Uva Ursi - Zohydro ER (Hydrocodone) Interaction
Herbal: Uva Ursi
Also Known As: Arctostaphylos uva-ursi, Arberry, Arbousier, Arbousier Traînant, Bear's Grape, Bearberry, Beargrape, Busserole, Common Bearberry, Faux Buis, Hogberry, Kinnikinnik, Manzanita, Mountain Box, Mountain Cranberry, Petit Buis, Ptarmigan Berry, Raisin de Renard, Raisin d'Ours
Drug: Hydrocodone
Brand names:
Hydrocodone, Zohydro ER
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Hydrocodone is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
Uva Ursi Overview
Uva ursi, also known as bearberry, is a plant species belonging to the Ericacea family, and is native to North America, Europe, and parts of Asia. It is a low-growing shrub with small, white flowers and edible red berries. The leaves of the plant are often used in traditional medicine as they are thought to have various medicinal properties, such as astringent, diuretic, and antimicrobial effects.
Medicinally, Uva ursi is most often used to treat urinary tract infections and other urinary problems, as well as skin conditions such as eczema and dermatitis. It is also sometimes used to promote weight loss and as a natural remedy for kidney stones. In dietary supplements, Uva ursi is often standardized with a specific amount of Arbutin (usually around 20%), a constituent of the plant.
Hydrocodone Overview
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Hydrocodone is used to relieve severe pain. Hydrocodone is only used to treat people who are expected to need medication to relieve severe pain around-the-clock for a long time and who cannot be treated with other medications or treatments. Hydrocodone extended-release (long-acting) capsules or extended-release tablets should not be used to treat pain that can be controlled by medication that is taken as needed. Hydrocodone is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.
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This monograph only includes information about the use of hydrocodone alone. If you are taking a hydrocodone combination product, be sure to read information about all the ingredients in the hydrocodone-combination monograph and ask your doctor or pharmacist for more information.
Uva Ursi - More Interactions
Uva Ursi interacts with 778 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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