Drug & supplement interaction

Masterwort + Sulfadiazine

Sulfadiazine brand name: Sulfadiazine.

Moderate Interaction
Medically reviewed by · Updated June 2025
The bottom line Moderate

Masterwort has a moderate interaction with Sulfadiazine. The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Masterwort and Sulfadiazine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

PHOTOSENSITIZING DRUGS

Why this applies to Sulfadiazine

Sulfadiazine falls under PHOTOSENSITIZING DRUGS — the group Masterwort interacts with.

The use of masterwort in conjunction with photosensitizing drugs is contraindicated due to the potential for additive photosensitizing effects.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to know about pairing masterwort with sulfadiazine. This isn't about masterwort changing how your body breaks down the antibiotic. Instead, both can make your skin more sensitive to sunlight. Sulfadiazine, like many sulfa drugs, already carries a known risk of photosensitivity, meaning you can sunburn faster or break out in a rash with sun exposure. Masterwort contains furanocoumarins, the same compounds in grapefruit and other carrot-family plants, which can add to that effect.

So putting them together could mean an easier, worse sunburn or skin reaction. This is a reasonable concern based on how both work, though it's more theory than proven cases. Stay covered up and use sunscreen, and check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Masterwort Also Interacts With Other Medications

Masterwort has 334 moderate known drug interactions in our database — the Sulfadiazine one above is one of them. If you take anything else, check it against the full list below.

Moderate 334 No known interaction 2,496 (incl. Sulfadiazine)
Taking anything else?

Check Another of Your Medications Against Masterwort

Covers the 2,830 medications we’ve checked against Masterwort. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Sulfadiazine

This page covers Masterwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sulfadiazine page lists 107 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Para-aminobenzoic Acid (paba) (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 91 moderate · 11 minor.

From our pharmacist’s overview on the Sulfadiazine page

“Sulfadiazine treats serious infections like toxoplasmosis, often over long courses, and its list of 107 interacting supplements calls for real care. The most direct problem is PABA, sold as a B-vitamin relative, because it can blunt sulfadiazine's antibacterial effect outright.”

Reviewed by 2 · Jul 18, 2026

Open the Sulfadiazine interaction page

How much people look this up

Where Masterwort and Sulfadiazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Masterwort
Top half

#520 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sulfadiazine
Top half

#850 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Masterwort

What is Masterwort?

Masterwort
  • Digestive upset
  • Mild anxiety and tension
  • Skin complaints
  • Respiratory and cough relief
  • Traditional tonic

Masterwort (Heracleum sphondylium), a plant in the carrot family, has a long folk-medicine history for digestion, nerves, and skin. Modern scientific evidence to support these uses is very limited, and the plant can cause skin reactions to sunlight, so use it cautiously and talk with your pharmacist or doctor first.

Read the full Masterwort monograph & all interactions
Medication

About Sulfadiazine

What Is Sulfadiazine Used For?

Brand name: Sulfadiazine

Sulfadiazine tablets treat a range of infections. These include chancroid, trachoma, inclusion conjunctivitis, nocardiosis, and certain urinary tract infections caused by susceptible bacteria.

It is also used alongside other medicines for toxoplasmosis encephalitis, malaria from chloroquine-resistant Plasmodium falciparum, acute middle ear infection, and H. influenzae meningitis. It can also help prevent meningococcal meningitis and rheumatic fever recurrences.

See full Sulfadiazine drug information
Keep checking

Other Drugs & Masterwort

Browse every other medication we’ve checked against Masterwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
334Moderate
0Minor
2,495No known interaction
334 Moderate 2,495 No interaction
Moderate

334 interactions

Showing 60 of 334 moderate interactions — see all 334 on the Masterwort page.

No interaction 2,495 drugs checked — show the list

We also checked Masterwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,495 medications checked with no known interaction — see the full Masterwort list.

See the full Masterwort interactions page
See every supplement checked against Sulfadiazine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Masterwort monograph › Uses, safety, and every drug interaction in one place Sulfadiazine supplement interactions › Every supplement checked against Sulfadiazine, ranked by severity Sulfadiazine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Masterwort and Sulfadiazine Together: Common Questions

Can you take Masterwort with Sulfadiazine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Masterwort and Sulfadiazine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Sulfadiazine and Masterwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.