Medication interaction hub

What Supplements Interact with Reserpine?

Reserpine brand names: Serpasil, Sandril. Every interaction below applies to the brands too.

138 Interactions 4 Major 113 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Reserpine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Reserpine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Reserpine (Serpasil, Sandril) lowers blood pressure, and the 138 supplements and herbs listed here merit real vigilance, four of them rated major. Most pull in one of two directions: many common supplements lower pressure on their own and can add to reserpine's effect, dropping it too far, while a smaller group raises pressure and works against the drug. Tyramine does the latter. American hellebore is the most hazardous entry, its alkaloids drop blood pressure and depress the heart even in tiny amounts.

Absorption is the second theme. Activated charcoal, another of the majors, can soak up reserpine in the gut and cut the amount reaching your blood, and about seventeen entries affect oral medicines this way; give them a wide berth in timing. The other 113 moderate and 21 minor entries are largely milder versions of the additive pressure drop, which shows up as dizziness or lightheadedness when you stand.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 113 Minor 21 No known interaction 1,314

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Reserpine: Top Interactions at a Glance

The Reserpine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 138 interacting ingredients — plus 1,314 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Reserpine Combinations Today

The Reserpine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Coca + Reserpinei

Theoretically, coca might reduce the effects of antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Gentian + Reserpinei

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Probable Wine + Reserpinei

Theoretically, concomitant use may interfere with blood pressure control.

Read the full interaction Moderate Likelihood Possible Soy + Reserpinei

Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Kiwi + Reserpinei

Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Read the full interaction Moderate Likelihood Possible Melatonin + Reserpinei

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Read the full interaction
The complete list

Every Supplement Checked Against Reserpine

All 1,452 ingredients in our database, ranked by severity — 138 with a Reserpine interaction on file and 1,314 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Reserpine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coca with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antihypertensive drugs.

Full Coca + Reserpine answer

Can you take Gentian with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.

Full Gentian + Reserpine answer

Can you take Wine with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Wine + Reserpine answer

Can you take Soy with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.

Full Soy + Reserpine answer

Can you take Kiwi with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Clinical research suggests that consuming kiwi reduces systolic and diastolic blood pressure in hypertensive individuals.

Full Kiwi + Reserpine answer

Can you take American Hellebore with Reserpine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Full American Hellebore + Reserpine answer

Can you take Tyramine with Reserpine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Full Tyramine + Reserpine answer

Can you take Activated Charcoal with Reserpine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Reserpine answer

Can you take American Mistletoe with Reserpine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially...

Full American Mistletoe + Reserpine answer

Can you take Apple with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.

Full Apple + Reserpine answer

Can you take Banaba with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of banaba and antihypertensive drugs might cause additive effects.

Full Banaba + Reserpine answer

Can you take Beer with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with blood pressure control.

Full Beer + Reserpine answer

Can you take Casein Peptides with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining these casein peptides with antihypertensive drugs might increase the risk of hypotension.

Full Casein Peptides + Reserpine answer

Can you take Cat's Claw with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.

Full Cat's Claw + Reserpine answer

Can you take Celery with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, celery seed extract might have additive effects with antihypertensive drugs.

Full Celery + Reserpine answer

Can you take Cod Liver Oil with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.

Full Cod Liver Oil + Reserpine answer

Can you take Coffee Charcoal with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Reserpine answer

Can you take Docosahexaenoic Acid (dha) with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.

Full Docosahexaenoic Acid (dha) + Reserpine answer

Can you take Eicosapentaenoic Acid (epa) with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking EPA with antihypertensive drugs might increase the risk of hypotension.

Full Eicosapentaenoic Acid (epa) + Reserpine answer

Can you take European Mandrake with Reserpine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Reserpine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Reserpine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Reserpine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Reserpine sits in 4 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Reserpine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Reserpine through this category.

Alpha-Adrenergic Antagonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Reserpine through this category.

Reserpine (Raudixin, Others) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Reserpine through this category.

About Reserpine

Reserpine is a prescription medication also sold under the brand names Serpasil, Sandril. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Reserpine  ·  Brand names: Serpasil, Sandril.

See the full Reserpine drug information

Related: does Reserpine deplete any nutrients?

Reserpine has 2 reported nutrient associations in the research literature — see the Reserpine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Reserpine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Reserpine.

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Products that contain Reserpine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Reserpine.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Reserpine & Supplements: Common Questions

What supplements interact with Reserpine?
More than you might expect — 138 in total, though they are far from equal: 4 are rated major, 113 moderate, and 21 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Reserpine supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal and American Mistletoe. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Reserpine?
Usually yes — most people on Reserpine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Serpasil have the same supplement interactions as Reserpine?
Yes — Serpasil, Sandril all contain Reserpine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Reserpine deplete any vitamins or nutrients?
It might — Reserpine has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Reserpine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Reserpine and my other medications?
This page covers Reserpine against supplements and herbal ingredients. Checking Reserpine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Reserpine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.