Armodafinil
29 interactions 4 explained in plain English
Also sold as:
Nuvigil
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Olodaterol Oral Inhalation
Nifedipine
Medroxyprogesterone Injection
Levonorgestrel
Estradiol Transdermal Patch
Major
Armodafinil Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Armodafinil Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Armodafinil Atogepant Qulipta Reduced atogepant exposure Details Armodafinil Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Armodafinil Amlodipine Amvaz® Reduced amLODIPine exposure Details Armodafinil Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Armodafinil Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Armodafinil Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Armodafinil Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Armodafinil Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Armodafinil Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Armodafinil Lumateperone Caplyta Reduced lumateperone exposure Details Armodafinil Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Armodafinil Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Armodafinil Nifedipine Adalat® Reduced NIFEdipine exposure Details Armodafinil Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... DetailsModerate
Armodafinil Omeprazole Gastrobim Explained Increased omeprazole exposure Details Armodafinil Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Armodafinil Cyclosporine Injection Atopica Decreased cycloSPORINE effectiveness Details Armodafinil Cyclosporine Ophthalmic Cequa Decreased cycloSPORINE effectiveness Details Armodafinil Diazepam Nasal Spray Valtoco Increased diazepam exposure Details Armodafinil Diazepam Rectal Diastat Increased diazepam exposure Details Armodafinil Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Armodafinil Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Armodafinil Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Armodafinil Midazolam Nasal Spray Nayzilam Decreased midazolam effectiveness Details Armodafinil Midazolam Injection Nayzilam Decreased midazolam effectiveness Details Armodafinil Nimodipine Nimotop Reduced nimodipine plasma concentrations and lack of nimodipine efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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