Medication interaction hub

What Supplements Interact with Guanadrel Sulfate?

Guanadrel Sulfate brand name: Hylorel. Every interaction below applies to the brands too.

137 Interactions 4 Major 112 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guanadrel Sulfate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guanadrel Sulfate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People taking guanadrel sulfate (Hylorel) are working to hold blood pressure in a steady range, and that is precisely what most of the 137 supplements on this list disturb, so it warrants genuine vigilance. Nearly all of them push pressure one way or the other, either stacking with guanadrel until it drops too far or working against it and letting pressure climb. Four are rated major, and those deserve attention first: tyramine, the same compound found in aged and fermented foods, can drive blood pressure up sharply, while activated charcoal can pull the drug out of the body before it can act.

Everyday items make up much of the middle ground. Fish oil, celery seed extract, and similar heart-friendly staples account for many of the 112 moderate entries through added pressure lowering, and a smaller set of 17 can change how oral medicines absorb at all, so space those well away from each dose. Twenty-one more rate only minor, but a drug this dependent on steady blood pressure leaves little room for surprises.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 112 Minor 21 No known interaction 1,315

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Guanadrel Sulfate: Top Interactions at a Glance

The Guanadrel Sulfate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 137 interacting ingredients — plus 1,315 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Guanadrel Sulfate Combinations Today

The Guanadrel Sulfate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Agmatine + Guanadrel Sulfatei

Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Black Seed + Guanadrel Sulfatei

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Khat + Guanadrel Sulfatei

Human research shows that khat and its constituent, cathinone, can increase blood pressure.

Read the full interaction Moderate Likelihood Possible Tribulus + Guanadrel Sulfatei

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Major Likelihood Likely American Hellebore + Guanadrel Sulfatei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Tyramine + Guanadrel Sulfatei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Guanadrel Sulfate

All 1,452 ingredients in our database, ranked by severity — 137 with a Guanadrel Sulfate interaction on file and 1,315 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guanadrel Sulfate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Agmatine with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Guanadrel Sulfate answer

Can you take Black Seed with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Guanadrel Sulfate answer

Can you take Khat with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Human research shows that khat and its constituent, cathinone, can increase blood pressure.

Full Khat + Guanadrel Sulfate answer

Can you take Tribulus with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Guanadrel Sulfate answer

Can you take American Hellebore with Guanadrel Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Full American Hellebore + Guanadrel Sulfate answer

Can you take Tyramine with Guanadrel Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Full Tyramine + Guanadrel Sulfate answer

Can you take Activated Charcoal with Guanadrel Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Guanadrel Sulfate answer

Can you take American Mistletoe with Guanadrel Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially...

Full American Mistletoe + Guanadrel Sulfate answer

Can you take Apple with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Full Apple + Guanadrel Sulfate answer

Can you take Banaba with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and antihypertensive drugs might cause additive effects.

Full Banaba + Guanadrel Sulfate answer

Can you take Beer with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Beer + Guanadrel Sulfate answer

Can you take Casein Peptides with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.

Full Casein Peptides + Guanadrel Sulfate answer

Can you take Cat's Claw with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.

Full Cat's Claw + Guanadrel Sulfate answer

Can you take Celery with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Guanadrel Sulfate answer

Can you take Coca with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antihypertensive drugs.

Full Coca + Guanadrel Sulfate answer

Can you take Cod Liver Oil with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.

Full Cod Liver Oil + Guanadrel Sulfate answer

Can you take Coffee Charcoal with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Guanadrel Sulfate answer

Can you take Docosahexaenoic Acid (dha) with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Guanadrel Sulfate answer

Can you take Eicosapentaenoic Acid (epa) with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Full Eicosapentaenoic Acid (epa) + Guanadrel Sulfate answer

Can you take European Mandrake with Guanadrel Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Guanadrel Sulfate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guanadrel Sulfate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guanadrel Sulfate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guanadrel Sulfate sits in 3 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Guanadrel Sulfate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guanadrel Sulfate through this category.

Alpha-Adrenergic Antagonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Guanadrel Sulfate through this category.

Related: does Guanadrel Sulfate deplete any nutrients?

Guanadrel Sulfate has 1 reported nutrient association in the research literature — see the Guanadrel Sulfate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Guanadrel Sulfate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guanadrel Sulfate.

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Products that contain Guanadrel Sulfate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Guanadrel Sulfate.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Guanadrel Sulfate & Supplements: Common Questions

What supplements interact with Guanadrel Sulfate?
More than you might expect — 137 in total, though they are far from equal: 4 are rated major, 112 moderate, and 21 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Guanadrel Sulfate supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal and American Mistletoe. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Guanadrel Sulfate?
Usually yes — most people on Guanadrel Sulfate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Hylorel have the same supplement interactions as Guanadrel Sulfate?
Yes — Hylorel all contain Guanadrel Sulfate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Guanadrel Sulfate deplete any vitamins or nutrients?
It might — Guanadrel Sulfate has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Guanadrel Sulfate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Guanadrel Sulfate and my other medications?
This page covers Guanadrel Sulfate against supplements and herbal ingredients. Checking Guanadrel Sulfate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.