Drug & supplement interaction

Jequirity + Alogliptin, Metformin

Alogliptin, Metformin brand name: Kazano.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Jequirity has a moderate interaction with Alogliptin, Metformin. Evidence from animal research suggests that an extract of jequirity can reduce blood glucose levels.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jequirity and Alogliptin, Metformin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Alogliptin, Metformin

Alogliptin, Metformin falls under ANTIDIABETES DRUGS — the group Jequirity interacts with.

Evidence from animal research suggests that an extract of jequirity can reduce blood glucose levels. Theoretically, jequirity might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

First things first: I'd steer you away from jequirity altogether. Its seeds contain abrin, a poison closely related to ricin, and there's no safe, proven supplement version of it. That alone is reason enough to skip it.

On the interaction itself, this one is purely theoretical, based only on animal studies. The idea is that a jequirity extract might lower blood sugar on its own. Stacked on top of Kazano (alogliptin and metformin), which is already working to bring your numbers down, you could in theory drift too low. That's hypoglycemia, and with these drugs it can show up as shakiness, sweating, dizziness, or confusion. Please don't start, stop, or adjust anything on your own. Talk with your pharmacist or doctor, and keep an eye on your blood sugar readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Nwanjo HU. Hypoglycemic and hypolipidemic effects of aqueous extracts of Abrus precatorius Linn seeds in streptozotocin-induced diabetic Wistar rats. J Herbs Spice Med Plants 2008;14(1-2):68-76.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jequirity Also Interacts With Other Medications

Jequirity has 207 moderate, 603 minor known drug interactions in our database — the Alogliptin, Metformin one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 Minor 603 No known interaction 2,020 (incl. Alogliptin, Metformin)
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Alogliptin, Metformin

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alogliptin, Metformin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Alogliptin, Metformin page

“Kazano combines alogliptin and metformin to lower blood sugar, and nearly everything on this list pushes on that same lever, so I treat these pairings with real caution. Most entries are herbs and supplements that lower glucose on their own, and stacked on the drug they raise the risk of hypoglycemia, a sugar drop steep enough to cause…”

Reviewed by 2 · Jul 18, 2026

Open the Alogliptin, Metformin interaction page

How much people look this up

Where Jequirity and Alogliptin, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Steady interest

#1,149 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alogliptin, Metformin
Top half

#1,323 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Read the full Jequirity monograph & all interactions
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
603Minor
2,019No known interaction
207 Moderate 603 Minor 2,019 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Jequirity page.

Minor

603 interactions

Showing 60 of 603 minor interactions — see all 603 on the Jequirity page.

No interaction 2,019 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,019 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Alogliptin, Metformin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jequirity monograph › Uses, safety, and every drug interaction in one place Alogliptin, Metformin supplement interactions › Every supplement checked against Alogliptin, Metformin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jequirity and Alogliptin, Metformin Together: Common Questions

Can you take Jequirity with Alogliptin, Metformin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Jequirity and Alogliptin, Metformin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Alogliptin, Metformin and Jequirity?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.