Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Natural Astaxanthin Extract Ingredients & Drug Interactions

by CATALO

Natural Astaxanthin Extract label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Astaxanthin Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Astaxanthin Extract is a dietary supplement by CATALO with 5 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 832 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Astaxanthin, Natural, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Natural Astaxanthin Extract by CATALO

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Astaxanthin Extract by CATALO — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Astaxanthin Extract by CATALO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “AstaReal” is listed as a grouped ingredient — the label gives one combined amount (80 mg) without saying how much of each component you get.

This product has 2 active ingredients: sodium and natural astaxanthin (provided as AstaReal, a branded extract). Sodium is an electrolyte essential for nerve and muscle function, though the product's sodium dose is the main interaction concern.

Astaxanthin is a carotenoid antioxidant derived from algae. The softgel also contains extra virgin olive oil, gelatin, and glycerin as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: heart and cardiovascular health, skin health and aging.
  • We looked for evidence on: Congestive heart failure, Heart failure, Hyperlipidemia, Hypertension, Metabolic syndrome, Aging skin — and 4 related terms.
  • The closest evidence on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Aging skin (Natural Medicines).
  • Also on file: Astaxanthin is rated "Insufficient Reliable Evidence To Rate" for Heart failure, Exercise-induced muscle soreness, Hyperlipidemia, Hypertension, and more.

The evidence for this product's active ingredients is mixed and limited. Sodium's effectiveness ratings in the data we hold apply to medical uses (cystic fibrosis, amphotericin B side effects, bipolar disorder, and heart failure) rather than general supplement use, and most lack strong evidence.

Astaxanthin has not been reliably established to work for the conditions we checked—age-related cognitive decline, macular degeneration, aging skin, Alzheimer disease, athletic performance, and carpal tunnel syndrome—all show insufficient evidence in our data. If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Sodium Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is generally well tolerated at normal dietary amounts, but the safety notes emphasize caution: too much is linked to high blood pressure and heart strain. Avoid sodium supplements or very high intakes without medical advice.

Rare but serious effects of excess sodium include worsened cardiovascular disease, high blood pressure, and kidney disease. Astaxanthin seems to be well tolerated in studies, though long-term safety data are limited.

Most common side effects in trials were abdominal pain, diarrhea, and red-colored stool; at higher doses, severe stomach pain has been reported in a small number of trial participants.

Side effects, ingredient by ingredient Sodium Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Astaxanthin, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 833 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you're on blood pressure medications (antihypertensives), lithium, corticosteroids, didanosine, sodium phosphate bowel-prep products, tolvaptan, or any other sodium-containing drugs—sodium can affect how these work or raise your sodium levels dangerously. Also flag any medications processed by your liver through the CYP3A4 or CYP2B6 systems, since astaxanthin may theoretically slow their clearance, though this hasn't been confirmed in people yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may not be the right fit if you take blood pressure medications, lithium, corticosteroids, or other sodium-sensitive drugs, or if you're managing high blood pressure or heart disease. The astaxanthin ingredient lacks established effectiveness for most marketed uses.

Before you start, run your medications through the interaction checker on this page and discuss the product with your own doctor or pharmacist, especially if sodium intake is a concern for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Astaxanthin Extract, straight from the product label.

Brand CATALO
Net contents 60 Softgel(s); 36 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303108
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Astaxanthin Extract by CATALO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Sodium1 mg--
Carbohydrates0.4 Gram(s)--
Energy8 Kcal--
Total Fat0.8 Gram(s)--
Saturated Fat0.1 Gram(s)--
Trans Fat0 Gram(s)--
Protein0 Gram(s)--
Sugars0 Gram(s)--
Astaxanthin, Natural8 mg--
AstaReal80 mg--

Other ingredients: Extra Virgin Olive Oil, Gelatin, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Powerful antioxidant Healthy heart & skin For heart & cardiovascular health Skin elasticity clinically proven

Main functions: Superb antioxidant for supporting cardiovascular health Superior natural anti-aging regimen to promote healthy body cells Maintain youthful appearance and prevent premature signs of aging

Suitable for: Concerned about cardiovascular health, desire for young and beautiful skin, frequent computer users, always feel tired or lack of energy

Multi-functional superb antioxidant Superior anti-aging regimen Maintain heart & cardiovascular health

High bioavailability Super high potency

Made in USA Manufactured by a cGMP certified facility

cGMP Current Good Manufacturing Practices

FDA Statement of Identity

Dietary Supplement

Formula

Catalo Extra Astaxanthin Extract is made from unpolluted freshwater microalgae to protect cells from oxidative damages. Being the most powerful antioxidant agent among anti-aging molecules (Nishida, Y., et al. 2007, Carotenoid Science, Vol.11.pp.16-20), Astaxanthin fights against free radicals both in the inner and outer sides of cell membranes, whereas most antioxidants work only in ether one of the sides. Astaxanthin is clinically proven to improve blood flow by removing wastes and increasing the flexibility or blood vessels (Miyawaki, H., et al. 2008, J.Clin Biochem Nutrition, Vol. 43(2), pp.66-74). It is also clinically proven to reduce age spot areas and skin wrinkles visibly (Tominga, K., et al. 2012, Acta Biochemica Polonica, Vol.59(1), pp.43-47) while improving skin elasticity and moisture (Yamashita, E. 2006, Cartenoid Science, Vol. 10, pp.91-95). Astaxanthin is an excellent anti-aging and cardiovascular supplement you can trust.

Suggested/Recommended/Usage/Directions

Serving directions For adults, take 2 softgels daily. Take after meal

Storage

Storage Keep in a dry and cool place. Avoid direct sunlight

Brand IP Statement(s)

AstaREAL is a trademark of Fuji Chemical Industry Co., Ltd.

Seals/Symbols

cGMP Current Good Manufacturing Practices

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Astaxanthin Extract by CATALO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Astaxanthin Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Astaxanthin Extract by CATALO

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
1 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Carbohydrates

0.4 Gram(s) per serving

Energy

8 Kcal per serving

Protein

0 Gram(s) per serving

AstaReal

80 mg per serving Form: Algae Extract

Other (inactive) ingredients: Extra Virgin Olive Oil, Gelatin, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Astaxanthin Extract by CATALO Drug Interactions

Want to check YOUR meds against Natural Astaxanthin Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
832Drugs
832 Moderate

Ingredients driving the most interactions

Astaxanthin, Natural 671
Sodium 205

Individual Drug Interactions

The ingredients in Natural Astaxanthin Extract interact with 832 drugs. Click any drug to see the details.

2 of the 5 ingredients in Natural Astaxanthin Extract interact with drugs. Each result below shows which ingredient is responsible. Astaxanthin, Natural Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Astaxanthin Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Astaxanthin, Natural2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin, Natural full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Astaxanthin Extract, from the product label.

CATALO

See all CATALO products
Name
CATALO Natural Health Foods
Street Address
5/F, Suite C-D, 15 Cheung Shun St.
City
Hong Kong
Phone Number
(852) 3556 8686
Web Address
CATALO.com
Pharmacist Counseling Corner

Natural Astaxanthin Extract by CATALO: Common Questions

Does Natural Astaxanthin Extract by CATALO interact with any medications?
Yes. Based on its ingredients, Natural Astaxanthin Extract has a known interaction with 832 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Astaxanthin Extract contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy or while breastfeeding?
The data on sodium shows mixed safety ratings for pregnancy and lactation. Astaxanthin has insufficient data and the safety notes advise against it during pregnancy and breastfeeding. Because the product contains both ingredients, there isn't enough data to know it's safe either way. Talk with your doctor or pharmacist for personalized advice before taking it if you're pregnant or nursing.
What is astaxanthin, and why is it in this product?
Astaxanthin is a red carotenoid antioxidant naturally derived from algae (in this case, provided as AstaReal, a branded extract). It's marketed for a range of health claims, but the evidence we hold is insufficient to confirm it works for aging skin, cognitive decline, eye health, or the other conditions it's often promoted for.
What are the most common side effects?
Astaxanthin has caused abdominal pain, diarrhea, and red-colored stool in trial participants. At higher doses, severe stomach pain has been reported in a few people. Sodium at normal dietary levels is generally well tolerated, but excess sodium carries a risk of high blood pressure and heart strain.
Does this product have fillers or anything else besides the active ingredients?
Yes, the softgel contains three inactive ingredients: extra virgin olive oil, gelatin, and glycerin, which are used to hold and deliver the active ingredients.
Why does a small supplement have so many drug interactions?
The bulk of the 833 interactions come from sodium—one of the two active ingredients. Sodium is involved in so many cellular and organ processes that it interacts with a wide range of medications, from blood pressure drugs to lithium to various others. That's why it's important to check your specific medications before starting.
Can I take this if I'm on a blood pressure medication?
That depends on your specific medication and how your blood pressure is controlled. Sodium can reduce how well some blood pressure drugs work and may increase sodium levels in your blood. Check with your own doctor or pharmacist—they know your full medication list and can tell you whether this product is safe to add.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Astaxanthin Extract label
Go deeper

The Full Monographs Behind Natural Astaxanthin Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Natural Astaxanthin Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 41 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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