Venlafaxine
130 interactions 6 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Linezolid Injection
Metoclopramide Nasal Spray
Metoclopramide Injection
Ketoconazole Topical
Betrixaban
Hydroxychloroquine
Contraindicated
Venlafaxine Ketoconazole Topical Extina® Foam Increased venlafaxine exposure and its active metabolite and an increased risk for QT interval prolongation Details Venlafaxine Linezolid Injection Zyvox An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Venlafaxine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Venlafaxine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Venlafaxine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Venlafaxine Amitriptyline Elavil Explained Increased CYP2D6 substrate exposure, increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Venlafaxine Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Venlafaxine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of serotonin syndrome Details Venlafaxine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Venlafaxine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Venlafaxine Amoxicillin Amoxi Drop An increased risk of serotonin syndrome Details Venlafaxine Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Venlafaxine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Venlafaxine Aripiprazole Injection Abilify Increased CYP2D6 substrate exposure and an increased risk of QT interval prolongation Details Venlafaxine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Venlafaxine Asenapine Transdermal Patch Secuado Increased venlafaxine exposure, an increased asenapine exposure and an increased risk of QT interval prolongation Details Venlafaxine Aspirin Acuprin® An increased risk of bleeding Details Venlafaxine Aspirin Rectal Aspirin An increased risk of bleeding Details Venlafaxine Azathioprine Azasan An increased risk of hepatotoxicity Details Venlafaxine Azithromycin AzaSite An increased risk of QT interval prolongation Details Venlafaxine Betrixaban Bevyxxa® An increased risk of bleeding Details Venlafaxine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Venlafaxine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Venlafaxine Anagrelide Agrylin An increased risk of bleeding and an increased risk of QT interval prolongation Details Venlafaxine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Venlafaxine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Venlafaxine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Venlafaxine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Venlafaxine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Venlafaxine Clopidogrel Plavix An increased risk of bleeding Details Venlafaxine Cyclosporine Injection Atopica Increased venlafaxine exposure and its active metabolite and risk of venlafaxine-associated toxicity Details Venlafaxine Cyclosporine Ophthalmic Cequa Increased venlafaxine exposure and its active metabolite and risk of venlafaxine-associated toxicity Details Venlafaxine Dabigatran Pradaxa® An increased risk of bleeding Details Venlafaxine Dabigatran Etexilate An increased risk of bleeding Details Venlafaxine Dalteparin Injection Fragmin An increased risk of bleeding Details Venlafaxine Dasatinib Phyrago An increased risk of QT interval prolongation Details Venlafaxine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Venlafaxine Deutetrabenazine Austedo Increased deutetrabenazine exposure Details Venlafaxine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Venlafaxine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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