Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

HMS Hemp Extract Ingredients & Drug Interactions

by HMS Nutrition

HMS Hemp Extract label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HMS Hemp Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HMS Hemp Extract is a dietary supplement by HMS Nutrition with 2 active ingredients. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HMS Hemp Extract by HMS Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with HMS Hemp Extract by HMS Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of HMS Hemp Extract by HMS Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

HMS Hemp Extract contains 2 active ingredients: hemp oil and methylsulfonylmethane (MSM). Hemp oil is extracted from hemp seed and is thought to contribute estrogenic and blood pressure-modulating compounds.

MSM is an organic sulfur compound, though we hold no monograph data on its specific roles. The capsules themselves are made from vegetable cellulose and cellulose — the inactive ingredients that hold and deliver the actives.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp product and its label doesn't state a use — see Hemp's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for hemp oil's effectiveness is limited. For constipation, atopic dermatitis (eczema), and familial hypercholesterolemia (a genetic cholesterol condition), the data shows insufficient reliable evidence to rate whether it works.

That doesn't mean it's ineffective — it means the research isn't yet strong enough to say one way or the other.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods and oils are generally well tolerated in normal dietary amounts. However, concentrated hemp extracts and supplements like this one are less well studied, so caution is advised.

In larger supplement doses, side effects are uncommon, but rare cases of allergic reactions — including anaphylaxis, hives, facial swelling, and breathing problems — have been reported. There's also a rare case report of elevated liver enzymes and hepatitis in a young child given very high doses of hemp extract for seizures.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use estrogens (including birth control or hormone therapy) — hemp oil may theoretically interfere with their effects. Also double-check blood pressure medications, including ACE inhibitors, blood thinners or antiplatelet drugs, and any medications that rely on liver enzymes CYP1A2 or CYP3A4 to be broken down.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in hemp oil's potential effects on skin or digestion, but the evidence for these uses isn't well established yet. If you take estrogen-based hormones, blood pressure medications, blood thinners, or any drug metabolized by your liver, you'll want to check your specific medications with your doctor or pharmacist first.

A rare hemp allergy is possible — if you've never had hemp before, be aware of that risk.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HMS Hemp Extract, straight from the product label.

Brand HMS Nutrition
Barcode (UPC) 046708996245
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229891
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HMS Hemp Extract by HMS Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
046708996245
IngredientAmount% DV
Methylsulfonylmethane400 mg--
Hemp Oil50 mg--

Other ingredients: Vegetable Cellulose Capsule, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take one (1) capsule daily with water, or as directed by a healthcare professional.

Precautions

Caution: Do not exceed recommended dose.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or who are taking prescription medication should consult a physician before taking this or any dietary supplement.

Pregnant and nursing mothers, children under the age of 18, and individuals with a known medical condition or who are taking prescription medication should consult a physician before taking this or any dietary supplement.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in the USA Manufactured in an FDA inspected facility Good manufacturing practices Sourced from a GMP certified facility

Formulation

THC free

Formula

6000 mg

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HMS Hemp Extract by HMS Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HMS Hemp Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HMS Hemp Extract by HMS Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Methylsulfonylmethane

400 mg per serving

Hemp Oil

Interacts with
938 drugs
50 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp Oil monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

HMS Hemp Extract by HMS Nutrition Drug Interactions

Want to check YOUR meds against HMS Hemp Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

Hemp Oil 938

Individual Drug Interactions

The ingredients in HMS Hemp Extract interact with 938 drugs. Click any drug to see the details.

1 of the 2 ingredients in HMS Hemp Extract interact with drugs. Each result below shows which ingredient is responsible. Hemp Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in HMS Hemp Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Oil6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HMS Hemp Extract, from the product label.

HMS Nutrition

See all HMS Nutrition products
Name
HMS Nutrition LLC
Street Address
501 Silverside Rd, Suite 341
City
Wilmington
State
DE
ZipCode
19809
Pharmacist Counseling Corner

HMS Hemp Extract by HMS Nutrition: Common Questions

Does HMS Hemp Extract by HMS Nutrition interact with any medications?
Yes. Based on its ingredients, HMS Hemp Extract has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HMS Hemp Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my birth control pill?
Not without checking first. Hemp oil has estrogenic effects that theoretically could interfere with how hormonal birth control works. Talk with your doctor or pharmacist about whether this product is safe alongside your specific birth control.
I have a tree nut allergy — is hemp seed safe for me?
Hemp seed allergy is uncommon but documented, and it's separate from tree nut allergies. Still, if you've never had hemp before and you have multiple food allergies, mention it to your doctor or pharmacist first.
Does this actually work for skin conditions like eczema?
The evidence we have is insufficient to say whether it does. There's not enough reliable research yet to know if hemp oil helps with atopic dermatitis or other skin conditions.
I take a blood pressure medication — is this okay to combine?
Hemp oil may theoretically add to the effects of blood pressure drugs, which could lower your blood pressure too much. Check with your doctor or pharmacist before starting this product if you're on any blood pressure medication.
Can I take this while I'm pregnant or breastfeeding?
The product facts don't include safety data for pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether it's right for you during this time.
What is methylsulfonylmethane (MSM)?
MSM is an organic sulfur compound, but we don't have detailed data on its specific roles or effects in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HMS Hemp Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HMS Hemp Extract label
Go deeper

The Full Monographs Behind HMS Hemp Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

HMS Hemp Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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