Major interaction on record — check this product against your medications before combining. Based on 1 of 7 ingredients. Check your meds →
Dietary supplement

Atro-phex Ingredients & Drug Interactions

by BSN

Atro-phex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Atro-phex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Atro-phex is a dietary supplement by BSN with 7 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,495 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Atro-phex by BSN

Ask about any prescription or over-the-counter medication and we check it for interactions with Atro-phex by BSN — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Atro-phex by BSN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 24 active ingredients.
  • “ATRO-PHEX - EXTREME ENERGY & WEIGHT MANAGEMENT TECHNOLOGY” is listed as a grouped ingredient — the label gives one combined amount (680 mg) without saying how much of each component you get.
  • “Adipose Atrophy & Energy Stimulation Composite” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “i-FAS50” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Atro-phex contains 24 ingredients, including several active compounds. Vitamin B6 supports energy metabolism and brain function.

Dandelion is a plant used traditionally for digestion and as a diuretic. Hordenine and beta-phenylethylamine are stimulant-type compounds.

Green tea provides antioxidants and mild stimulant effects from caffeine. Bitter orange (two forms, including Advantra Z) contains synephrine, a stimulant.

Black pepper (Bioperine) is added to enhance absorption of other ingredients. Red raspberry leaf is included for general wellness.

Lesser periwinkle contains alkaloids for potential cognitive effects. The product also contains caffeine directly (methylxanthine), along with N-acetyl-L-tyrosine and several botanical extracts in proprietary blends.

The inactive ingredients listed are magnesium stearate, FD&C colorants (Blue #1 and Red #40), titanium dioxide, and gelatin capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Neonatal apnea — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Postoperative headache — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Pyridoxine-dependent epilepsy — rated "Effective" (Vitamin B6) (Natural Medicines).

The evidence for Atro-phex's active ingredients is mixed and often limited. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, and likely effective for lowering homocysteine; it's possibly effective for pregnancy-related nausea.

Green tea is likely effective for HPV-related conditions and possibly effective for cholesterol and ovarian cancer risk. Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance.

For most other ingredients, the evidence we hold doesn't establish effectiveness: dandelion, bitter orange, black pepper, red raspberry leaf, lesser periwinkle, and 7-keto-DHEA are all rated as having insufficient reliable evidence for the conditions cited. Hordenine and several other components have no effectiveness ratings on file.

This product is marketed for weight management and energy, but the data does not support clear benefits for those purposes.

The evidence, ingredient by ingredient Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 13 of the 13 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 13.
  • General safety write-ups exist for 13 of 13.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily, though high doses over time can damage nerves (a rare serious effect at very high intakes). Common side effects include headache, nausea, and abdominal pain.

Caffeine is generally safe in moderate amounts for healthy adults but can cause anxiety, insomnia, and tremor; high doses carry rare risk of stroke. Green tea is generally well tolerated as a beverage but concentrated extracts in high doses have rarely caused liver injury.

Bitter orange can raise blood pressure and heart rate, especially combined with caffeine, and rarely causes serious cardiovascular events. Black pepper is generally safe as a food spice.

Dandelion is well tolerated short-term but may irritate kidneys with long-term use. Hordenine has very limited human safety data and acts as a stimulant.

Juniper berry may irritate kidneys and is unsafe in pregnancy. Lesser periwinkle is considered unsafe due to toxic alkaloids and is contraindicated in pregnancy and breastfeeding.

Red raspberry leaf is generally well tolerated but safety in breastfeeding is not confirmed. Pregnancy safety varies by ingredient: vitamin B6 is likely safe but possibly unsafe at high doses; caffeine is possibly safe but possibly unsafe; bitter orange and juniper are unsafe; hordenine, 7-keto, and periwinkle lack pregnancy data or are unsafe.

Side effects, ingredient by ingredient Vitamin B6

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 12 of the 13 matched ingredients can interact with medications — Red Raspberry, Periwinkle, Dandelion, Juniper, Lovage, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,496 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor before using Atro-phex if you take any of the following: monoamine oxidase inhibitors (MAOIs) — serious blood pressure risk; nadolol or other beta-blockers — reduced effectiveness; midazolam or other sedatives — increased levels; ephedrine or other stimulants — dangerous cardiovascular effects; seizure medications (phenytoin, phenobarbital, felbamate, ethosuximide, valproate, carbamazepine); blood thinners or antiplatelet drugs (warfarin, clopidogrel); blood pressure medications; heart rhythm drugs (amiodarone, QT-prolonging agents); antidiabetes drugs or insulin; cholesterol medications (atorvastatin); rifampin, nevirapine, or other antibiotics; lithium; and clozapine or other antipsychotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Atro-phex is a stimulant-heavy weight and energy product with significant medication interaction potential — especially if you take blood pressure drugs, seizure medications, blood thinners, or antidepressants. People with heart conditions, high blood pressure, or anxiety should talk with their pharmacist or doctor before using it.

The evidence for its effectiveness is limited, and several ingredients carry real risks at higher doses. This is one to check against your exact medications before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 15 of 24 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Atro-phex, straight from the product label.

Brand BSN
Barcode (UPC) 834266001088
Net contents 98 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 2079
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Atro-phex by BSN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
98
UPC/BARCODE
834266001088
IngredientAmount% DV
Vitamin B66 mg300%
Vitamin B60 NP--
Folate0 NP--
Folate100 mcg25%
Dandelion0 NP--
Hordenine HCl0 NP--
Yohimbine HCl0 NP--
7-Keto0 NP--
Juniper Berry Extract0 NP--
DL-Phenylalanine0 NP--
Beta-Phenylethylamine HCl0 NP--
ATRO-PHEX - EXTREME ENERGY & WEIGHT MANAGEMENT TECHNOLOGY680 mg--
Adipose Atrophy & Energy Stimulation Composite0 NP--
Methylxanthine0 NP--
N-Acetyl-l-Tyrosine-ethyl ester monohydrate0 NP--
i-FAS500 NP--
Green Tea0 NP--
Tuber Fleeceflower0 NP--
Chinese Mistletoe0 NP--
Bitter Orange 99% Naringin0 NP--
Advantra Z0 NP--
Bioperine0 NP--
Razberi-K0 NP--
Mood & Mental Performance Optimizers0 NP--
lesser Periwinkle0 NP--
Aqua-Retic Complex0 NP--
Lovage0 NP--
Insulin Support & Weight Management Matrix0 NP--
Cinnulin PF0 NP--
Pro-Thyroid Amplifiers0 NP--
Dicana0 NP--

Other ingredients: Magnesium Stearate, FD&C Blue# 1, FD&C Red# 40, Titanium Dioxide, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

ACCELERATED RESULTS SERVING*: 2 capsules, twice daily - everyday.

DYNAMIC RESULTS SERVING*: 3 capsules, twice daily- everyday.

EXAMPLE OF ATRO-PHEX(R) SERVING PROTOCOLS: These recommendations are only intended for individuals who have fully assessed their tolerance levels and can manage one of the below mentioned serving protocols. For a detailed description of product usage refer to the back panel.

EXTREME RESULTS SERVING*: 4 capsules, twice daily - everyday.

NOVICE RESULTS SERVING*: 1 capsule, twice daily - everyday.

RECOMMENDED USE: As a dietary supplement, begin by consuming 1 capsule of ATRO-PHEX(R) on an empty stomach 30-45 minutes before your first meal or protein shake. Wait approximately 4-5 hours, and if suitable, consume a second capsule (on an empty stomach 30-45 minutes before a meal or protein shake) and assesss your tolerance again. If appropriate (which can be determined by assesssing your tolerance level from the previous servings), repeat this procedure on the following day but increase each serving by 1 capsule. Continue to repeat this procedure each day until you have reached your individual tolerance level or you have reached the maximum of 4 capsules per serving, two times daily, whichever comes first. DO NOT exceed recommended use. For those individuals with a sensitive stomach, try the previously mentioned protocol with food or after a meal instead of on an empty stomach.

Precautions

Keep out of reach of children and pets and others for whom use of this product is not strictly intended.

DO NOT use and consult with a physician if you are pregnant, nursing, contemplating pregnancy, prone to dehydration, exposed to excessive heat or have an allergy to iodine.

ALLERGY WARNING: Manufactured on equipment, which processes products containing milk, soybeans, shellfish, fish, and wheat.

PHENYLKETONURICS: CONTAINS PHENYLALANINE

Before consuming ATRO-PHEX(R) seek advice from a physician if you are unaware of your current health condition or planning any medical procedure. This product contains caffeine, yohimbine, and synephrine. DO NOT consume synephrine or yohimbine from other sources, including but not limited to, other dietary supplements, medications, or products, which may also contain phenylephrine.

Discontinue 2 weeks prior to surgery.

CAUTION - READ ENTIRE LABEL BEFORE CONSUMING! ATRO-PHEX(R) is an extremely powerful dietary supplement strictly intended for use by healhty adults 18-50 years of age. PRACTICE CAUTION when using ATRO-PHEX(R) in direct combination with any other caffeine - or stimulant - containing products. If you are sensitive to caffeine or stimulants, begin with 1 capsule until your tolerance has been fully assesssed. DO NOT exceed 8 capsules within a 24 hour period. DO NO take within 4 hours of bedtime. DO NOT use if you are prone to dehydration or in an environment with excessive heat. When using ATRO-PHEX(R) consume a minimum of 120 ounces of water daily in conjunction with a healthy diet and regular exercise. Use only as directed.

Consume a minimum of 120 ounces of water daily in conjunction with a healthy diet and regular exercise. After 8 weeks of continuous use, discontinue for at least 1 week.

Discontinue use and call a physician immediately if you experience chest pain, tremors, dizziness, severe headaches, nausea, an irregular heartbeat, or shortness of breath.

DO NOT use ATRO-PHEX(R) if you have any pre-existing medical condition including but not limited to: high or low blood pressure, stroke, cardiac arrhythmia, heart liver, kidney, or thyroid disease, recurrent headaches, anxiety, depression, seizure disorder, psychiatric or epileptic disorders, diabetes, pernicious anemia, difficulty urinating, enlarged prostate or glaucoma, or if you are taking an MAO inhibitor, anti-depressants, aspirin, non-steroidal anti-inflammatory drugs or products containing phenylephrine, ephedrine, pseudoephedrine, or other medications or over the counter drugs containing stimulants, or any other form of medication.

NOTE: Always read all product labels prior to stacking any supplements together.

Too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

Use only as directed.

WARNING: Not intended for use by persons under age 18. Do not exceed recommended does. ATRO-PHEX(R) is strictly intended for use by healthy adults 18-50 years of age.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool dry place away from direct sunlight.

Formula

DESIGNED FOR: Healthy adults 18-50 years of age seeking to: manage unwanted body weight, increase energy, enhance mental focus, mood and well-being.*

General Statements

CORE SERIES

ENERGY & WEIGHT MANAGEMENT MATRIX*

FOUNDATION

MADE IN USA.

Peel Back

This product contains ingredients of international and domestic origin.

WEIGHT MANAGEMENT* - PHYSICAL ENERGY* -FOCUS* -WELL-BEING*

General

V.1.108.0310US

Brand IP Statement(s)

7-Keto(R) is a registered trademark of the Humanetics Corporation. Dicana(TM) is a patent pending compound and trademark of Thermolife International LLC. Cinnulin PF(R) is a registered trademark of Integrity Nutraceuticals International. Razberi-K(TM) and i-FAS50(TM) are trademarks of Integrity Nutraceuticals International. Advantra Z(R) - is a registered trademark of Nutratech, Inc./ Zhishin, LLC licensor of U.S. and Canadian Patents. Bioperine(R) - is a registered trademark of the Sabinsa Corporation.

ATRO-PHEX(R) PRODUCT HIGHLIGHTS: ATRO-PHEX(R) is designed to support: -Weight Management* -Metabolic Rate* -Focus and Well-Being* -Removal of Temporary Excess Water* -Thermogenic Fat Burning -Thyroid and Insulin Function already in the normal range

ATRO-PHEX(R) supports the following segments of the BSN SUPPLEMENT PYRAMID(TM): Weight Management & Performance Support.*

FINISH FIRST.(R)

Individual results may vary. ATRO-PHEX(R) should be used in conjunction with a well balanced weight management plan consisting of a healthy calorie controlled diet and regular exercise.

RECOMMENDED ATRO-PHEX(R) STACK FOR MEN: SYNTHA-6(TM), NITRIX(R), N.O.-XPLODE(TM), CELLMASS(R), VOULUMAIZE(R) and AXIS-HT(TM) for maximum physique and performance support.*

RECOMMENDED ATRO-PHEX(R) STACK FOR WOMEN: CHEATERS RELIEF(TM), LEAN DESSERT PROTEIN(TM), NITRIX(R), and N.O. -XPLODE(TM) for maximum physique and performance support.*

WIN THE BATTLE FOR DEFINITION(TM) *

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Atro-phex by BSN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Atro-phex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Atro-phex by BSN

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container98 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
6 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folate

100 mcg per serving Form: Folic Acid

ATRO-PHEX - EXTREME ENERGY & WEIGHT MANAGEMENT TECHNOLOGY

680 mg per serving
  • › Adipose Atrophy & Energy Stimulation Composite
  • › Mood & Mental Performance Optimizers
  • › Aqua-Retic Complex
  • › Insulin Support & Weight Management Matrix
  • › Pro-Thyroid Amplifiers

Other (inactive) ingredients: Magnesium Stearate, FD&C Blue# 1, FD&C Red# 40, Titanium Dioxide, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Atro-phex by BSN Drug Interactions

Want to check YOUR meds against Atro-phex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,495Drugs
23 Major 1,467 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210

Individual Drug Interactions

The ingredients in Atro-phex interact with 1,495 drugs. Click any drug to see the details.

1 of the 7 ingredients in Atro-phex interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in Atro-phex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Atro-phex, from the product label.

BSN

See all BSN products
Web Address
www.BSNonline.net
Pharmacist Counseling Corner

Atro-phex by BSN: Common Questions

Does Atro-phex by BSN interact with any medications?
Yes. Based on its ingredients, Atro-phex has a known interaction with 1,495 medications, including 23 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Atro-phex contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Several ingredients in Atro-phex are unsafe or have insufficient safety data in pregnancy. Hordenine, juniper berry, and lesser periwinkle should be avoided. Bitter orange is possibly unsafe. Talk with your doctor before using any weight-loss or stimulant supplement during pregnancy — the safest choice is to wait.
What does the caffeine in this do?
Caffeine is a stimulant that boosts alertness and mental energy, and it's been shown to improve athletic performance. In this product it works together with other stimulants like hordenine and bitter orange to provide an energy boost. Moderate amounts are generally tolerated, but high intakes can cause jitteriness, insomnia, and headache.
Why is there so much caffeine and stimulant stuff in here?
This product is designed for energy and weight management. The combination of caffeine, green tea, bitter orange, and hordenine all have stimulant properties that may increase alertness and metabolism. However, that also makes it a high-risk product if you're sensitive to stimulants or take certain medications.
Is it safe to use long-term?
Long-term safety is not well established for most ingredients in this product. Vitamin B6 can damage nerves with very high cumulative doses; bitter orange and hordenine carry cardiovascular risks with long-term use; and high-dose caffeine can lead to dependence and sleep problems. This is better suited for short-term use — talk to your doctor about duration.
What's Bioperine doing in here?
Bioperine is black pepper extract (piperine). It's included because it enhances absorption of other supplements — but it also increases blood levels of several medications, which is a reason to check with your pharmacist if you're on prescription drugs.
Will this help me lose weight?
The product is marketed for weight management, but we don't have solid evidence that it works. The stimulants may slightly boost metabolism and suppress appetite temporarily, but long-term weight loss hasn't been proven in our data. A pharmacist or doctor can discuss whether it's right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Atro-phex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Atro-phex label
Go deeper

The Full Monographs Behind Atro-phex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

Atro-phex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 691 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
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Red Raspberry 8 references
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  2. Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
  3. Simpson M, Parsons M, Greenwood J, Wade K. Raspberry leaf in pregnancy: its safety and efficacy in labor. J Midwifery Womens Health 2001;46:51-9.. PubMed
  4. Mullen W, McGinn J, Lean ME, et al. Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 2002;50:5191-6.. PubMed
  5. Sherson, D., Andersen, B., Hansen, I., and Kjoller, H. Occupational asthma due to freeze-dried raspberry. Ann Allergy Asthma Immunol. 2003;90(6):660-663. PubMed
  6. Cheang KI, Nguyen TT, Karjane NW, Salley KE. Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus. Obstet Gynecol. 2016;128(6):1421-4. PubMed
  7. Dudzinska D, Bednarska K, Boncler M, Luzak B, Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433-9.
  8. Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed

See these in context on the Red Raspberry monograph →

Periwinkle 5 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  5. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Periwinkle monograph →

Lovage 10 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  7. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  8. Ashwood-Smith MJ, Ceska O, Yeoman A, et al. Photosensitivity from harvesting lovage (Levisticum officinale). Contact Dermatitis 1992;26(5):356-357.
  9. Martynyuk L, Martynyuk L, Ruzhitska O, Martynyuk O. Effect of the herbal combination Canephron N on diabetic nephropathy in patients with diabetes mellitus: results of a comparative cohort study. J Altern Complement Med. 2014;20(6):472-478. PubMed
  10. Lapeere H, Boone B, Verhaeghe E, Ongenae K, Lambert J. Contact dermatitis caused by lovage (Levisticum officinalis) essential oil. Contact Dermatitis 2013;69(3):181-2.

See these in context on the Lovage monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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