Drug & supplement interaction

Magnesium + Lidocaine

Lidocaine brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Magnesium and Lidocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Magnesium and Lidocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lidocaine and Magnesium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Magnesium safety at a glance

Magnesium overall Generally safe Generally safe for healthy adults when taken at recommended amounts from food and supplements.
Pregnancy Likely Safe When used orally and appropriately. Magnesium is safe for those pregnant and breast-feeding when used in doses below the tolerable upper intake level (UL) of 35... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately. Magnesium is safe for those pregnant and breast-feeding when used in doses below the tolerable upper intake level (UL) of 35... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lidocaine and Magnesium? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lidocaine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lidocaine is filed under 5 classifications — including anesthesia, cytochrome p450 2d6 (cyp2d6) substrates, topical drugs. Magnesium has documented interactions with 15 drug classes — the most serious being levodopa/carbidopa (sinemet) (major), aminoglycoside antibiotics (moderate) and antacids (moderate) — and none of Lidocaine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Magnesium Does Interact With Other Medications

Magnesium has 6 major, 175 moderate, 114 minor known drug interactions in our database — Lidocaine isn’t one of them. If you take anything else, check it against the full list below.

Major 6 Moderate 175 Minor 114 No known interaction 2,535 (incl. Lidocaine)
Taking anything else?

Check Another of Your Medications Against Magnesium

Covers the 2,830 medications we’ve checked against Magnesium. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Magnesium and Lidocaine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on Additional detail

    Magnesium

    “Intravenously, magnesium can cause bradycardia, tachycardia, and hypotension. Inhaled magnesium administered by nebulizer may also cause hypotension. Magnesium sulfate may cause rapid heartbeat when administered antenatally.

    In one case report, a 99-year-old male who took oral magnesium oxide 3000 mg daily for chronic constipation was hospitalized with hypermagnesemia, hypotension, bradycardia, heart failure, cardiom…”

    Magnesium · Natural Medicines adverse-effect record, reported in congestive heart failure (chf).

    6 sources cited
    1. 13356. Davey MJ, Teubner D. A randomized controlled trial of magnesium sulfate, in addition to usual care, for rate control in atrial fibrillation. Ann Emerg Med 2005;45:347-53.. PubMed
    2. 60795. Horner, S. M. Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality. Meta-analysis of magnesium in acute myocardial infarction. Circulation 1992;86(3):774-779. PubMed
    3. 60838. Henyan, N. N., Gillespie, E. L., White, C. M., Kluger, J., and Coleman, C. I. Impact of intravenous magnesium on post-cardiothoracic surgery atrial fibrillation and length of hospital stay: a meta-analysis. Ann.Thorac.Surg. 2005;80(6):2402-2406. PubMed
    4. 60872. Li, J., Zhang, Q., Zhang, M., and Egger, M. Intravenous magnesium for acute myocardial infarction. Cochrane.Database.Syst.Rev. 2007;(2):CD002755. PubMed
    5. 60960. Duley, L., Gulmezoglu, A. M., Henderson-Smart, D. J., and Chou, D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane.Database.Syst.Rev. 2010;(11):CD000025. PubMed
    6. 60973. Wong, G. K., Boet, R., Poon, W. S., Chan, M. T., Gin, T., Ng, S. C., and Zee, B. C. Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage: an updated systemic review and meta-analysis. Crit Care 2011;15(1):R52. PubMed

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Confusion Worth acting on Additional detail

    Magnesium

    “Intravenously, magnesium may cause slurred speech, dizziness, drowsiness, confusion, or headaches. With toxic doses, loss of reflexes, neurological defects, drowsiness, confusion, and coma can occur.

    A case report describes cerebral cortical and subcortical edema consistent with posterior reversible encephalopathy syndrome (PRES), eclampsia, somnolence, seizures, absent deep tendon reflexes, hard to control hypertens…”

    Magnesium · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 60818. Azria, E., Tsatsaris, V., Goffinet, F., Kayem, G., Mignon, A., and Cabrol, D. [Magnesium sulfate in obstetrics: current data]. J Gynecol.Obstet.Biol.Reprod.(Paris) 2004;33(6 Pt 1):510-517.
    2. 60960. Duley, L., Gulmezoglu, A. M., Henderson-Smart, D. J., and Chou, D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane.Database.Syst.Rev. 2010;(11):CD000025. PubMed
    3. 114681. Shepherd ES, Goldsmith S, Doyle LW, et al. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2024;5(5):CD004661. PubMed
    4. 8095. Birrer RB, Shallash AJ, Totten V. Hypermagnesemia-induced fatality following epsom salt gargles. J Emerg Med 2002;22:185-8. PubMed
    5. 12589. Jeyabalan A, Caritis SN. Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 2002;45:99-113. PubMed
    6. 12590. Mittendorf R, Dambrosia J, Pryde PG, et al. Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 2002;186:1111-8.. PubMed

    “A case of delirium due to hypermagnesemia has been reported for a patient receiving intravenous magnesium sulfate for pre-eclampsia.”

    Magnesium · Natural Medicines adverse-effect record, reported in pre-eclampsia.

    1 source cited
    1. 60780. Ganzevoort, J. W., Hoogerwaard, E. M., and van der Post, J. A. [Hypocalcemic delirium due to magnesium sulphate therapy in a pregnant woman with pre-eclampsia]. Ned.Tijdschr.Geneeskd. 8-3-2002;146(31):1453-1456.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Seizures Worth acting on Additional detail

    Magnesium

    Recorded for Magnesium in the same Natural Medicines adverse-effect record shown under Confusion above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Hives Worth acting on Additional detail

    Magnesium

    “Intravenously, magnesium may cause flushing, sweating, and problems at the injection site (including burning pain). In a case study, two patients who received intravenous magnesium sulfate for suppression of preterm labor developed a rapid and sudden onset of an urticarial eruption (a skin eruption of itching welts). The eruption cleared when magnesium sulfate was discontinued.”

    Magnesium · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    6 sources cited
    1. 60960. Duley, L., Gulmezoglu, A. M., Henderson-Smart, D. J., and Chou, D. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane.Database.Syst.Rev. 2010;(11):CD000025. PubMed
    2. 60982. Magee, L., Sawchuck, D., Synnes, A., and von, Dadelszen P. SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection. J Obstet.Gynaecol.Can. 2011;33(5):516-529.
    3. 111696. Enayati A, Gin JH, Sajeev JK, et al. Efficacy of intravenous magnesium for the management of non-post operative atrial fibrillation with rapid ventricular response: A systematic review and meta-analysis. J Cardiovasc Electrophysiol 2023;34(5):1286-1295. PubMed
    4. 114681. Shepherd ES, Goldsmith S, Doyle LW, et al. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev 2024;5(5):CD004661. PubMed
    5. 61045. Thorp, J. M., Jr., Katz, V. L., Campbell, D., and Cefalo, R. C. Hypersensitivity to magnesium sulfate. Am.J.Obstet.Gynecol. 1989;161(4):889-890. PubMed
    6. 98291. Sakanoue M, Sanada J, Kanekura T. Skin eruption elicited by magnesium oxide (Maglax). J Dermatol. 2016;43(2):221-2.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Bleeding or bruising Worth acting on Additional detail

    Magnesium

    “Intravenously, magnesium may cause increased blood loss at delivery when administered for eclampsia or pre-eclampsia. However, research on the effect of intravenous magnesium on postpartum hemorrhage is mixed.”

    Magnesium · Natural Medicines adverse-effect record, reported in pre-eclampsia.

    3 sources cited
    1. 12592. Witlin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 1998;92:883-9.. DOI
    2. 60982. Magee, L., Sawchuck, D., Synnes, A., and von, Dadelszen P. SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection. J Obstet.Gynaecol.Can. 2011;33(5):516-529.
    3. 97489. Miller ES, Sakowicz A, Leger E. Lange E, Yee LM. The association between receipt of intrapartum magnesium and postpartum hemorrhage. Am J Obstet Gynecol 2018;218(1 Suppl):S165.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Flushing Additional detail

    Magnesium

    Recorded for Magnesium in the same Natural Medicines adverse-effect record shown under A slow heartbeat above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Blurred vision / Tiredness reported in 5.1% of FDA reports for Lidocaine Additional detail

    Magnesium

    Recorded for Magnesium in the same Natural Medicines adverse-effect record shown under A slow heartbeat above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Low blood pressure Additional detail

    Magnesium

    Recorded for Magnesium in the same Natural Medicines adverse-effect record shown under A slow heartbeat above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

  • Drowsiness Additional detail

    Magnesium

    Recorded for Magnesium in the same Natural Medicines adverse-effect record shown under Confusion above.

    Lidocaine

    Listed in the ADVERSE REACTIONS section of the FDA label for Lidocaine. Read the label on DailyMed ›

Showing the 10 most notable of 17 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Magnesium but not commonly for Lidocaine: a bowel blockage, trouble passing urine, muscle weakness and kidney problems.

Effects for Lidocaine come from the ADVERSE REACTIONS section of its FDA label; effects for Magnesium come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 96,036 voluntary FDA FAERS reports for Lidocaine that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Magnesium in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately. Magnesium is safe for those pregnant and breast-feeding when used in doses below the tolerable upper intake level (UL) of 350 mg daily.

Pregnancy And Lactation Possibly Safe

When prescription magnesium sulfate is given intramuscularly and intravenously prior to delivery for up to 5 days. However, due to potential adverse effects associated with intravenous and intramuscular magnesium, use during pregnancy is limited to patients with specific conditions such as severe pre-eclampsia or eclampsia. There is some evidence that intravenous magnesium can increase fetal mortality and adversely affect neurological and skeletal development. However, a more recent analysis of clinical research shows that increased risk of fetal mortality seems to occur only in the studies where antenatal magnesium is used for tocolysis and not for fetal neuroprotection or pre-eclampsia/eclampsia. Furthermore, antenatal magnesium does not seem to be associated with increased risk of necrotizing enterocolitis in preterm infants. There is also concern that magnesium increases the risk of maternal adverse events. A meta-analysis of clinical research shows that magnesium sulfate might increase the risk of maternal adverse events, especially in Hispanic mothers compared to other racial and ethnic groups.

Pregnancy And Lactation Possibly Unsafe

When used orally in excessive doses. Tell patients to avoid exceeding the tolerable upper intake level (UL) of 350 mg daily. Taking magnesium orally in higher doses can cause diarrhea. ...when prescription magnesium sulfate is given intramuscularly and intravenously prior to delivery for longer than 5 days. Maternal exposure to magnesium for longer than 5-7 days is associated with an increase in neonatal bone abnormalities such as osteopenia and fractures. The U.S. Food and Drug Administration (FDA) recommends that magnesium injection not be given for longer than 5-7 days.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Magnesium or Lidocaine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Magnesium or Lidocaine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lidocaine

This page covers Magnesium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lidocaine page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 111 moderate · 31 minor.

From our pharmacist’s overview on the Lidocaine page

“Lidocaine (Xylocaine) deserves genuine care on this page, and I would learn its three major-rated entries first. Grapefruit and St.”

Reviewed by 2 · Jul 18, 2026

Open the Lidocaine interaction page

One more smart check

Taking Magnesium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 29,717 real supplement products containing Magnesium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Magnesium. Even though Magnesium itself has no known interaction with Lidocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Magnesium and Lidocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Magnesium
Top 10

#4 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lidocaine
Top 25%

#430 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Magnesium reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Magnesium and Lidocaine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Magnesium

What is Magnesium?

Magnesium
  • Preventing or treating magnesium deficiency
  • Constipation
  • Muscle cramps
  • Sleep support
  • Anxiety and stress
  • Migraine prevention

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some other uses, like easing constipation or preventing migraines, have reasonable support, while uses for sleep and anxiety are less proven. It is generally safe for most healthy people at recommended amounts, but talk to your pharmacist or doctor before starting, especially if you have kidney problems.

Mineral (not a plant part) · Tablets, capsules, powders, liquids, gummies, and topical Epsom salts; common forms include magnesium citrate, glycinate, oxide, chloride, malate, and aspartate

An interaction check asks whether these two react with each other — it does not ask whether Magnesium is a good idea for someone in your situation. Here is what our Magnesium record says about it on its own.

Magnesium: dosing

There is no single "best" dose for everyone, and the right amount depends on your age, sex, health, and the reason you are taking it. Different forms contain different amounts of actual (elemental) magnesium, which can be confusing.Do not assume more is better. There is an upper limit for magnesium taken as a supplement, and going above it raises the risk of side effects. If you are using magnesium for a specific condition like constipation or migraine, ask a health professional for guidance.

From our Magnesium monograph — the full record covers uses, side effects and every documented interaction.

Read the full Magnesium monograph & all interactions
Medication

About Lidocaine Transdermal Patch

What Is Lidocaine Transdermal Patch Used For?

Brand names: Xylocaine, Dilocaine, Lidoject-1, Xylocaine MPF, Nervocaine, Lidoject-2, Duo-Trach Kit, Octocaine, Lidoderm, Ztlido

Lidocaine skin patches are applied directly to the painful area to treat post-herpetic neuralgia (PHN) — the persistent burning or aching nerve pain that can remain after a shingles outbreak.

Lidoderm (lidocaine patch 5%) and ZTlido (lidocaine topical system 1.8%) are both indicated for this use in adults. Note that despite their different strengths, one ZTlido topical system provides equivalent lidocaine exposure to one Lidoderm patch.

Most-Reported Side Effects for Lidocaine

From FAERS, the FDA’s public side-effect reporting system (96,036 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,961 reports
Fatigue 4,867 reports
Headache 4,439 reports
Product quality issue 3,920 reports
Dyspnea 3,658 reports
See full Lidocaine Transdermal Patch drug information
Keep checking

Other Drugs & Magnesium

Browse every other medication we’ve checked against Magnesium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

6Major
175Moderate
114Minor
2,534No known interaction
6 Major 175 Moderate 114 Minor 2,534 No interaction
Major

6 interactions

Moderate

175 interactions

Showing 60 of 175 moderate interactions — see all 175 on the Magnesium page.

Minor

114 interactions

Showing 60 of 114 minor interactions — see all 114 on the Magnesium page.

No interaction 2,534 drugs checked — show the list

We also checked Magnesium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,534 medications checked with no known interaction — see the full Magnesium list.

See the full Magnesium interactions page
See every supplement checked against Lidocaine, ranked by severity
Evidence & sources

Magnesium References

The 82 references that drive our Magnesium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rodin SM, Johnson BF. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-44.
  2. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  3. Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-80. PubMed
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. Peikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 1996;16:257-63. PubMed
  6. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063507/html/index.html.
  7. Birrer RB, Shallash AJ, Totten V. Hypermagnesemia-induced fatality following epsom salt gargles. J Emerg Med 2002;22:185-8. PubMed
  8. Ryan MP. Diuretics and potassium/magnesium depletion. Directions for treatment. Am J Med 1987;82:38-47.. PubMed
  9. Hollifield JW. Magnesium depletion, diuretics, and arrhythmias. Am J Med 1987;82:30-7.. PubMed
  10. Heidenreich O. Mode of action of conventional and potassium-sparing diuretics--aspects with relevance to Mg-sparing effects. Magnesium 1984;3:248-56..
  11. Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of migraine--a double-blind placebo-controlled study. Cephalalgia 1996;16:436-40.. PubMed
  12. Wang F, Van Den Eeden SK, Ackerson LM, et al. Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 2003;43:601-10.. PubMed
  13. Sompolinsky D, Samra Z. Influence of magnesium and manganese on some biological and physical properties of tetracycline. J Bacteriol 1972;110:468-76.. PubMed
  14. Jeyabalan A, Caritis SN. Pharmacologic inhibition of preterm labor. Clin Obstet Gynecol 2002;45:99-113. PubMed
  15. Mittendorf R, Dambrosia J, Pryde PG, et al. Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 2002;186:1111-8.. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Magnesium and Lidocaine Together: Common Questions

Is it safe to take Magnesium with Lidocaine?
We do not list a known interaction between Magnesium and Lidocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Magnesium and Lidocaine have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Magnesium and Lidocaine combination checked?
Interactions in our licensed database are recorded against drug classes. Lidocaine is filed under 5 classifications, and Magnesium has documented interactions with 15 drug classes — none of Lidocaine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Magnesium interact with any other medications?
Yes. Magnesium has 295 documented drug interactions in our database — Lidocaine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lidocaine interact with any supplements?
Yes. Lidocaine has documented interactions with 145 supplements in our database — Magnesium is not one of them. The Lidocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Magnesium monograph Uses, safety profile, and every drug interaction in one place Lidocaine Transdermal Patch drug information The full plain-English guide to this medication Lidocaine supplement interactions Every supplement checked against Lidocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 82 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lidocaine and Magnesium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.