Macitentan
58 interactions 249 cited referencesMacitentan is used to manage the symptoms of pulmonary arterial hypertension (PAH; high blood pressure in the vessels that carry blood to the lungs). Macitentan is in a class of medications called endothelin receptor antagonists. It works by stopping the action of endothelin, a natural substance that causes blood vesse… Read the full Macitentan drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Contraindicated
Macitentan Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Macitentan Sparsentan Filspari An increased risk of hypotension, syncope, hyperkalemia, and changes in renal function, reduced macitentan exposure and reduced ef... DetailsMajor
Macitentan Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Macitentan Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Macitentan Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Macitentan Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Macitentan Ketoconazole Topical Extina® Foam Increased macitentan exposure Details Macitentan Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Macitentan Amiodarone Nexterone Increased macitentan exposure Details Macitentan Apalutamide Erleada Reduced macitentan exposure Details Macitentan Avacopan Tavneos Increased CYP3A4 substrate exposure Details Macitentan Boceprevir Increased macitentan exposure Details Macitentan Carbamazepine Carbatrol Reduced macitentan exposure Details Macitentan Ceritinib Zykadia Increased macitentan exposure Details Macitentan Clarithromycin Biaxin Increased macitentan exposure Details Macitentan Cobicistat Tybost Increased macitentan exposure Details Macitentan Conivaptan Vaprisol Increased CYP3A substrate exposure Details Macitentan Deutivacaftor Increased CYP2C9 substrate exposure Details Macitentan Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Macitentan Enzalutamide Xtandi Reduced macitentan exposure Details Macitentan Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Macitentan Fluconazole Diflucan Increased macitentan exposure Details Macitentan Fosphenytoin Cerebyx Reduced macitentan exposure Details Macitentan Idelalisib Zydelig Increased macitentan exposure Details Macitentan Indinavir Increased macitentan exposure Details Macitentan Itraconazole Sporanox Increased macitentan exposure Details Macitentan Ivacaftor Kalydeco Reduced macitentan exposure Details Macitentan Ivosidenib Tibsovo Reduced macitentan exposure Details Macitentan Ketoconazole Extina Increased macitentan exposure Details Macitentan Letermovir Prevymis Increased CYP3A substrate exposure Details Macitentan Lonafarnib Zokinvy Increased macitentan exposure Details Macitentan Lumacaftor Reduced macitentan exposure Details Macitentan Mifepristone Korlym Increased macitentan exposure Details Macitentan Mitotane Lysodren Reduced macitentan exposure Details Macitentan Nefazodone Increased macitentan exposure Details Macitentan Nelfinavir Viracept Increased macitentan exposure Details Macitentan Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Macitentan Paritaprevir Increased macitentan exposure Details Macitentan Phenytoin Dilantin Reduced macitentan exposure Details Macitentan Posaconazole Noxafil Increased macitentan exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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