Diindolylmethane - Chlorthalidone Interaction
Herbal: Diindolylmethane
Also Known As: DIM
Drug: Chlorthalidone
Brand names:
Hygroton, Thalitone
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 20, 2025
Interaction Details
Chlorthalidone is classified as belonging to the following category: Diuretic Drugs
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
Diindolylmethane Overview
Diindolylmethane (DIM) is a compound found in cruciferous vegetables such as broccoli, cabbage, and kale. It is formed during the digestion of indole-3-carbinol, another compound found in these vegetables. DIM has been studied for its potential health benefits, including improved hormone balance and reduced risk of certain cancers. DIM (Diindolylmethane) supplements are often marketed as a natural way to support hormone balance, specifically estrogen imbalances, and as a 'detoxifying agent'. Supplements with DIM are often paired with Bioperine to improve absorption.
Chlorthalidone Overview
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Chlorthalidone, a 'water pill,' is used to treat high blood pressure and fluid retention caused by various conditions, including heart disease. It causes the kidneys to get rid of unneeded water and salt from the body into the urine.
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This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Diindolylmethane - More Interactions
Diindolylmethane interacts with 268 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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