Clarithromycin

197 interactions 14 explained in plain English
Also sold as: Biaxin
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lovastatin Dihydroergotamine Nasal Spray Alfuzosin Lurasidone Colchicine Ivabradine
12 Contraindicated 168 Major 16 Moderate 1 Minor
All (197) Contraindicated (12) Major (168) Moderate (16) Minor (1)

Contraindicated

Clarithromycin Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity Details Clarithromycin Simvastatin Flolipid Explained An increased risk of myopathy or rhabdomyolysis Details Clarithromycin Alfuzosin UroXatral Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Clarithromycin Dihydroergotamine Injection DHE-45® Injection Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Clarithromycin Dihydroergotamine Nasal Spray Migranal Increased dihydroergotamine exposure and an increased risk of acute ergot toxicity (ergotism) Details Clarithromycin Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Clarithromycin Ivabradine Corlanor Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Clarithromycin Ketoconazole Topical Extina® Foam Increased clarithromycin exposure, an increased ketoconazole exposure and an increased risk of QT interval prolongation Details Clarithromycin Lovastatin Altocor® An increased lovastatin exposure and an increased risk of myopathy or rhabdomyolysis Details Clarithromycin Lurasidone Latuda Increased lurasidone exposure Details Clarithromycin Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Clarithromycin Nimodipine Nimotop Increased nimodipine exposure and risk of significant hypotension Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.