generally well tolerated in food amounts and as a supplement in the short term, though concentrated doses may cause constipation, diarrhea, nausea, heartburn, or—rarely—liver damage with prolonged use (70+ reported cases, most resolved after stopping). Boswellia is generally well tolerated orally in the short term; common side effects include abdominal pain, diarrhea, headache, and nausea.

Sodium is essential in small amounts but excess intake is linked to high blood pressure and heart strain; normal dietary amounts are fine, but avoid sodium supplements or very high intake without medical advice. Regarding pregnancy, turmeric is likely safe during pregnancy and lactation, while boswellia lacks enough safety data—it is best avoided during pregnancy and breastfeeding.

Sodium in pregnancy is rated both likely safe and possibly unsafe in our data, so speak with your doctor or pharmacist about your individual pregnancy plans.

Side effects, ingredient by ingredient Sodium Cannabis Turmeric Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Boswellia Serrata, Turmeric, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications; lithium.
  • For scale: 1,401 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use blood pressure medicines (antihypertensives), lithium, cancer or chemotherapy drugs, immunosuppressants, corticosteroids, tramadol, sulfasalazine, methotrexate, tamoxifen, or any drug broken down by liver enzymes including CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2 substrates. Discuss your full medication list with your doctor or pharmacist to confirm it's safe to combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Extra FlexiJoint IFR Formula combines three substances with joint and inflammation benefits (turmeric and boswellia are possibly effective for osteoarthritis) but carries moderate medication interactions across a very large number of prescriptions. If you take blood pressure medicines, lithium, cancer drugs, immunosuppressants, or drugs broken down by your liver, you'll need to check your exact medications with your doctor or pharmacist before starting.

Women who are pregnant or breastfeeding should discuss this product with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra FlexiJoint IFR Formula, straight from the product label.

Brand CATALO
Net contents 60 Vegetarian Capsule(s); 37.9 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303063
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra FlexiJoint IFR Formula by CATALO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Sugar0 Gram(s)--
Sodium1 mg--
Carbohydrates0.6 Gram(s)--
Energy4 Kcal--
Total Fat0.2 Gram(s)--
Saturated Fat0.1 Gram(s)--
Trans Fat0 Gram(s)--
Protein0 Gram(s)--
Joint Support IFR Formula790 mg--
Meriva Turmeric Phytosome0 NP--
ApresFlex0 NP--
Casperome Boswellia Phytosome0 NP--

Other ingredients: Rice Concentrate, Plant Polysaccharides, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Support healthy inflammatory response Clinically Proven Effective Sourced from Nature

Main functions: Speedy relieve joint pain Promote joint comfort and mobility and reduce stiffness Target mediators of neck and shoulder, back, wrists, elbows, knees, ankles etc. to alleviate joint discomforts

This product is made from natural sources and may have color variation. This is a normal phenomenon and does not affect product quality. Made in USA

FDA Statement of Identity

Dietary Supplement

Formula

CATALO Extra FlexiJoint IFR Formula contains Meriva Curcumin-Phosphatidylcholine Complex, with Phytosome a patented technology to achieve higher bioavailability and 29-fold higher absorption rate. It is clinically proven to effectively relieve joint pain and promote mobility. AspresFlex and Casperome Boswellia Serrata Gum Resin Extract are specially added to provide synergistic effect on targeting mediators of comfort and flexibility, which is clinically proven to be effective as fast as within 5-7days. CATALO Extra FlexiJoint IFR Formula provides an excellent soothing effect on joint pain, stiffness and mobility, with natural premium ingredients. 1 Belcaro, G., ct al. (2010). Altern Med Rev, 15(4), 337-44 (Refer to Meriva Turmeric Phytosome) 2 Cuoma J., et al. (2006) J Nat Prod. 74,664-669 3 Vishal A.A., Mishra A & Raychaudhuri S.P. (2001) Int. J. Med. Sci. 8(7), 615-622

Suitable for: Severely degenerated joints, frequent recurrence of inflexible joints and joint pain, injured joint, joint stiffness and strain, discomfort during weather change

Phytosome More Bioavailable Meriva

Brand IP Statement(s)

Phytosome More Bioavailable is a trademark of Indena S.p.A. Patent No.: US 4,963,527; US 6,297,218 Meriva and Casperome are trademarks of Indena S.p.A AspresFlex is a registered trademark of PL Thomas - Laila Nutra LLC FlexiJoint is a trademark of CATALO Group

General Statements

Scan and Discover More About This Product!

Suggested/Recommended/Usage/Directions

Serving directions For adult, for normal usage, take 2 capsules daily after meal. For intense use, take 2 capsules twice daily after meal. Take with 250ml of water.

Storage

Storage Keep in a dry and cool place. Avoid direct sunlight.

Seals/Symbols

Certified Good Manufacturing Practices cGMP

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra FlexiJoint IFR Formula by CATALO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra FlexiJoint IFR Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra FlexiJoint IFR Formula by CATALO

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
1 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Carbohydrates

0.6 Gram(s) per serving
  • › Sugar

Energy

4 Kcal per serving

Protein

0 Gram(s) per serving

Joint Support IFR Formula

Interacts with
1,136 drugs
790 mg per serving

Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not). Some uses, such as chemotherapy-related nausea,...

Joint Support IFR Formula monograph & interactions

Other (inactive) ingredients: Rice Concentrate, Plant Polysaccharides, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra FlexiJoint IFR Formula by CATALO Drug Interactions

Want to check YOUR meds against Extra FlexiJoint IFR Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,570Drugs
2 Major 1,544 Moderate 24 Minor

Ingredients driving the most interactions

Joint Support IFR Formula 1,136
Sodium 205

Individual Drug Interactions

The ingredients in Extra FlexiJoint IFR Formula interact with 1,570 drugs. Click any drug to see the details.

2 of the 5 ingredients in Extra FlexiJoint IFR Formula interact with drugs. Each result below shows which ingredient is responsible. Joint Support IFR Formula Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra FlexiJoint IFR Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Joint Support IFR Formula18 drug types · 1,136 drugs

Warfarin (Coumadin)

Concomitant use with cannabis seems to increase the levels and clinical effects of warfarin.
In vitro research shows that the cannabis constituents delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol inhibit the cytochrome P450 2C9 (CYP2C9)-mediated 7-hydroxylation of S-warfarin in a concentration-dependent manner.
Additionally, there are multiple case reports of patients chronically taking warfarin that developed a spike in international normalized ratio (INR) after using cannabis in various forms, including smoking cannabis, taking medical cannabis orally, or drinking water infused with cannabis flower. One patient smoked 2-2.5 grams in one week and another patient had doubled the amount of THC consumed from 7.5 mg to 14.7 mg daily for one week.

Likelihood Probable Evidence D
Alcohol (Ethanol)

Theoretically, cannabis might have additive effects when used with alcohol.
Cannabis can have CNS depressant effects, similar to synthetic delta-9-tetrahydrocannabinol (THC). Theoretically, concomitant use of alcohol with cannabis can have additive effects including psychomotor impairment, sedation, and changes in mood and behavior.

Likelihood Possible Evidence D
Anesthesia

Cannabis use might alter the safety and clinical effects of various forms of anesthesia.
A small clinical study shows that higher doses of propofol may be needed to achieve relaxation and loss of consciousness in chronic cannabis users compared with nonusers. Another small clinical study shows that use of cannabis within 72 hours prior to undergoing surgery requiring atropine anesthesia may increase the risk of sustained postoperative tachycardia. The exact mechanisms of these interactions are unclear. Obtain a patient's history of cannabis use preoperatively and advise patients to discontinue cannabis use for at least 2 weeks prior to undergoing surgery.

Likelihood Possible Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, cannabis might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research shows that the cannabis constituents delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) inhibit platelet aggregation.

Likelihood Possible Evidence D
Barbiturates

Theoretically, cannabis might increase the levels and adverse effects of barbiturates.
Some research shows that synthetic delta-9-tetrahydrocannabinol (THC) increases the elimination half-life of pentobarbital by 4 hours when dosed concomitantly.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, cannabis might have additive effects if used with other CNS depressants.
Cannabis can have CNS depressant effects. Combining cannabis with other CNS depressants might result in additive or synergistic effects. A small clinical trial in healthy adults shows that inhaling a high-grade cannabis (Bedrocan International B.V., Veendam, The Netherlands) 100 mg, containing delta-9-tetrahydrocannabinol 21.8% and cannabinol 0.1%, modestly increases subjective feelings of sedation when compared with cannabis alone.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Cannabis may increase levels of drugs metabolized by CYP2C19.
Research shows that cannabidiol (CBD), a constituent of cannabis, inhibits CYP2C19. In clinical studies and case reports, cannabidiol use resulted in significant increases in the serum levels of topiramate, methadone, citalopram, omeprazole, and N-desmethylclobazam, the primary active metabolite of clobazam. These chemicals are metabolized by CYP2C19. Concomitant use of cannabis with CYP2C19 substrates may increase the risk for adverse effects from these substrates.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inducers

Theoretically, drugs that are CYP2C9 inducers might decrease the effects of cannabis.
Delta-9-tetrahydrocannabinol (THC), an active constituent of cannabis, is a substrate of CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Inhibitors

Theoretically, drugs that are CYP2C9 inhibitors might increase the adverse effects of cannabis.
Delta-9-tetrahydrocannabinol (THC), an active constituent of cannabis, is a substrate of CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, cannabis might increase the levels and adverse effects of CYP2C9 substrates.
In vitro research shows that the cannabis constituents delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol moderately inhibit the CYP2C9-mediated 7-hydroxylation of S-warfarin in a concentration-dependent manner. In vitro research also shows that cannabis extracts modestly inhibit the CYP2C9 metabolism of tolbutamide; extracts providing the specific cannabinoids CBD and cannabigerol (CBG) had stronger inhibitory effects than extracts containing THC and CBD.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, cannabis might decrease the levels and clinical effects of CYP2E1 substrates.
In vitro research shows that cannabis can induce the activity of CYP2E1, which might increase the metabolism of CYP2E1 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might reduce the levels and clinical effects of cannabis.
Delta-9-tetrahydrocannabinol (THC), an active constituent of cannabis, is a substrate of CYP3A4 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inhibitors

Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of cannabis.
Delta-9-tetrahydrocannabinol (THC), an active constituent of cannabis, is a substrate of CYP3A4 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cannabis may increase the levels and adverse effects of CYP3A4 substrates.
In vitro research shows that cannabis can inhibit the activity of CYP3A4 enzymes, which might decrease the metabolism of CYP3A4 substrates. In vitro research also shows that cannabis extracts modestly inhibit the CYP3A4 metabolism of testosterone; extracts providing the specific cannabinoids CBD and cannabigerol (CBG) had stronger inhibitory effects than extracts containing THC and CBD.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, cannabis might alter levels of drugs that are substrates of P-glycoprotein (P-gp).
Most in vitro research suggests that constituents of cannabis, including cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), can inhibit P-gp and increase the accumulation of probe compounds by reducing P-gp mediated drug efflux. In vitro studies in kidney cell lines show that a 1-hour exposure to CBD and THC inhibits P-gp. Cannabis may also alter the expression of P-gp, although this effect appears to vary based on duration of exposure. Some in vitro research in lymphoblastoid leukemia cell lines indicates that a 1-hour exposure to cannabinoids does not affect P-gp expression, while a prolonged 72-hour exposure decreases P-gp expression. Other in vitro research in these cell lines shows that a 4-hour exposure to THC and CBD induces P-gp gene expression, while exposure for longer than 4 hours and up to 48 hours does not induce P-gp gene expression.

Likelihood Possible Evidence D
Theophylline

Smoking cannabis while taking theophylline might reduce the levels and clinical effects of theophylline.
Similar to smoking tobacco, smoking cannabis seems to increase the metabolism of theophylline.

Likelihood Possible Evidence D
Thrombolytic Drugs

Cannabis might augment the effects of thrombolytic drugs and increase the risk of severe bleeding.
A case of cerebral hemorrhage has been reported for a 51-year-old female and chronic cannabis user who had consumed a large amount of cannabis prior to receiving recombinant tissue plasminogen activator (rtPA) for ischemic stroke. Hemorrhage had been ruled out prior to providing the rtPA. The exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Antipsychotic Drugs

Cannabis does not seem to affect blood levels or effects of some antipsychotic drugs.
Human research shows that cannabis use does not affect blood levels or clinical effects of amisulpride, aripiprazole, or olanzapine in patients with schizophrenia and related disorders.

Likelihood Unlikely Evidence B
Joint Support IFR Formula full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra FlexiJoint IFR Formula, from the product label.

CATALO

See all CATALO products
Name
CATALO Natural Health Foods
Street Address
5/F, Suite C-D, 15 Cheung Shun St.
City
Hong Kong
Phone Number
(852) 3556 8686
Web Address
CATALO.com
Pharmacist Counseling Corner

Extra FlexiJoint IFR Formula by CATALO: Common Questions

Does Extra FlexiJoint IFR Formula by CATALO interact with any medications?
Yes. Based on its ingredients, Extra FlexiJoint IFR Formula has a known interaction with 1,570 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra FlexiJoint IFR Formula contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for joint pain?
Turmeric and boswellia are both rated possibly effective for osteoarthritis. The turmeric here is formulated as Meriva, a phytosome meant to improve absorption. Results vary by person and dose, so discuss realistic expectations with your doctor.
Can I take this if I'm pregnant or breastfeeding?
Turmeric is likely safe in pregnancy and during breastfeeding. Boswellia lacks enough safety data—our facts advise against it during pregnancy and breastfeeding. Because this formula contains boswellia, talk with your doctor or pharmacist about whether it's right for you.
What side effects might I experience?
Common side effects from turmeric include constipation, diarrhea, nausea, and heartburn. Boswellia may cause abdominal pain, diarrhea, headache, nausea, and heartburn. Sodium in excess can contribute to high blood pressure. Most people tolerate these ingredients without serious issues, but stop and contact your doctor if you develop severe symptoms or signs of liver problems.
Is there sodium added to this product, and should I worry about my salt intake?
Yes, sodium is one of the 4 active ingredients. If you have high blood pressure, heart disease, or kidney disease, or if you take blood pressure medicines, lithium, or corticosteroids, excess sodium from supplements can be a concern. Keep your total sodium intake at or below 2,300 mg daily and discuss this product with your doctor.
What is Meriva Turmeric Phytosome?
Meriva is a patented formulation that binds turmeric's active compound (curcumin) to a plant-based carrier (phytosome) to improve absorption in your digestive system. It's designed to deliver turmeric more effectively than plain turmeric powder.
What are ApresFlex and Casperome Boswellia Phytosome?
Both are standardized extracts of boswellia serrata resin (frankincense) formulated as phytosomes for better absorption. They're included for their possibly effective action on osteoarthritis. ApresFlex and Casperome are branded versions designed for consistency across batches.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra FlexiJoint IFR Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra FlexiJoint IFR Formula label
Go deeper

The Full Monographs Behind Extra FlexiJoint IFR Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Cannabis

Interacts with 1,136 drugs

Cannabis contains many active compounds, mainly THC (which causes a 'high') and CBD (which does not). Some uses, such as chemotherapy-related nausea, certain seizure disorders, and muscle sp...

Read the full Cannabis monograph → Herb & supplement monograph

Turmeric

Interacts with 1,133 drugs

Turmeric is a popular spice whose main active compounds, curcuminoids, are studied mostly for inflammation and joint pain. Some research is promising, but quality is mixed and curcumin is po...

Read the full Turmeric monograph → Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

Extra FlexiJoint IFR Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 417 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
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See these in context on the Sodium monograph →

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See these in context on the Cannabis monograph →

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See these in context on the Turmeric monograph →

Boswellia Serrata 16 references
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See these in context on the Boswellia Serrata monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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