Torsemide

61 interactions 4 explained in plain English

Also sold as: Soaanz Upcard

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Bromfenac Ophthalmic Methotrexate Injection Hydromorphone Rectal Arsenic Trioxide Aspirin

1 Contraindicated 41 Major 19 Moderate

All (61) Contraindicated (1) Major (41) Moderate (19)

Contraindicated

Torsemide Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details

Major

Torsemide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Torsemide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Torsemide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Torsemide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Torsemide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Torsemide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Torsemide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Torsemide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Torsemide Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Torsemide Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Torsemide Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Torsemide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Foscarnet Injection Foscavir Impaired foscarnet elimination and potential for toxicity Details Torsemide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Torsemide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Torsemide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Lithium Carbonate Lithobid An increased risk of lithium toxicity Details Torsemide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Torsemide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Torsemide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Torsemide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.