Clarithromycin

197 interactions 14 explained in plain English
Also sold as: Biaxin
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lovastatin Dihydroergotamine Nasal Spray Alfuzosin Lurasidone Colchicine Ivabradine
12 Contraindicated 168 Major 16 Moderate 1 Minor
All (197) Contraindicated (12) Major (168) Moderate (16) Minor (1)

Moderate

Clarithromycin Abemaciclib Verzenio Explained Increased abemaciclib plasma concentration Details Clarithromycin Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding Details Clarithromycin Glimepiride Amaryl Increased risk of hypoglycemia Details Clarithromycin Glipizide Glucotrol An increased risk of hypoglycemia Details Clarithromycin Guanfacine Intuniv Increased guanfacine exposure Details Clarithromycin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Clarithromycin Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Clarithromycin Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Clarithromycin Linezolid Injection Zyvox Increased linezolid exposure Details Clarithromycin Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details Clarithromycin Mometasone Asmanex Increased mometasone plasma concentrations Details Clarithromycin Mometasone Nasal Spray Nasonex Increased mometasone plasma concentrations Details Clarithromycin Mometasone Oral Inhalation Asmanex Increased mometasone plasma concentrations Details Clarithromycin Mometasone Topical Elocon® Increased mometasone plasma concentrations Details Clarithromycin Nateglinide Starlix® Increased nateglinide exposure and an increased risk of hypoglycemia Details Clarithromycin Paricalcitol Zemplar Increased plasma concentrations of paricalcitol Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.