Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

LuraLean Caps Ingredients & Drug Interactions

by Life Extension

LuraLean Caps label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LuraLean Caps against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LuraLean Caps is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for weight loss and appetite control, constipation, high cholesterol.Based on those ingredients, 2,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against LuraLean Caps by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with LuraLean Caps by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of LuraLean Caps by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

LuraLean Caps contains one active ingredient: glucomannan, a soluble fiber extracted from konjac plant root. It works by absorbing water in your digestive tract, adding bulk and viscosity to help move things along and support healthy cholesterol and blood sugar levels.

The capsule also holds inactive ingredients—microcrystalline cellulose, vegetable cellulose, and stearic acid—which are common binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight loss and appetite control.
  • We looked for evidence on: Obesity, Metabolic syndrome, Hyperlipidemia, weight management, satiety.
  • The strongest evidence on file: Glucomannan is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Glucomannan is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

Glucomannan has been studied for constipation, diabetes, and high cholesterol (hyperlipidemia), and the evidence rates it as possibly effective for all three. There isn't enough reliable evidence yet to say whether it helps with high blood pressure.

Real results vary from person to person, so you may want to give it a few weeks and see how you respond.

The evidence, ingredient by ingredient Glucomannan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glucomannan is generally well tolerated when you drink plenty of water with it—that's key. The most common side effects are mild digestive ones: bloating, gas, abdominal discomfort, diarrhea, or nausea, especially if you take more than 3 grams daily.

Serious but rare risks include choking or blockage in your throat or digestive tract if you swallow it dry or without enough liquid. During pregnancy, there isn't enough safety data to know whether it's okay; talk with your doctor before using it.

Safety during breastfeeding is also unclear, so caution is advised—check with your doctor or pharmacist.

Side effects, ingredient by ingredient Glucomannan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glucomannan.
  • The most serious interaction on file is rated Moderate.
  • For scale: 2,023 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start LuraLean Caps, check with your doctor or pharmacist about any oral medications you take. Glucomannan may reduce how well your body absorbs drugs taken by mouth—a Moderate concern.

Spacing doses a few hours apart may help, but your healthcare provider is the best person to confirm the timing for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

LuraLean Caps may help with constipation, blood sugar control, or cholesterol if you're looking for a fiber option. The main thing to watch is its potential to interfere with oral medications, so space doses a few hours apart and clear it with your own doctor or pharmacist before starting, especially if you take diabetes drugs, heart medications, or anything else by mouth.

Always take it with plenty of water to avoid choking or blockage.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LuraLean Caps, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870147015
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 62810
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LuraLean Caps by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Vegetarian Capsule(s)
Maximum serving Sizes:
4 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
737870147015
IngredientAmount% DV
LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract2000 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Results may vary.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take four (4) capsules twice daily with 8 to 16 ounces of liquid 30 minutes before the heaviest meals, or as recommended by a healthcare practitioner.

This supplement should be taken in conjunction with a healthy diet and regular exercise program.

Precautions

Caution: Take at least two hours apart from medications. Because this product may lower blood glucose, consult your healthcare provider before taking this product if you are taking blood glucose lowering medication.

Taking fiber products without adequate liquid may increase the risk of choking. Consult your healthcare provider before taking this product if you have difficulty swallowing or esophageal narrowing.

Warnings: - Keep out of reach of children.

- Do not exceed recommended dose. - Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Brand IP Statement(s)

LuraLean is a registered trademark of AHD International LLC.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store tightly closed in a cool, dry place.

General

Q01470C

Formula

Special Propolmannan Particle Size

Advanced Fiber for appetite control

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LuraLean Caps by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LuraLean Caps label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LuraLean Caps by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract

Interacts with
2,022 drugs
2000 mg per serving Form: Amorphophallus konjac, ssp. Amorphophallus japonica

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and mo...

LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

LuraLean Caps by Life Extension Drug Interactions

Want to check YOUR meds against LuraLean Caps?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,022Drugs
2,022 Moderate

Ingredients driving the most interactions

LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract 2,022

Individual Drug Interactions

The ingredients in LuraLean Caps interact with 2,022 drugs. Click any drug to see the details.

1 of the 1 ingredient in LuraLean Caps interact with drugs. Each result below shows which ingredient is responsible. LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract

Each ingredient & the kinds of drugs it affects

For each ingredient in LuraLean Caps with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract1 drug type · 2,022 drugs

Oral Drugs

Theoretically, glucomannan may decrease absorption of drugs taken orally.
Due to its viscosity and bulking effects, there is concern that glucomannan can decrease the absorption of oral drugs. A small clinical study in healthy volunteers shows that taking glyburide 2.5 mg plus glucomannan 3.9 grams with breakfast reduces plasma levels of glyburide when compared with breakfast and glyburide alone. In addition, animal research demonstrates this effect on amoxicillin, but shows increased absorption of metronidazole. This mouse model also demonstrates that metronidazole elimination is prolonged, but amoxicillin elimination is enhanced by 38%; glucomannan may also affect the distribution of some drugs. To avoid changes in absorption, take glucomannan 30-60 minutes after taking oral drugs.

Likelihood Probable Evidence B
LuraLean Propolmannan (Amorphophallus konjac K. Koch, ssp. Amorphophallus japonica) fiber extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LuraLean Caps, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

LuraLean Caps by Life Extension: Common Questions

Does LuraLean Caps by Life Extension interact with any medications?
Yes. Based on its ingredients, LuraLean Caps has a known interaction with 2,022 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LuraLean Caps contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take LuraLean Caps with my other medications?
Glucomannan can interfere with how your body absorbs oral drugs. Try to take this product at least 2 hours away from your other medications, but definitely talk to your doctor or pharmacist first—they can help you figure out the safest schedule for your specific prescriptions.
What are the most common side effects?
Most people experience mild digestive issues like bloating, gas, constipation, diarrhea, or nausea—especially if you take more than 3 grams daily. The key is drinking plenty of water with it. Serious side effects like choking or blockage are rare but can happen if you swallow it dry.
Does glucomannan actually work for constipation and cholesterol?
The evidence shows it's possibly effective for constipation, blood sugar control, and high cholesterol. Results vary from person to person, so you may need to use it for a few weeks to see whether it helps you.
Is it safe to take during pregnancy or breastfeeding?
There isn't enough reliable data to say it's safe during pregnancy—talk with your doctor first. Safety while breastfeeding is also unclear, so caution is advised. Check with your doctor or pharmacist for personalized guidance.
What exactly is glucomannan?
It's a soluble fiber extracted from konjac plant root. It absorbs water in your digestive system, adding bulk and thickness to help move things along and support healthy cholesterol and blood sugar levels.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if LuraLean Caps is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LuraLean Caps label
Go deeper

The Full Monographs Behind LuraLean Caps’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glucomannan

Interacts with 2,022 drugs

Glucomannan is a soluble fiber from the konjac root that swells into a gel in your stomach, which may help with mild weight loss, constipation, and modestly lowering cholesterol. It is gener...

Read the full Glucomannan monograph →
Sources

Sources & How We Checked

LuraLean Caps's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glucomannan 15 references
  1. Henry DA, Mitchell AS, Aylward J, et al. Glucomannan and risk of oesophageal obstruction. Br Med J 1986;292:591-2. PubMed
  2. Shima K, Tanaka A, Ikegami H, et al. Effect of dietary fiber, glucomannan, on absorption of sulfonylurea in man. Horm Metab Res 1983;15:1-3. PubMed
  3. Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. PubMed
  4. Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. PubMed
  5. Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber
  6. Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. PubMed
  7. Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. PubMed
  8. Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100.
  9. Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. PubMed
  10. Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev
  11. Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. PubMed
  12. Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7.
  13. Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-
  14. Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864.
  15. Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. PubMed

See these in context on the Glucomannan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team