Puravive - Aleve Cold and Sinus (Naproxen, Pseudoephedrine) Interaction
Herbal: Puravive
Drug: Naproxen, Pseudoephedrine
Brand names:
Aleve Cold and Sinus
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Feb 05, 2024
Interaction Details
Naproxen, Pseudoephedrine is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Puravive, a dietary supplement, contains several ingredients that may interact with anticoagulant drugs due to their potential mild anticoagulant effects. These ingredients include Kudzu, Panax ginseng, Phellodendron, and Propolis. Ginsenosides in Panax ginseng may decrease platelet aggregation in lab studies, but human studies have not confirmed this effect. Animal studies suggest low oral bioavailability of certain compounds in ginseng, which could explain differences between lab and human research. Propolis water extract and caffeic acid phenethyl ester, found in propolis, have also been shown to inhibit platelet aggregation in lab studies. Additionally, in an animal model, propolis taken with warfarin reduced the effectiveness of warfarin, suggesting a potential interaction with anticoagulant drugs. Lastly, Phellodendron contains berberine, which studies show may inhibit platelet aggregation.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Interaction Details
Naproxen, Pseudoephedrine is classified as belonging to the following category: Cytochrome P450 2C9 (Cyp2C9) Substrates
Puravive contains quercetin, which has been shown in studies to mildly inhibit the CYP2C9 metabolizing enzyme. This inhibition could potentially increase the risk of side effects from drugs. A small clinical trial with healthy volunteers found that taking 500 mg of quercetin twice daily for 10 days before using diclofenac, a drug metabolized by CYP2C9, increased diclofenac plasma levels by 75% and extended its half-life by 32.5% (source: https://pubmed.ncbi.nlm.nih.gov/29168292/). Combining quercetin with drugs metabolized by CYP2C9 could increase the risk of side effects, so caution is advised.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Interaction Details
Naproxen, Pseudoephedrine is classified as belonging to the following category: Stimulant Drugs
Puravive contains Panax ginseng. Panax ginseng has demonstrated stimulant effects in some studies, which could potentially heighten the effects of other stimulant drugs (source: https://pubmed.ncbi.nlm.nih.gov/8879982/). It is unlikely this would result in a significant risk of side effects, but it is important to be aware of.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Puravive Overview
Puravive is a dietary supplement formulated with a blend of natural ingredients purported to support various aspects of health, with a specific focus on targeting and optimizing brown adipose tissue (BAT) levels in the body (which may help increase the rate at which calories are 'burned'). Puravive is marketed with claims related to brain health, cholesterol levels, cardiovascular function, stress reduction, immunity, digestion, and blood sugar regulation. Puravive contains several herbal ingredients, including Luteolin, Kudzu Root Extract, Holy Basil, White Korean Ginseng, Propolis, Quercetin, and Oleuropein.
Puravive - More Interactions
Puravive interacts with 1207 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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