Drug & supplement interaction

Jequirity + Hydrocodone Bitartrate

Hydrocodone Bitartrate brand names: Hysingla, Vantrela ER.

Minor Interaction
Medically reviewed by · Updated October 2026
The bottom line Minor

Jequirity has a minor interaction with Hydrocodone Bitartrate. In vitro research shows that jequirity extract inhibits CYP3A4 enzymes.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Jequirity and Hydrocodone Bitartrate

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Hydrocodone Bitartrate

Hydrocodone Bitartrate falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Jequirity interacts with.

In vitro research shows that jequirity extract inhibits CYP3A4 enzymes. Theoretically, taking jequirity may inhibit the metabolism of CYP3A4 substrates.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

First things first: jequirity seeds are genuinely poisonous (they contain abrin, a relative of ricin), so this isn't something I'd ever want you taking as a supplement at all. Setting that big safety issue aside, here's the specific interaction you asked about. Your body partly uses an enzyme called CYP3A4 to clear hydrocodone. Lab studies suggest jequirity can slow that enzyme down, which in theory could let hydrocodone build up a bit more than usual.

If that happened, you might feel more sedation, dizziness, slowed breathing, constipation, or nausea. I'll be honest, though: this is only test-tube evidence, the interaction is rated minor and unlikely, and the real danger here is jequirity's toxicity, not its effect on your pain medicine. Please loop in your pharmacist or doctor before combining anything with hydrocodone.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ai C, Miao X, Wang L, He J. Discovery and Activity Evaluation of the Inhibitory Effect of Four Kinds Traditional Chinese Medicine Extracts on the CYP3A4 Enzyme. Comb Chem High Throughput Screen 2022.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Jequirity Also Interacts With Other Medications

Jequirity has 208 moderate, 604 minor known drug interactions in our database — the Hydrocodone Bitartrate one above is one of them. If you take anything else, check it against the full list below.

Moderate 208 Minor 604 No known interaction 2,018 (incl. Hydrocodone Bitartrate)
Taking anything else?

Check Another of Your Medications Against Jequirity

Covers the 2,830 medications we’ve checked against Jequirity. Pick one to open its full report.

From our Q&A

Questions About Jequirity or Hydrocodone Bitartrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Jequirity or Hydrocodone Bitartrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Hydrocodone Bitartrate

This page covers Jequirity only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydrocodone Bitartrate page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

Open the Hydrocodone Bitartrate interaction page

How much people look this up

Where Jequirity and Hydrocodone Bitartrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Jequirity
Top half

#528 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydrocodone Bitartrate
Steady interest

#2,227 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Jequirity

What is Jequirity?

Jequirity
  • Asthma and cough
  • Fever
  • Sore throat and bronchitis
  • Liver complaints (hepatitis)
  • Constipation
  • Traditional infectious-disease remedies

Jequirity (Abrus precatorius) is a tropical plant whose bright red, black-tipped seeds contain abrin, one of the most toxic plant proteins known. Despite a long history in traditional medicine, the seeds are dangerously poisonous and there is no reliable evidence that it is safe or effective. It should not be used as a supplement or medicine.

Read the full Jequirity monograph & all interactions
Medication

About Hydrocodone

What Is Hydrocodone Used For?

Brand names: Hysingla, Vantrela ER

Hydrocodone extended-release products treat severe and persistent pain that needs a daily opioid pain reliever. They are for people whose pain can't be managed well with other treatments, including immediate-release opioids.

They are not meant to be used as an as-needed pain reliever. Hydrocodone bitartrate extended-release capsules are described for pain needing an extended treatment period. Hydrocodone bitartrate extended-release tablets and Hysingla ER are described for pain that can't be adequately treated with other options.

See full Hydrocodone drug information
Keep checking

Other Drugs & Jequirity

Browse every other medication we’ve checked against Jequirity — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
208Moderate
604Minor
2,017No known interaction
208 Moderate 604 Minor 2,017 No interaction
Moderate

208 interactions

Showing 60 of 208 moderate interactions — see all 208 on the Jequirity page.

Minor

604 interactions

Showing 60 of 604 minor interactions — see all 604 on the Jequirity page.

No interaction 2,017 drugs checked — show the list

We also checked Jequirity against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,017 medications checked with no known interaction — see the full Jequirity list.

See the full Jequirity interactions page
See every supplement checked against Hydrocodone Bitartrate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Jequirity monograph › Uses, safety, and every drug interaction in one place Hydrocodone Bitartrate supplement interactions › Every supplement checked against Hydrocodone Bitartrate, ranked by severity Hydrocodone drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Jequirity and Hydrocodone Bitartrate Together: Common Questions

Can you take Jequirity with Hydrocodone Bitartrate?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Jequirity and Hydrocodone Bitartrate interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydrocodone Bitartrate and Jequirity?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.