Medication interaction hub

What Supplements Interact with Hydrocodone, Pseudoephedrine?

Hydrocodone, Pseudoephedrine brand names: P-V-Tussin, Rezira. Every interaction below applies to the brands too.

241 Interactions 13 Major 190 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated October 6, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Hydrocodone, Pseudoephedrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Hydrocodone, Pseudoephedrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Rezira and P-V-Tussin pair hydrocodone, an opioid, with pseudoephedrine, a decongestant, so the 241 supplements here pull in two directions and I would handle this combination with real care. Most entries either deepen the opioid's sedation (78 ingredients are CNS depressants, alcohol included) or stack stimulant effects onto the pseudoephedrine, pushing blood pressure and heart rate up. Another large group changes how your body clears the hydrocodone; grapefruit can raise its level while St. John's wort can lower it.

Thirteen of the 241 rate major, and those deserve your attention before the rest. Anything sedating carries the most danger, because an opioid plus another depressant can slow your breathing, not just make you drowsy. On the stimulant side, even everyday caffeine lands among the 190 moderates, so if a supplement leaves you jittery or your heart racing on this medicine, treat that as a warning and not a quirk.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 190 Minor 38 No known interaction 1,211

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Hydrocodone, Pseudoephedrine: Top Interactions at a Glance

The Hydrocodone, Pseudoephedrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 241 interacting ingredients — plus 1,211 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Hydrocodone, Pseudoephedrine Combinations Today

The Hydrocodone, Pseudoephedrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Major Likelihood Probable St. John's Wort + Hydrocodone, Pseudoephedrinei

St.

Read the full interaction Moderate Likelihood Possible Quercetin + Hydrocodone, Pseudoephedrinei

Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Hydrocodone, Pseudoephedrinei

Theoretically, concomitant use might cause additive effects.

Read the full interaction Moderate Likelihood Probable Cannabidiol (cbd) + Hydrocodone, Pseudoephedrinei

Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Goji + Hydrocodone, Pseudoephedrinei

Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Read the full interaction Major Likelihood Likely Beer + Hydrocodone, Pseudoephedrinei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Hydrocodone, Pseudoephedrine

All 1,452 ingredients in our database, ranked by severity — 241 with a Hydrocodone, Pseudoephedrine interaction on file and 1,211 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Hydrocodone, Pseudoephedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take St. John's Wort with Hydrocodone, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Hydrocodone, Pseudoephedrine answer

Can you take Quercetin with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

Full Quercetin + Hydrocodone, Pseudoephedrine answer

Can you take Rauvolfia Vomitoria with Hydrocodone, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use might cause additive effects.

Full Rauvolfia Vomitoria + Hydrocodone, Pseudoephedrine answer

Can you take Cannabidiol (cbd) with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Hydrocodone, Pseudoephedrine answer

Can you take Goji with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Full Goji + Hydrocodone, Pseudoephedrine answer

Can you take Poria Mushroom with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.

Full Poria Mushroom + Hydrocodone, Pseudoephedrine answer

Can you take Propolis with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.

Full Propolis + Hydrocodone, Pseudoephedrine answer

Can you take Rabdosia Rubescens with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Hydrocodone, Pseudoephedrine answer

Can you take Raspberry Ketone with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Hydrocodone, Pseudoephedrine answer

Can you take Rauwolscine with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Hydrocodone, Pseudoephedrine answer

Can you take Resveratrol with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Hydrocodone, Pseudoephedrine answer

Can you take Rooibos with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.

Full Rooibos + Hydrocodone, Pseudoephedrine answer

Can you take Saffron with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.

Full Saffron + Hydrocodone, Pseudoephedrine answer

Can you take Sage with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.

Full Sage + Hydrocodone, Pseudoephedrine answer

Can you take Sassafras with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Hydrocodone, Pseudoephedrine answer

Can you take Sceletium with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.

Full Sceletium + Hydrocodone, Pseudoephedrine answer

Can you take Schizonepeta with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6.

Full Schizonepeta + Hydrocodone, Pseudoephedrine answer

Can you take Securinega Suffruticosa with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Hydrocodone, Pseudoephedrine answer

Can you take Shepherd's Purse with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Hydrocodone, Pseudoephedrine answer

Can you take Shiitake Mushroom with Hydrocodone, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Full Shiitake Mushroom + Hydrocodone, Pseudoephedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Hydrocodone, Pseudoephedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Hydrocodone, Pseudoephedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Hydrocodone, Pseudoephedrine sits in 9 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Hydrocodone, Pseudoephedrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrocodone, Pseudoephedrine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Hydrocodone, Pseudoephedrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Hydrocodone, Pseudoephedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Hydrocodone, Pseudoephedrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Hydrocodone, Pseudoephedrine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Hydrocodone, Pseudoephedrine.

Yeast-Cleanse by Solaray contains Grapefruit Ultimate GCB by M3 Supplement Company contains Grapefruit Neuro Health by Nature’s Craft contains Grapefruit NDF Happy Peach by Bioray Kids contains Grapefruit
Pharmacist Counseling Corner

Hydrocodone, Pseudoephedrine & Supplements: Common Questions

What supplements interact with Hydrocodone, Pseudoephedrine?
More than you might expect — 241 in total, though they are far from equal: 13 are rated major, 190 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Grapefruit, Wine.
Which Hydrocodone, Pseudoephedrine supplement interactions are the most serious?
Focus on the major group: Beer, Grapefruit, Wine, 1,4-butanediol and Activated Charcoal, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Hydrocodone, Pseudoephedrine?
Usually yes — most people on Hydrocodone, Pseudoephedrine can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like P-V-Tussin have the same supplement interactions as Hydrocodone, Pseudoephedrine?
Yes — P-V-Tussin, Rezira all contain Hydrocodone, Pseudoephedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Hydrocodone, Pseudoephedrine and my other medications?
This page covers Hydrocodone, Pseudoephedrine against supplements and herbal ingredients. Checking Hydrocodone, Pseudoephedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 6, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.