Medication interaction hub

What Supplements Interact with Guanfacine?

Guanfacine brand name: Tenex. Every interaction below applies to the brands too.

136 Interactions 4 Major 111 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Guanfacine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Guanfacine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

136 supplements and herbal ingredients have interactions with Guanfacine on file in the HelloPharmacist interaction database — 4 rated major, 111 moderate, and 21 minor. The most serious involve American Hellebore, Tyramine, Activated Charcoal and American Mistletoe.

Our assessment: with 4 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Guanfacine.

Major 4 Moderate 111 Minor 21 No known interaction 1,316

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Guanfacine: Top Interactions at a Glance

The Guanfacine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 136 interacting ingredients — plus 1,316 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Guanfacine Combinations Today

The Guanfacine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Seed + Guanfacinei

Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Melatonin + Guanfacinei

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Read the full interaction Moderate Likelihood Probable Yohimbe + Guanfacinei

Theoretically, yohimbe might reduce the effects of antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Berberine + Guanfacinei

Theoretically, berberine might have additive effects with antihypertensive drugs.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Guanfacinei

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction Moderate Likelihood Possible Reishi Mushroom + Guanfacinei

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction
The complete list

Every Supplement Checked Against Guanfacine

All 1,452 ingredients in our database, ranked by severity — 136 with a Guanfacine interaction on file and 1,316 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Guanfacine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Seed with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black seed with antihypertensive drugs might increase the risk of hypotension.

Full Black Seed + Guanfacine answer

Can you take Melatonin with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.

Full Melatonin + Guanfacine answer

Can you take Yohimbe with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might reduce the effects of antihypertensive drugs.

Full Yohimbe + Guanfacine answer

Can you take Berberine with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might have additive effects with antihypertensive drugs.

Full Berberine + Guanfacine answer

Can you take Ashwagandha with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.

Full Ashwagandha + Guanfacine answer

Can you take Agmatine with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypotension when taken with antihypertensive drugs.

Full Agmatine + Guanfacine answer

Can you take Algal Oil with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.

Full Algal Oil + Guanfacine answer

Can you take Andrographis with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might increase the risk of hypotension when used with antihypertensive drugs.

Full Andrographis + Guanfacine answer

Can you take Artichoke with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.

Full Artichoke + Guanfacine answer

Can you take Asafoetida with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that asafoetida has hypotensive effects.

Full Asafoetida + Guanfacine answer

Can you take Ash with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ash seed with antihypertensive drugs might have additive blood pressure lowering effects.

Full Ash + Guanfacine answer

Can you take Baikal Skullcap with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotensi...

Full Baikal Skullcap + Guanfacine answer

Can you take Basil with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, basil might increase the risk of hypotension when taken with antihypertensive drugs.

Full Basil + Guanfacine answer

Can you take Beta-glucans with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.

Full Beta-glucans + Guanfacine answer

Can you take Betony with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, betony might have additive effects with blood pressure lowering drugs due to hypotensive activity of the glycosides found in...

Full Betony + Guanfacine answer

Can you take Blue Cohosh with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Constituents in blue cohosh might increase blood pressure by causing coronary vasoconstriction.

Full Blue Cohosh + Guanfacine answer

Can you take Breadfruit with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.

Full Breadfruit + Guanfacine answer

Can you take Bridelia with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Bridelia extracts decrease arterial pressure.

Full Bridelia + Guanfacine answer

Can you take Calamus with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with other antihypertensive medications might increase the risk of hypotension.

Full Calamus + Guanfacine answer

Can you take Cannabigerol (cbg) with Guanfacine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cannabigerol with antihypertensive drugs might increase the risk of hypotension.

Full Cannabigerol (cbg) + Guanfacine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Guanfacine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Guanfacine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Guanfacine sits in 2 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Guanfacine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Guanfacine through this category.

About Guanfacine

Guanfacine is a centrally acting alpha-adrenergic medication used to treat high blood pressure and ADHD symptoms.

Generic name: Guanfacine  ·  Brand name: Tenex.

See the full Guanfacine drug information

Related: does Guanfacine deplete any nutrients?

Guanfacine has 1 reported nutrient association in the research literature — see the Guanfacine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Guanfacine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Guanfacine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Guanfacine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Guanfacine.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Guanfacine & Supplements: Common Questions

What supplements interact with Guanfacine?
Our database currently documents 136 ingredients with a known Guanfacine interaction (4 major, 111 moderate, 21 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 136. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Guanfacine supplement interactions are the most serious?
The 4 major-rated combinations — led by American Hellebore, Tyramine, Activated Charcoal and American Mistletoe — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Guanfacine?
Plenty of supplements coexist fine with Guanfacine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Tenex have the same supplement interactions as Guanfacine?
Yes — Tenex all contain Guanfacine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Guanfacine deplete any vitamins or nutrients?
It might — Guanfacine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Guanfacine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Guanfacine and my other medications?
This page covers Guanfacine against supplements and herbal ingredients. Checking Guanfacine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Guanfacine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.