Herb & supplement monograph

Agaricus Mushroom Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Agaricus Mushroom interacts with medications. The heart of this page is the interaction list — every drug Agaricus Mushroom is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Agaricus Mushroom is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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On this page

Agaricus Mushroom Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Agaricus Mushroom drug interaction appears low for most people, with the main caution applying to those who take medicines for diabetes. None of the listed interactions are rated major, and every one traces back to a single moderate concern about blood sugar.

Interactions deserving the most attention

The combination that deserves the most attention is Agaricus mushroom with diabetes medications. In one small study, a few people with type 2 diabetes who were already stable on oral blood sugar medicines reported low blood sugar while taking an agaricus extract, compared with just one person taking placebo. Because blood sugar medicines work within a narrow margin, an added glucose-lowering effect could matter, even though the evidence so far is limited.

What the rest of the list means

Although the number of listed medications looks large, it does not mean each combination is proven harmful. Nearly all of these entries reflect the same theoretical possibility of an additive effect on blood sugar, supported mainly by one small study rather than strong human evidence. For people not taking diabetes medicines, no other documented concerns stand out.

Check your medications against Agaricus Mushroom

Based on HelloPharmacist’s Agaricus Mushroom interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Agaricus Mushroom

86 medications have a known interaction with Agaricus Mushroom, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Agaricus Mushroom using our pharmacist-reviewed interaction data.

AI summaries are generated from our Agaricus Mushroom interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Agaricus Mushroom combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Agaricus Mushroom affects

Every type of medication (drug category) Agaricus Mushroom is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Agaricus Mushroom interacts with

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D

Monograph

Agaricus Mushroom: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not strong enough to recommend it for treating any disease. If you want to try it, talk with your pharmacist or doctor first, especially if you have a health condition or take other medicines.

Scientific name: Agaricus subrufescens
Family: Agaricaceae
Part used: Fruiting body (mushroom), sometimes mycelium
Common forms: Capsules, tablets, powders, dried mushroom, liquid extracts, teas

People commonly use it for

Immune support
General wellness and antioxidant
Adjunct interest during cancer care
Blood sugar support
Cholesterol and heart health

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally tolerated as a food, but supplement safety and long-term effects are not well established.

PregnancyBest avoided

Not enough safety data, so it is best to avoid supplement doses during pregnancy.

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Agaricus mushroom is a name used for several related edible mushrooms. The common button or white mushroom is Agaricus bisporus, while the type most often sold as a supplement is Agaricus blazei (also called Agaricus subrufescens), known as the Brazilian or sun mushroom. It is native to the Americas and is also widely grown in Brazil, Japan, and other countries.

People eat Agaricus mushrooms as food, but the mushroom is also dried and processed into capsules, powders, teas, and liquid extracts that are marketed for health support. Much of the supplement interest focuses on the Brazilian sun mushroom because of compounds found in its cell walls.

How it works

Agaricus mushrooms contain complex sugars called beta-glucans and other polysaccharides found in the mushroom cell wall. In laboratory and animal studies, these compounds appear to interact with the immune system and may help activate certain immune cells.

The mushroom also contains antioxidant compounds that may help reduce oxidative stress in test-tube studies. These mechanisms are mostly based on lab and animal research, and it is not clear how well they translate to real benefits in people.

Effectiveness

Does Agaricus Mushroom work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 12 uses evaluated

12 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

For Agaricus Mushroom, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 12 conditions — evidence insufficient to rate

Insufficient Reliable Evidence To Rate Allergic rhinitis (hay fever)