Drug & supplement interaction

Puravive + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine

Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine brand names: Robitussin Cold, Suphedrine Cold/Cough, Severe Cold.

Minor Interaction
Medically reviewed by · Updated February 2024
The bottom line Minor

Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine falls into 3 drug categories that Puravive can interact with; the most serious is rated minor. Puravive contains Panax ginseng. Some research suggests that Panax ginseng might slow down the activity of an enzyme called CYP2D6 by about 6%.

Read the full interaction report
SeverityMinor
LikelihoodPossible
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Puravive and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Puravive interacts with whole categories of medication. Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine falls into 3 of those categories, so it can interact with Puravive in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Minor).

Minor

Cytochrome P450 2D6 (Cyp2D6) Substrates

1 of 3

Why this applies to Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine

Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine falls under Cytochrome P450 2D6 (Cyp2D6) Substrates — the group Puravive interacts with.

Puravive contains Panax ginseng. Some research suggests that Panax ginseng might slow down the activity of an enzyme called CYP2D6 by about 6%. This enzyme plays a role in breaking down drugs in our system. One study (https://pubmed.ncbi.nlm.nih.gov/32557706/) found that Panax ginseng slows down the breakdown of dextromethorphan, a drug that is processed by CYP2D6, but only to a small extent. It is important to note that not all studies agree on these effects, and some suggest that Panax ginseng might not have a significant impact on CYP2D6 at all. Nevertheless, it's important to be cautious if you're taking medications that are processed by CYP2D6 and consider discussing it with your healthcare provider.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Out of all the ingredients in your cold and cough combo, the one that touches this interaction is dextromethorphan, the cough suppressant. It's cleared by a liver enzyme called CYP2D6. Puravive contains Panax ginseng, which may slow that enzyme down just a little (around 6% in one study), and not every study even agrees it does anything at all.

In plain terms, if dextromethorphan clears a touch slower, its levels could nudge up slightly, which might mean a bit more drowsiness or dizziness. Honestly, this is rated minor, and a 6% change is small. The acetaminophen, guaifenesin, and pseudoephedrine aren't really part of this. Still, if you feel unusually groggy or off, check in with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Cytochrome P450 3A4 (Cyp3A4) Substrates

2 of 3

Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under Cytochrome P450 3A4 (Cyp3A4) Substrates.

Puravive contains Panax ginseng. Panax ginseng has the potential to affect the breakdown of drugs that are metabolized by an enzyme called CYP3A4. One example of such a drug is imatinib. There was a case where imatinib was thought to have caused liver damage, and it was believed that this might have been due to Panax ginseng inhibiting CYP3A4, which is involved in imatinib's metabolism (https://pubmed.ncbi.nlm.nih.gov/20332334/). On the other hand, Panax ginseng has been found to increase the breakdown of another drug called midazolam, which is also metabolized by CYP3A4 (https://pubmed.ncbi.nlm.nih.gov/21646440/), suggesting Panax ginseng induces CYP3A4 in some cases (i.e., makes more potent). Given these contradictory findings, it is important to use Panax ginseng cautiously if you are taking medications that are metabolized by CYP3A4, as the interaction between Panax ginseng and these drugs is not fully understood.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest version: this is a very minor, mostly theoretical concern. Puravive contains Panax ginseng, which can nudge a liver enzyme called CYP3A4 in either direction (sometimes speeding it up, sometimes slowing it down). Out of your cold combo, dextromethorphan (the cough suppressant) is the one partly handled by that enzyme. If anything shifted, you might notice slightly more drowsiness or dizziness, or a touch less cough relief.

In real life, this is unlikely to cause a noticeable problem at normal doses, and the evidence here is weak and inconsistent. Acetaminophen, guaifenesin, and pseudoephedrine aren't meaningfully affected. Still, since Puravive's effects aren't well studied, it's worth a quick chat with your pharmacist before pairing them, especially if you take anything daily.

Contact Dr. Brian directly if you have additional questions on this interaction
Minor

Stimulant Drugs

3 of 3

Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under Stimulant Drugs.

Puravive contains Panax ginseng. Panax ginseng has demonstrated stimulant effects in some studies, which could potentially heighten the effects of other stimulant drugs (source: https://pubmed.ncbi.nlm.nih.gov/8879982/). It is unlikely this would result in a significant risk of side effects, but it is important to be aware of.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the piece that matters for this cold and cough combo: it contains pseudoephedrine, which is itself a stimulant decongestant. Puravive includes Panax ginseng, and ginseng has shown mild stimulant-like effects in some studies. Stacking two things that can rev you up could, in theory, add together a little. That might mean more jitteriness, a faster or pounding heartbeat, trouble sleeping, or a slightly higher blood pressure.

That said, the evidence here is weak and this is rated a minor, unlikely interaction. For most healthy folks taking a short course for a cold, it probably won't cause real trouble. But if you have high blood pressure, heart issues, or feel wired, check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Puravive Also Interacts With Other Medications

Puravive has 357 moderate, 880 minor known drug interactions in our database — the Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine one above is among them. If you take anything else, check it against the full list below.

Moderate 357 Minor 880 No known interaction 1,593 (incl. Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Puravive

Covers the 2,830 medications we’ve checked against Puravive. Pick one to open its full report.

From our Q&A

Questions About Puravive or Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Puravive or Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine

This page covers Puravive only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine page lists 262 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Grapefruit (major).

By severity: 12 major · 207 moderate · 43 minor.

Open the Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction page

How much people look this up

Where Puravive and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Puravive
Top half

#569 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine
Top 5%

#129 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Puravive

What is Puravive?

Puravive
  • Weight management
  • Metabolism support
  • Energy levels
  • General wellness
  • Stress and brain health

Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no published, independent clinical research showing the product itself works for this purpose. Some individual ingredients have been studied in laboratory or small human studies, but those results do not prove the finished blend is safe or effective. Talk to a pharmacist or doctor before trying it, especially if you have health conditions or take medications.

Read the full Puravive monograph & all interactions
Keep checking

Other Drugs & Puravive

Browse every other medication we’ve checked against Puravive — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
357Moderate
880Minor
1,592No known interaction
357 Moderate 880 Minor 1,592 No interaction
Moderate

357 interactions

Showing 60 of 357 moderate interactions — see all 357 on the Puravive page.

Minor

880 interactions

Showing 60 of 880 minor interactions — see all 880 on the Puravive page.

No interaction 1,592 drugs checked — show the list

We also checked Puravive against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,592 medications checked with no known interaction — see the full Puravive list.

See the full Puravive interactions page
See every supplement checked against Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Puravive monograph › Uses, safety, and every drug interaction in one place Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine supplement interactions › Every supplement checked against Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Puravive and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine Together: Common Questions

Can you take Puravive with Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Puravive and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine?
Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine belongs to more than one drug category, and Puravive interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Puravive and Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.