Bendroflumethiazide

52 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Albuterol Oral Inhalation Digoxin Arsenic Trioxide Morphine Injection Bromfenac Ophthalmic

36 Major 16 Moderate

All (52) Major (36) Moderate (16)

Major

Bendroflumethiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Bendroflumethiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Bendroflumethiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Bendroflumethiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Bendroflumethiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Bendroflumethiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Bendroflumethiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Bendroflumethiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Bendroflumethiazide Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Bendroflumethiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Bendroflumethiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Bendroflumethiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Lithium Carbonate Lithobid Lithium toxicity Details Bendroflumethiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Bendroflumethiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Bendroflumethiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Bendroflumethiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Bendroflumethiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Bendroflumethiazide Benazepril Lotensin Reduction of blood pressure Details Bendroflumethiazide Calcitriol Rocaltrol Increased serum calcium levels resulting in hypercalcemia Details

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