Armodafinil
29 interactions 4 explained in plain English
Also sold as:
Nuvigil
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Olodaterol Oral Inhalation
Nifedipine
Medroxyprogesterone Injection
Levonorgestrel
Estradiol Transdermal Patch
Moderate
Armodafinil Omeprazole Gastrobim Explained Increased omeprazole exposure Details Armodafinil Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Armodafinil Cyclosporine Injection Atopica Decreased cycloSPORINE effectiveness Details Armodafinil Cyclosporine Ophthalmic Cequa Decreased cycloSPORINE effectiveness Details Armodafinil Diazepam Nasal Spray Valtoco Increased diazepam exposure Details Armodafinil Diazepam Rectal Diastat Increased diazepam exposure Details Armodafinil Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Armodafinil Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Armodafinil Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Armodafinil Midazolam Nasal Spray Nayzilam Decreased midazolam effectiveness Details Armodafinil Midazolam Injection Nayzilam Decreased midazolam effectiveness Details Armodafinil Nimodipine Nimotop Reduced nimodipine plasma concentrations and lack of nimodipine efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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