Hydrocodone
56 interactions 6 explained in plain English
Also sold as:
Hysingla
Zohydro
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Cetirizine Injection
Glycopyrronium Topical
Metoclopramide Injection
Nafcillin Injection
Palonosetron Injection
Hydromorphone Injection
Major
Hydrocodone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydrocodone Abametapir Explained Increased exposure of CYP3A4 substrate Details Hydrocodone Amitriptyline Elavil Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of serotonin syndr... Details Hydrocodone Sertraline Explained An increased risk of serotonin syndrome Details Hydrocodone Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Hydrocodone Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Hydrocodone Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Hydrocodone Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Hydrocodone Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Hydrocodone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Hydrocodone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Hydrocodone Clopidogrel Plavix Reduced efficacy of clopidogrel Details Hydrocodone Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Cyclosporine Injection Atopica Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Hydrocodone Cyclosporine Ophthalmic Cequa Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Hydrocodone Dexamethasone Injection Decadron Reduced HYDROcodone exposure and reduced efficacy HYDROcodone Details Hydrocodone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced HYDROcodone exposure and reduced efficacy HYDROcodone Details Hydrocodone Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Hydrocodone Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Hydrocodone Diphenhydramine Injection Banophen Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of respiratory dep... Details Hydrocodone Diphenhydramine Topical Afterbite with Antihistamine Increased risk of urinary retention and/or severe constipation leading to paralytic ileus and an increased risk of respiratory dep... Details Hydrocodone Dolasetron Anzemet An increased risk of serotonin syndrome Details Hydrocodone Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Hydrocodone Esketamine Nasal Spray Spravato Increased risk of sedation Details Hydrocodone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydrocodone Furosemide Injection Disal Reduced efficacy of diuretics Details Hydrocodone Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Hydrocodone Granisetron Injection Granisol An increased risk of serotonin syndrome Details Hydrocodone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydrocodone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Hydrocodone Hydroxychloroquine Plaquenil An increased risk of seizures Details Hydrocodone Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hydrocodone Ketoconazole Topical Extina® Foam Increased HYDROcodone exposure and risk of increased or prolonged opioid effects Details Hydrocodone Lacosamide Injection Motpoly An increased risk of CNS depression Details Hydrocodone Lenacapavir Injection Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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