Medication interaction hub

What Supplements Interact with Naproxen, Pseudoephedrine?

Naproxen, Pseudoephedrine brand name: Aleve Cold and Sinus. Every interaction below applies to the brands too.

334 Interactions 11 Major 279 Moderate 44 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Naproxen, Pseudoephedrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Naproxen, Pseudoephedrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Aleve Cold and Sinus pairs naproxen, an anti-inflammatory painkiller, with pseudoephedrine, a decongestant that acts as a mild stimulant, and that combination is why its supplement list runs to 334 entries and deserves real vigilance. The two biggest themes mirror the two drugs. Over 200 of these ingredients can add to naproxen's effect on bleeding, and another 44 can pile stimulant effects on top of pseudoephedrine, raising blood pressure and heart strain. Beer and wine sit among the 11 major-rated entries because alcohol taken with an NSAID sharply raises the odds of stomach bleeding.

Ephedra is the stimulant standout to avoid outright, and a few other majors add kidney strain instead. Beyond those 11, the 279 moderate and 44 minor entries mostly involve milder bleeding risks, caffeine sources, or changes in how the body processes the drug. Learn the majors first, then check whatever you take daily against the full list.

— , Clinical Pharmacist · July 18, 2026

Major 11 Moderate 279 Minor 44 No known interaction 1,118

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Naproxen, Pseudoephedrine: Top Interactions at a Glance

The Naproxen, Pseudoephedrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 334 interacting ingredients — plus 1,118 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Naproxen, Pseudoephedrine Combinations Today

The Naproxen, Pseudoephedrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Unlikely Honey + Naproxen, Pseudoephedrinei

Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Caprylic Acid + Naproxen, Pseudoephedrinei

Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Read the full interaction Major Likelihood Probable Beer + Naproxen, Pseudoephedrinei

Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Read the full interaction Moderate Likelihood Probable Cocoa + Naproxen, Pseudoephedrinei

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Dandelion + Naproxen, Pseudoephedrinei

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Minor Likelihood Unlikely Pomegranate + Naproxen, Pseudoephedrinei

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.

Read the full interaction
The complete list

Every Supplement Checked Against Naproxen, Pseudoephedrine

All 1,452 ingredients in our database, ranked by severity — 334 with a Naproxen, Pseudoephedrine interaction on file and 1,118 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Naproxen, Pseudoephedrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Honey with Naproxen, Pseudoephedrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Honey + Naproxen, Pseudoephedrine answer

Can you take Caprylic Acid with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caprylic acid might increase plasma concentrations of NSAIDs.

Full Caprylic Acid + Naproxen, Pseudoephedrine answer

Can you take Beer with Naproxen, Pseudoephedrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use may increase the risk of gastrointestinal (GI) bleeding.

Full Beer + Naproxen, Pseudoephedrine answer

Can you take Cocoa with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Cocoa + Naproxen, Pseudoephedrine answer

Can you take Dandelion with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.

Full Dandelion + Naproxen, Pseudoephedrine answer

Can you take Rooibos with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP1A2 substrates may increase the effects of CYP1A2 substrates.

Full Rooibos + Naproxen, Pseudoephedrine answer

Can you take Rose Hip with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rose hip might reduce the effectiveness of anticoagulant or antiplatelet drugs.

Full Rose Hip + Naproxen, Pseudoephedrine answer

Can you take Rosemary with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Rosemary + Naproxen, Pseudoephedrine answer

Can you take Rue with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rue might increase the risk for phototoxicity when used with photosensitizing drugs.

Full Rue + Naproxen, Pseudoephedrine answer

Can you take Safflower with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. High doses of safflower oil might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Safflower + Naproxen, Pseudoephedrine answer

Can you take Sage with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.

Full Sage + Naproxen, Pseudoephedrine answer

Can you take Saw Palmetto with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Saw Palmetto + Naproxen, Pseudoephedrine answer

Can you take Schisandra with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.

Full Schisandra + Naproxen, Pseudoephedrine answer

Can you take Schizonepeta with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2.

Full Schizonepeta + Naproxen, Pseudoephedrine answer

Can you take Sea Buckthorn with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Sea Buckthorn + Naproxen, Pseudoephedrine answer

Can you take Securinega Suffruticosa with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Naproxen, Pseudoephedrine answer

Can you take Selenium with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Selenium + Naproxen, Pseudoephedrine answer

Can you take Serrapeptase with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleedi...

Full Serrapeptase + Naproxen, Pseudoephedrine answer

Can you take Sesame with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sesame might increase the levels and clinical effects of CYP2C9 substrates.

Full Sesame + Naproxen, Pseudoephedrine answer

Can you take Slippery Elm with Naproxen, Pseudoephedrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Naproxen, Pseudoephedrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Naproxen, Pseudoephedrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Naproxen, Pseudoephedrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Naproxen, Pseudoephedrine sits in 13 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Naproxen, Pseudoephedrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Naproxen, Pseudoephedrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Naproxen, Pseudoephedrine through this category.

Pseudoephedrine (Sudafed) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Naproxen, Pseudoephedrine through this category.

Related: does Naproxen, Pseudoephedrine deplete any nutrients?

Naproxen, Pseudoephedrine has 1 reported nutrient association in the research literature — see the Naproxen, Pseudoephedrine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Naproxen, Pseudoephedrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Naproxen, Pseudoephedrine.

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Pharmacist Counseling Corner

Naproxen, Pseudoephedrine & Supplements: Common Questions

What supplements interact with Naproxen, Pseudoephedrine?
In our interaction database, 334 supplement and herbal ingredients have an interaction with Naproxen, Pseudoephedrine on file — 11 rated major, 279 moderate, and 44 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Naproxen, Pseudoephedrine supplement interactions are the most serious?
The 11 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer, Danshen and Ephedra — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Naproxen, Pseudoephedrine?
That depends entirely on which supplement. The honest answer for Naproxen, Pseudoephedrine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Aleve Cold and Sinus have the same supplement interactions as Naproxen, Pseudoephedrine?
Yes — Aleve Cold and Sinus all contain Naproxen, Pseudoephedrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Naproxen, Pseudoephedrine deplete any vitamins or nutrients?
It might — Naproxen, Pseudoephedrine has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Naproxen, Pseudoephedrine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Naproxen, Pseudoephedrine and my other medications?
This page covers Naproxen, Pseudoephedrine against supplements and herbal ingredients. Checking Naproxen, Pseudoephedrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.