Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

SST Ingredients & Drug Interactions

by Performix

SST label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SST against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

SST is a dietary supplement by Performix with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 1,721 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Niacin, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SST by Performix

Ask about any prescription or over-the-counter medication and we check it for interactions with SST by Performix — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SST by Performix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 13 active ingredients.
  • “Diffusion Carrier Oil” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “TERRA Pod Ballistic Beadlet” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Performix Suspension Super Thermo Complex” is a proprietary blend — the label gives one combined amount (1,170 mg) without saying how much of each component you get.

SST contains 13 active and inactive ingredients. The active ones are caffeine anhydrous (a stimulant), niacin (a B vitamin), vitamin B12 (essential for nerve and blood-cell function), yohimbe bark extract (which contains yohimbine, an alpha-adrenergic stimulant), theacrine (a stimulant related to caffeine), bioperine or black pepper extract (which contains piperine, a bioavailability enhancer), cayenne pepper powder (containing capsaicin, used for pain and metabolism), huperzine A (a cholinesterase inhibitor linked to cognitive effects), mucuna pruriens extract (containing levodopa, a dopamine precursor), safflower oil extract, ashwagandha (Sensoril brand, used for stress and sleep), and ginger CO2 supercritical extract (used for inflammation and nausea).

Medium chain triglycerides (a type of fat) and several proprietary blends round out the formula. The inactive ingredients are standard capsule and tablet excipients—gelatin, starches, colorants, silicates, and similar fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: energy, focus and fat metabolism.
  • We looked for evidence on: Attention, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Cognitive impairment, Age-related cognitive decline, Thermogenesis — and 2 related terms.
  • The closest evidence on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Cognitive impairment.
  • Also on file: Caffeine is rated "Possibly Ineffective" for Attention deficit-hyperactivity disorder (ADHD).

The evidence is mixed across ingredients and uses. Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance.

Niacin is likely effective for pellagra and possibly effective for HIV-related cholesterol problems and metabolic syndrome. Vitamin B12 is effective for its own deficiency and imerslund-Grasbeck disease, and likely effective for cyanide poisoning.

Cayenne pepper is likely effective for nerve pain after shingles (postherpetic neuralgia) and diabetic nerve damage. Ginger is possibly effective for pregnancy-related nausea and vomiting, menstrual pain, and osteoarthritis.

Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder. The rest—yohimbe, theacrine, huperzine A, bioperine, safflower, and mucuna pruriens—have insufficient or no reliable evidence for the conditions they're marketed to address in this product.

This is a stimulant-heavy formula; if you're taking it for mental alertness or athletic performance, the evidence supports caffeine and theacrine, but the combination with yohimbe and mucuna pruriens (dopaminergic agents) raises safety concerns we'll address below.

The evidence, ingredient by ingredient Niacin Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 11 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 11 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate amounts is generally well tolerated, but high doses can cause anxiety, insomnia, tremors, headaches, and rarely, stroke. Niacin commonly causes flushing and gastrointestinal upset, and at high doses can damage the liver—especially sustained-release forms.

Vitamin B12 is very safe with no upper limit. Yohimbe is a significant safety concern: it causes anxiety, agitation, hypertension, rapid heart rate, and tremors, and its potency is unpredictable because it's a plant extract.

Theacrine's long-term safety isn't established. Huperzine A is a potent cholinesterase inhibitor that causes dose-dependent cholinergic side effects (blurred vision, diarrhea, nausea, sweating) and can lower heart rate.

Mucuna pruriens causes diarrhea, flatulence, nausea, headache, and insomnia. Ashwagandha is generally well tolerated short-term but has rare case reports of liver failure and hepatitis.

Ginger is safe in typical amounts but can cause heartburn, diarrhea, and abdominal discomfort. Regarding pregnancy and breastfeeding: caffeine is possibly unsafe in pregnancy at high doses—ask your doctor about safe limits; niacin in high doses should be avoided; vitamin B12 is needed and safe; yohimbe is unsafe in pregnancy; theacrine should be avoided; huperzine A should be avoided; mucuna pruriens should be avoided because its levodopa can lower prolactin and reduce milk supply; ashwagandha is likely unsafe in pregnancy; and ginger is likely safe but check with your doctor.

Safflower flower may stimulate the uterus and is best avoided in medicinal amounts during pregnancy.

Side effects, ingredient by ingredient Niacin Vitamin B12

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 12 of the 12 matched ingredients can interact with medications — Safflower, Yohimbe, Huperzine A, Black Pepper, Niacin, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,722 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against these drug types before you take SST. Most critical: do not combine with ephedrine (Major severity).

Avoid MAOIs (antidepressants) due to yohimbe and mucuna pruriens. Be cautious with methyldopa, levodopa itself, or non-selective MAOIs in combination with mucuna pruriens.

For Moderate-severity interactions, double-check if you take seizure medications (phenobarbital, carbamazepine, phenytoin), blood pressure drugs (antihypertensives), blood thinners (warfarin, anticoagulants, antiplatelets), sedatives (pentobarbital, benzodiazepines), diabetes medications, antipsychotics, statins, heart medications (propranolol, nifedipine, losartan), liver-toxic drugs, or certain antibiotics (quinolones, ciprofloxacin). If you take any of these, run SST through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

SST is a potent multi-ingredient stimulant and cognitive formula with significant medication interactions you must check before starting—especially if you take blood pressure, seizure, psychiatric, or heart medications, or MAOIs. The combination of caffeine, yohimbe, theacrine, and mucuna pruriens makes this a powerful sympathomimetic and dopaminergic product; it's not for people with hypertension, heart conditions, or anxiety disorders.

Talk to your pharmacist or doctor before you take this, particularly if you're pregnant, breastfeeding, or on any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SST, straight from the product label.

Brand Performix
Net contents 60 Liquid Capsule(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 268674
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SST by Performix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Total Fat1 Gram(s)1%
Medium Chain Triglycerides0 NP--
Caffeine Anhydrous250 mg--
Niacin12 mg75%
Vitamin B121000 mcg41667%
Calories10 Calorie(s)--
Yohimbe bark extract0 NP--
Theacrine0 NP--
Bioperine0 NP--
Cayenne Pepper powder0 NP--
Huperzine A0 NP--
Diffusion Carrier Oil0 NP--
TERRA Pod Ballistic Beadlet0 NP--
Mucuna pruriens extract0 NP--
Safflower Oil Extract0 NP--
Performix Suspension Super Thermo Complex1170 mg--
Sensoril0 NP--
Ginger CO2 Supercritical Extract0 NP--

Other ingredients: Gelatin, Sucrose, Starch, Talc, Pharmaceutical Glaze, Polyvinylpolypyrrolidone, FD&C Blue 1, FD&C Red 40, FD&C Yellow 5, Calcium Silicate, Maltodextrin, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Terra Intelligent dosing Performix SST is an innovative, multi-phase release thermogenic, delivering unrelenting energy, sharp mental focus and enhanced fat metabolism. Using TERRA Intelligent Dosing technology, an innovative Multi-Coating Matrix, SST delivers premium ingredients via multiple targeted phases to help offer an optimized release profile along with improved delivery.

Key ingredients in this formula help promote thermogenesis, boost energy levels and stimulate calorie burning. This product is to be used in conjunction with a calorie-reduced diet and regular exercise program. The degree of improvement varies by individual and is related to your diet, exercise, daily activities, age and body frame.

Ballistic body energy Fat metabolism Enhanced mental focus

Formula

Ballistic Body Energy Don't count your workouts. Make your workouts count. The Super Strength Thermo Complex in Performix SST features TERRA Pod Ballistic Beadlets that are packed with powerful ingredients including Caffeine, TeaCrine, and Yohimbine to stimulate thermogenesis, creating and supporting energy for the entire body. Fat Metabolism Performix SST promotes increased resting metabolic rate, thermogenesis and energy expenditure for ultimate fat burning and lean muscle development. This formula also provides Medium Chain Triglycerides for a fat-derived energy source, primed for absorption. Enhanced Mental Focus Performix SST doesn't just help you crush your physical goals, it also supports your mental drive throughout the day. Caffeine, Ashwagandha and Huperzine A work together to promote positive mood, alertness and mental focus. Powered by: Sensoril Vitalizing mind & body TeaCrine BioPerine

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

High performance people deserve high performing products. Performix is here to inspire and fuel you. Fuel up with SST Energy products and get inspired at www.PerformixDriven.com SST wasn't created for those with a 9-5. It's for those with a 24/7.

Please recycle

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 serving (2 capsules) in the morning on an empty stomach. To assess your tolerance, start with 1/2 serving (1 capsule) and work up to the full dose. Do not exceed one (1) serving per day. This product should not be taken in combination with other products containing caffeine or other stimulants. Do not take within six hours of bedtime. Please read the entire label before use.

Precautions

Warning: Do not use if pregnant, nursing, or plan on becoming pregnant.

This product is intended for use by healthy adults over the age of 18 and should be avoided by those sensitive to caffeine or other ingredients that have known stimulant effects. Contains caffeine. Do not combine with alcohol. Not intended for use by those with a medical condition. Use only as directed. Do not exceed recommended daily intake. Do not consume caffeine from other sources including, but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine.

Do not consume caffeine from other sources including, but not limited to, coffee, tea, soda and other dietary supplements or medications containing phenylephrine or caffeine. Consult a physician or licensed qualified health care professional prior to use if you are taking medication including, but not limited to MAO inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, psedoephedrine, or other stimulants, or if you have a medical condition including, but not limited to, heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, enlarged prostate or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache or shortness of breath. Do not use if safety seal under cap is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

TeaCrine is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc. BioPerine is a patented product and a registered trademark of Sabinsa Corporation U.S #5,536,506. Sensoril is protected under U.S. Patent 6,713,092 and is a registered trademark of Natreon, Inc.

Seals/Symbols

Made in the USA Proudly made in the USA with carefully selected ingredients of international and domestic origin. cGMP Good Manufacturing Practice Quality Product

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SST by Performix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SST label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SST by Performix

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niacin

Interacts with
727 drugs
12 mg per serving Form: Nicotinic Acid

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Performix Suspension Super Thermo Complex

1170 mg per serving
  • › Diffusion Carrier Oil
  • › TERRA Pod Ballistic Beadlet

Other (inactive) ingredients: Gelatin, Sucrose, Starch, Talc, Pharmaceutical Glaze, Polyvinylpolypyrrolidone, FD&C Blue 1, FD&C Red 40, FD&C Yellow 5, Calcium Silicate, Maltodextrin, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

SST by Performix Drug Interactions

Want to check YOUR meds against SST?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,721Drugs
25 Major 1,661 Moderate 35 Minor

Ingredients driving the most interactions

Niacin 727
Vitamin B12 20

Individual Drug Interactions

The ingredients in SST interact with 1,721 drugs. Click any drug to see the details.

2 of the 4 ingredients in SST interact with drugs. Each result below shows which ingredient is responsible. Niacin Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in SST with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Niacin full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SST, from the product label.

Performix

See all Performix products
Name
Performix LLC
Street Address
2255 Sheridan Blvd., Unit C-#108
City
Edgewater
State
CO
ZipCode
80214
Web Address
www.PerformixDriven.com
Pharmacist Counseling Corner

SST by Performix: Common Questions

Does SST by Performix interact with any medications?
Yes. Based on its ingredients, SST has a known interaction with 1,721 medications, including 25 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SST contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is caffeine safe during pregnancy?
Caffeine is rated possibly unsafe in pregnancy at high doses. The facts advise limiting your intake and asking your doctor about safe limits before taking this product. Do not self-dose.
Can I take this if I'm on an antidepressant?
It depends on which one. Yohimbe and mucuna pruriens in this formula carry Major interactions with MAOIs—a serious risk. Even if you're on a different type, check your exact medication with the interaction tool on this page, because several antidepressant classes interact with caffeine and ashwagandha.
Does this product have caffeine?
Yes—it contains caffeine anhydrous plus theacrine, another stimulant. If you're sensitive to caffeine or take medications that interact with it, this product is not for you.
What is yohimbe in here for?
Yohimbe is included as a stimulant to boost energy and alertness. However, it's a potent plant extract with unpredictable strength and a high side-effect profile—anxiety, agitation, high blood pressure, and rapid heartbeat are common. It also carries serious interactions with blood pressure medications and certain antidepressants.
Can I take this while breastfeeding?
No. Mucuna pruriens contains levodopa, which lowers prolactin and can reduce milk supply. Caffeine and theacrine pass into breast milk in small amounts—amounts usually acceptable, but combined with the other actives here, it's not advisable. Check with your doctor or pharmacist first.
Is this safe for someone with high blood pressure?
No. The formula contains multiple stimulants (caffeine, theacrine, yohimbe) that can raise blood pressure, plus ashwagandha and cayenne, both of which may affect blood pressure. If you have hypertension or take blood pressure medication, this product is not appropriate for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SST label
Go deeper

The Full Monographs Behind SST’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

SST's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 652 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
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Ginger 64 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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