Herb & supplement monograph

Ginkgo Drug Interactions, Uses, Effectiveness, Safety & More

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Ginkgo Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Ginkgo drug interaction is moderate for many people, with bleeding risk the clearest concern. Nearly all of the listed interactions are rated moderate, only one is major, and a large share rest on theoretical or limited evidence.

Interactions deserving the most attention

The best-supported concern is bleeding: ginkgo may reduce the ability of platelets to clump, and serious bleeding has been reported with warfarin and other anticoagulant or antiplatelet drugs, including a fatal case involving ibuprofen. Human studies also show ginkgo can lower levels of alprazolam and simvastatin, which could weaken their effects. The single major-rated interaction, with the blood pressure drug talinolol, raised that drug's levels after repeated ginkgo use, and ginkgo may shift blood sugar responses in people on diabetes medicines.

What the rest of the list means

A long list of interactions does not mean every combination is harmful. Most entries are theoretical, based on how ginkgo might affect enzymes or transporters the body uses to clear medications, and several predicted effects have not caused meaningful changes when studied in people.

Check your medications against Ginkgo

Based on HelloPharmacist’s Ginkgo interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Ginkgo

1267 medications have a known interaction with Ginkgo, graded by severity. Select any drug for the full evidence-based detail.

1 major interaction. These combinations can be clinically significant — best avoided, or used only with close professional supervision. Always check with your pharmacist before combining them with Ginkgo.

2,830 drugs
TalinololTalinolol› Ado-trastuzumab EmtansineKadcyla› AbciximabReoPro› AbemaciclibVerzenio› Abiraterone› Abiraterone AcetateYonsa, Zytiga› AbrocitinibCibinqo› AcalabrutinibCalquence› AcarboseGlucobay, Prandase, Precose› AcenocoumarolSintrom› AcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength› Acetaminophen, AspirinGemnisyn› Acetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine› Acetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu› Acetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more› Acetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more› Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine› Acetaminophen, Butalbital, CodeineBancap w/ Codeine› Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3› Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound› Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more› Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3› Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS› Acetaminophen, Caffeine, IsomethepteneMigralam› Acetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual› Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief› Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex› Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu› Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief›
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Ginkgo combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Ginkgo affects

Every type of medication (drug category) Ginkgo is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 23 drug categories Ginkgo interacts with
TalinololAlprazolam (xanax)Anticoagulant/antiplatelet DrugsAnticonvulsantsAntidiabetes DrugsAtorvastatin (lipitor)Cytochrome P450 1a2 (cyp1a2) SubstratesCytochrome P450 2c19 (cyp2c19) SubstratesCytochrome P450 2c9 (cyp2c9) SubstratesCytochrome P450 3a4 (cyp3a4) SubstratesEfavirenz (sustiva)Ibuprofen (advil, Others)P-glycoprotein SubstratesRisperidone (risperdal)Rosiglitazone (avandia)Seizure Threshold Lowering DrugsSimvastatin (zocor)Sofosbuvir (sovaldi)Tacrolimus (prograf)Trazodone (desyrel)Warfarin (coumadin)Nifedipine (procardia)Omeprazole (prilosec)
Talinolol

Taking ginkgo with talinolol seems to increase blood levels of talinolol.
There is some evidence that using ginkgo leaf extract 120 mg orally three times daily for 14 days can increase levels of talinolol by 36% in healthy male individuals. However, single doses of ginkgo do not seem to affect talinolol pharmacokinetics.

Likelihood Probable Evidence B
Alprazolam (Xanax)

Theoretically, ginkgo might decrease the levels and clinical effects of alprazolam.
In clinical research, ginkgo extract (Ginkgold) 120 mg twice daily seems to decrease alprazolam levels by about 17%. However, ginkgo does not appear to decrease the elimination half-life of alprazolam. This suggests that ginkgo is more likely to decrease absorption of alprazolam rather than induce hepatic metabolism of alprazolam.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin. Theoretically, ginkgo might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs.
Several pharmacodynamic studies suggest that ginkgo inhibits platelet aggregation. It is thought that the ginkgo constituent, ginkgolide B, displaces platelet-activating factor (PAF) from its binding sites, decreasing blood coagulation. Several case reports have documented serious bleeding events in patients taking ginkgo. However, population and clinical studies have produced mixed results. Some evidence shows that short-term use of ginkgo leaf does not significantly reduce platelet aggregation and blood clotting. A study in healthy males who took a specific ginkgo leaf extract (EGb 761) 160 mg twice daily for 7 days found no change in prothrombin time. An analysis of a large medical record database suggests that ginkgo increases the risk of a bleeding adverse event by 38% when taken concurrently with warfarin. It has been suggested that ginkgo has to be taken for at least 2-3 weeks to have a significant effect on platelet aggregation. However, a meta-analysis of 18 studies using standardized ginkgo extracts, 80-480 mg daily for up to 32 weeks, did not find a significant effect on platelet aggregation, fibrinogen concentration, or PT/aPTT. In addition, a single dose of ginkgo plus clopidogrel or ticlopidine does not seem to significantly increase bleeding time or platelet aggregation. Also, taking ginkgo leaf extract daily for 8 days in conjunction with rivaroxaban does not affect anti-factor Xa activity; however, this study did not evaluate bleeding time.

Likelihood Possible Evidence A
Anticonvulsants

Theoretically, ginkgo might reduce the effectiveness of anticonvulsants.
Ginkgo seeds contain ginkgotoxin. Large amounts of ginkgotoxin can cause neurotoxicity and seizure. Ginkgotoxin is present in much larger amounts in ginkgo seeds than leaves. Ginkgo leaf extract contains trace amounts of ginkgotoxin. The amount of ginkgotoxin in ginkgo leaf and leaf extract seems unlikely to cause toxicity. However, there are anecdotal reports of seizure occurring after use of ginkgo leaf both in patients without a history of seizure disorder and in those with previously well-controlled epilepsy.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking ginkgo with antidiabetes drugs might alter the response to antidiabetes drugs.
Ginkgo leaf extract seems to alter insulin secretion and metabolism, and might affect blood glucose levels in people with type 2 diabetes. The effect of ginkgo seems to differ depending on the insulin and treatment status of the patient. In diet-controlled diabetes patients with hyperinsulinemia, taking ginkgo does not seem to significantly affect insulin or blood glucose levels. In patients with hyperinsulinemia who are treated with oral hypoglycemic agents, taking ginkgo seems to decrease insulin levels and increase blood glucose following an oral glucose tolerance test. Researchers speculate that this could be due to ginkgo-enhanced hepatic metabolism of insulin. In patients with pancreatic exhaustion, taking ginkgo seems to stimulate pancreatic beta-cells, resulting in increased insulin and C-peptide levels, but with no significant change in blood glucose levels in response to an oral glucose tolerance test.

Likelihood Possible Evidence B
Atorvastatin (Lipitor)

Theoretically, ginkgo might decrease the levels and clinical effects of atorvastatin.
In humans, intake of ginkgo extract appears to increase atorvastatin clearance, reducing the area under the curve of atorvastatin by 10% to 14% and the maximum concentration by 29%. However, this interaction does not appear to affect cholesterol synthesis and absorption. Further, a model in rats with hyperlipidemia suggests that administering ginkgo extract does not impact blood levels of atorvastatin and leads to lower total cholesterol, low-density lipoprotein cholesterol, and triglycerides when compared with rats given atorvastatin alone.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginkgo might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that ginkgo leaf extract can mildly inhibit CYP1A2 enzymes. However, clinical research suggests ginkgo might not affect CYP1A2. Until more is known, use ginkgo cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence B
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, ginkgo might decrease levels of drugs metabolized by CYP2C19.
Some clinical research shows that a specific ginkgo leaf extract (Remembrance, Herbs Product LTD) 140 mg twice daily can induce CYP2C19 enzymes and potentially decrease levels of drugs metabolized by these enzymes. However, other clinical research shows that taking ginkgo 120 mg twice daily for 12 days has no effect on levels of drugs metabolized by CYP2C19.

Likelihood Probable Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginkgo might increase levels of drugs metabolized by CYP2C9.
In vitro, a specific standardized extract of ginkgo leaf (EGb 761) inhibits CYP2C9 activity . The terpenoid (ginkgolides) and flavonoid (quercetin, kaempferol, etc.) constituents seem to be responsible for this effect. Most ginkgo extracts contain some amount of these constituents. Therefore, other ginkgo leaf extracts might also inhibit the CYP2C9 enzyme. However, clinical research suggests that ginkgo might not have a significant effect on CYP2C9 in humans. Ginkgo does not seem to significantly affect the pharmacokinetics of CYP2C9 substrates diclofenac or tolbutamide.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ginkgo might decrease levels of drugs metabolized by CYP3A4.
There is conflicting evidence about whether ginkgo induces or inhibits CYP3A4. Ginkgo does not appear to affect hepatic CYP3A4. However, it is not known if ginkgo affects intestinal CYP3A4. Preliminary clinical research suggests that taking ginkgo does not significantly affect levels of donepezil, lopinavir, or ritonavir, which are all CYP3A4 substrates. Other clinical research also suggests ginkgo does not significantly affect CYP3A4 activity. However, there are two case reports of decreased efavirenz concentrations and increased viral load in patients taking ginkgo. It is suspected that terpenoids from the ginkgo extract reduced drug levels by inducing cytochrome P450 3A4 (CYP3A4).

Likelihood Possible Evidence B
Efavirenz (Sustiva)

Theoretically, ginkgo might decrease the levels and clinical effects of efavirenz.
There are two case reports of decreased efavirenz concentrations and increased viral load in patients taking ginkgo. In one case, an HIV-positive male experienced over a 50% decrease in efavirenz levels over the course of 14 months while taking ginkgo extract. HIV-1 RNA copies also increased substantially, from less than 50 to more than 1500. It is suspected that terpenoids from the ginkgo extract reduced drug levels by inducing cytochrome P450 3A4 (CYP3A4). In another case report, a patient stable on antiviral therapy including efavirenz for 10 years, had an increase in viral load from <50 copies/mL to 1350 copies/mL after 2 months of taking a combination of supplements including ginkgo. After stopping ginkgo, the viral load was again controlled with the same antiviral therapy regimen.

Likelihood Possible Evidence D
Ibuprofen (Advil, Others)

Theoretically, ginkgo might increase the risk of bleeding when used with ibuprofen.
Ginkgo might have antiplatelet effects and has been associated with several case reports of spontaneous bleeding. In one case, a 71-year-old male had taken a specific ginkgo extract (Gingium, Biocur) 40 mg twice daily for 2.5 years. About 4 weeks after starting ibuprofen 600 mg daily he experienced a fatal intracerebral hemorrhage. However, the antiplatelet effects of ginkgo have been questioned. A meta-analysis and other studies have not found a significant antiplatelet effect with standardized ginkgo extracts, 80 mg to 480 mg taken daily for up to 32 weeks.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, taking ginkgo with P-glycoprotein substrates might increase the levels and adverse effects of these substrates.
A small clinical study in healthy volunteers shows that using ginkgo leaf extract 120 mg orally three times daily for 14 days can increase levels of the P-glycoprotein substrate, talinolol, by 36% in healthy male individuals. However, single doses of ginkgo do not have the same effect.

Likelihood Possible Evidence B
Risperidone (Risperdal)

Theoretically, taking ginkgo with risperidone might increase the levels and adverse effects of risperidone.
A single case of priapism has been reported for a 26-year-old male with schizophrenia who used risperidone 3 mg daily along with ginkgo extract 160 mg daily. Risperidone is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4. CYP3A4 activity might be affected by ginkgo. Theoretically, ginkgo may inhibit the metabolism of risperidone and increase the risk of adverse effects.

Likelihood Possible Evidence D
Rosiglitazone (Avandia)

Theoretically, ginkgo might decrease the levels and clinical effects of rosiglitazone.
Animal research shows that ginkgo leaf extract orally 100 or 200 mg/kg daily for 10 days alters the pharmacodynamics of rosiglitazone in a dose-dependent manner. The 100 mg/kg and 200 mg/kg doses reduce the area under the concentration time curve (AUC) of rosiglitazone by 39% and 52%, respectively, and the half-life by 28% and 39%, respectively. It is hypothesized that these changes may be due to induction of cytochrome P450 2C8 by ginkgo.

Likelihood Possible Evidence D
Seizure Threshold Lowering Drugs

Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.
Ginkgo seeds contain ginkgotoxin. Large amounts of ginkgotoxin can cause neurotoxicity and seizure. Ginkgotoxin is present in much larger amounts in ginkgo seeds than leaves. Ginkgo leaf extract contains trace amounts of ginkgotoxin. The amount of ginkgotoxin in ginkgo leaf and leaf extract seems unlikely to cause toxicity. However, there are anecdotal reports of seizure occurring after use of ginkgo leaf both in patients without a history of seizure disorder and in those with previously well-controlled epilepsy.

Likelihood Possible Evidence D
Simvastatin (Zocor)

Theoretically, ginkgo might decrease the levels and clinical effects of simvastatin.
Clinical research shows that taking ginkgo extract can reduce the area under the curve and maximum concentration of simvastatin by 32% to 39%. However, ginkgo extract does not seem to affect the cholesterol-lowering ability of simvastatin.

Likelihood Probable Evidence B
Sofosbuvir (Sovaldi)

Theoretically, ginkgo might increase the levels and clinical effects of sofosbuvir.
Animal research in rats shows that giving a ginkgo extract 25 mg/kg orally daily for 14 days increases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 11%, increases the half-life by 60%, and increases the plasma concentration at 4 hours by 38%. This interaction appears to be related to the inhibition of intestinal P-glycoprotein by ginkgo.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Theoretically, ginkgo might increase the blood levels of tacrolimus.
In vitro evidence suggests that certain biflavonoids in ginkgo leaves (i.e. amentoflavone, ginkgetin, bilobetin) may inhibit the metabolism of tacrolimus by up to 50%. This interaction appears to be time-dependent and due to inhibition of cytochrome P450 (CYP) 3A4 by these bioflavonoids. In rats given tacrolimus 1 mg/kg orally, amentoflavone was shown to increase the area under the concentration time curve (AUC) of tacrolimus by 3.8-fold.

Likelihood Possible Evidence D
Trazodone (Desyrel)

Theoretically, ginkgo might increase the levels and clinical effects of trazodone.
In a case report, an Alzheimer patient taking trazodone 20 mg twice daily and ginkgo leaf extract 80 mg twice daily for four doses became comatose. The coma was reversed by administration of flumazenil (Romazicon). Coma might have been induced by excessive GABA-ergic activity. Ginkgo flavonoids are thought to have GABA-ergic activity and act directly on benzodiazepine receptors. Ginkgo might also increase metabolism of trazodone to active GABA-ergic metabolites, possibly by inducing cytochrome P450 3A4 (CYP3A4) metabolism.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginkgo has been shown to increase the risk of bleeding in some people when taken with warfarin.
Several pharmacodynamic studies suggest that ginkgo inhibits platelet aggregation. It is thought that the ginkgo constituent, ginkgolide B, displaces platelet-activating factor (PAF) from its binding sites, decreasing blood coagulation. Several case reports have documented serious bleeding events in patients taking ginkgo. Information from a medical database suggests that when taken concurrently with warfarin, ginkgo increases the risk of a bleeding adverse event by 38%. There is also some evidence that ginkgo leaf extract can inhibit cytochrome P450 2C9, an enzyme that metabolizes warfarin. This could result in increased warfarin levels. However, population and clinical research has produced mixed results. Clinical research in healthy people suggests that ginkgo has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. A meta-analysis of 18 studies using standardized ginkgo extracts, 80 mg to 480 mg daily for up to 32 weeks, did not find a significant effect on platelet aggregation, fibrinogen concentration, or PT/aPTT. There is also some preliminary clinical research that suggests ginkgo might not significantly increase the effects of warfarin in patients that have a stable INR.

Likelihood Possible Evidence B
Nifedipine (Procardia)

Theoretically, taking ginkgo with oral, but not intravenous, nifedipine might increase levels and adverse effects of nifedipine.
Animal research and some clinical evidence suggests that taking ginkgo leaf extract orally in combination with oral nifedipine might increase nifedipine levels and cause increased side effects, such as headaches, dizziness, and hot flushes. However, taking ginkgo orally does not seem to affect the pharmacokinetics of intravenous nifedipine.

Likelihood Possible Evidence B
Omeprazole (Prilosec)

Theoretically, taking ginkgo with omeprazole might decrease the levels and clinical effects of omeprazole.
Clinical research shows that a specific ginkgo leaf extract (Remembrance, Herbs Product LTD) 140 mg twice daily can induce cytochrome P450 (CYP) 2C19 enzymes and decrease levels of omeprazole by about 27% to 42%.

Likelihood Possible Evidence B
Monograph

Ginkgo: Uses, Safety & Side Effects

The bottom line

Ginkgo is one of the world's most popular herbal supplements, mostly taken to support memory and circulation. The evidence for these uses is mixed and generally weak, and it is not proven to prevent memory loss or dementia. It is usually well tolerated in healthy adults, but it can thin the blood, so talk to your pharmacist or doctor before using it.

Ginkgo
Scientific name
Ginkgo biloba
Family
Ginkgoaceae
Part used
Leaves (standardized leaf extract); seeds are used in some traditional preparations
Common forms
Capsules, tablets, standardized liquid extracts, tea
People commonly use it for
  • Memory and cognitive support
  • Age-related mental decline
  • Circulation problems
  • Tinnitus (ringing in the ears)
  • Dizziness or vertigo

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated in healthy adults but may increase bleeding risk, so use with caution.

PregnancyPossibly Unsafe

When used orally. There is concern that ginkgo might have labor-inducing and hormonal effects. There is also concern that the antiplatelet effects of...

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Ginkgo comes from the Ginkgo biloba tree, one of the oldest living tree species on Earth. It is native to China and is now grown around the world. The tree is easy to recognize by its fan-shaped leaves.

Most supplements use an extract made from the dried green leaves. This extract is usually standardized to contain certain plant compounds, such as flavonoids and terpene lactones. Ginkgo is one of the best-selling herbal products worldwide.

People most often take ginkgo hoping to support memory, thinking, and blood flow. It has a long history in traditional Chinese medicine, where the leaves and seeds have both been used.

How it works

Ginkgo leaf extract contains two main groups of active compounds: flavonoids (plant antioxidants) and terpene lactones (such as ginkgolides and bilobalide).

Researchers believe these compounds may help by improving blood flow, relaxing blood vessels, and protecting cells from damage caused by unstable molecules called free radicals. Ginkgolides may also affect how blood platelets stick together, which is why ginkgo can have a mild blood-thinning effect.

It is important to know that much of this information comes from laboratory and animal studies. How well these effects translate into real benefits in people is still not fully clear.

Effectiveness

Does Ginkgo work?

Evidence overview · 59 uses evaluated
8 Possibly effective 5 Leans ineffective 46 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Effective Anxiety
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo seems to modestly reduce anxiety symptoms.

Possibly Effective Dementia
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo 240 mg seems to improve symptoms of various types of dementia, but lower doses are not always effective. Oral ginkgo does not seem to prevent or slow down the progression of dementia.

Possibly Effective Hearing loss
Rating & evidence shown verbatim from Natural Medicines

Intravenous ginkgo appears to improve hearing loss when used in conjunction with corticosteroids. The effectiveness of oral ginkgo is unclear.

Possibly Effective Premenstrual syndrome (PMS)
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo seems to reduce symptoms of PMS.

Possibly Effective Schizophrenia
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo seems to reduce total and negative symptoms of schizophrenia, and may be beneficial for reducing antipsychotic-associated adverse effects.

Possibly Effective Stroke
Rating & evidence shown verbatim from Natural Medicines

Oral and intravenous ginkgo may modestly improve certain aspects of neurological recovery from both hemorrhagic and ischemic stroke; intravenous ginkgo might be more effective.

Possibly Effective Tardive dyskinesia
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo seems to reduce the severity of tardive dyskinesia in schizophrenic patients being treated with antipsychotic medications.

Possibly Effective Vertigo
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo seems to improve symptoms of vertigo in people with vestibular disorders. It is unclear if it is beneficial for vertigo caused by cerebral arteriosclerosis.

Possibly Ineffective Age-related cognitive decline
Rating & evidence shown verbatim from Natural Medicines

Most research shows that oral ginkgo does not improve symptoms of age-related cognitive impairment.

Possibly Ineffective Cardiovascular disease (CVD)
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo does not seem to prevent CVD.

Possibly Ineffective Chemotherapy-related cognitive impairment
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo does not seem to improve symptoms of cognitive impairment in people using chemotherapy.

Possibly Ineffective Multiple sclerosis (MS)
Rating & evidence shown verbatim from Natural Medicines

Most research shows that oral ginkgo does not improve symptoms of MS.

Possibly Ineffective Tinnitus
Rating & evidence shown verbatim from Natural Medicines

Most research shows that oral ginkgo does not improve symptoms of tinnitus.

Also studied for 46 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Age-related macular degeneration (AMD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in AMD.

Insufficient Reliable Evidence To Rate Aging
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for aging, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Allergic rhinitis (hay fever)
Rating & evidence shown verbatim from Natural Medicines

Topical ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Altitude sickness
Rating & evidence shown verbatim from Natural Medicines

Research on the use of oral ginkgo for altitude sickness is conflicting.

Insufficient Reliable Evidence To Rate Angina
Rating & evidence shown verbatim from Natural Medicines

Some low-quality evidence suggests that oral ginkgo may reduce angina symptoms when taken in addition to standard of care.

Insufficient Reliable Evidence To Rate Asthma
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Attention deficit-hyperactivity disorder (ADHD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in ADHD.

Insufficient Reliable Evidence To Rate Autism spectrum disorder
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in children with autism.

Insufficient Reliable Evidence To Rate Bronchitis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for bronchitis, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Chronic kidney disease (CKD)
Rating & evidence shown verbatim from Natural Medicines

There is limited evidence on the intravenous use of ginkgo leaf extract in adults with hypertensive nephropathy. It has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Chronic obstructive pulmonary disease (COPD)
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Cocaine dependence
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for maintenance of abstinence from cocaine.

Insufficient Reliable Evidence To Rate Cognitive function
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for cognitive function.

Insufficient Reliable Evidence To Rate Cognitive impairment
Rating & evidence shown verbatim from Natural Medicines

It is unclear if ginkgo is beneficial for cognitive impairment.

Insufficient Reliable Evidence To Rate Colorectal cancer
Rating & evidence shown verbatim from Natural Medicines

Intravenous ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Cough
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for cough, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Depression
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in depression.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Research on the use of oral ginkgo in type 2 diabetes is conflicting.

Insufficient Reliable Evidence To Rate Diabetic retinopathy
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for this condition.

Insufficient Reliable Evidence To Rate Dry eye
Rating & evidence shown verbatim from Natural Medicines

Ginkgo eye drops have only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Dyslexia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for dyslexia in children.

Insufficient Reliable Evidence To Rate Fibromyalgia
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Gastric cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in gastric cancer.

Insufficient Reliable Evidence To Rate Glaucoma
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in glaucoma.

Insufficient Reliable Evidence To Rate Hemorrhoids
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Hypercholesterolemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for hypercholesterolemia, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Intestinal parasite infection
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for intestinal parasite infection, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Lyme disease
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for cognitive dysfunction associated with Lyme disease, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Metabolic dysfunction-associated steatotic liver disease (MASLD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in patients with MASLD.

Insufficient Reliable Evidence To Rate Migraine headache
Rating & evidence shown verbatim from Natural Medicines

Oral ginkgolide B, a constituent of ginkgo biloba extract, has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Ovarian cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in preventing ovarian cancer.

Insufficient Reliable Evidence To Rate Pancreatic cancer
Rating & evidence shown verbatim from Natural Medicines

Intravenous ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Parkinson disease
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for drug-induced Parkinsonism.

Insufficient Reliable Evidence To Rate Peripheral arterial disease (PAD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial in PAD.

Insufficient Reliable Evidence To Rate Pulmonary hypertension
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intravenous ginkgo is beneficial in patients with pulmonary hypertension and cor pulmonale.

Insufficient Reliable Evidence To Rate Quality of life
Rating & evidence shown verbatim from Natural Medicines

Some preliminary clinical studies suggest that oral ginkgo might improve quality of life in elderly individuals.

Insufficient Reliable Evidence To Rate Radiation dermatitis
Rating & evidence shown verbatim from Natural Medicines

Topical ginkgo has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Radiation exposure
Rating & evidence shown verbatim from Natural Medicines

It is unclear if intravenous ginkgo is beneficial in people who have been exposed to radiation.

Insufficient Reliable Evidence To Rate Raynaud syndrome
Rating & evidence shown verbatim from Natural Medicines

Evidence for the use of oral ginkgo for flare reduction is conflicting.

Insufficient Reliable Evidence To Rate Scabies
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical ginkgo for scabies, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Seasonal affective disorder (SAD)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for SAD.

Insufficient Reliable Evidence To Rate Sexual dysfunction
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for sexual dysfunction in females.

Insufficient Reliable Evidence To Rate Venous thromboembolism (VTE)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral ginkgo for thrombosis, there is insufficient reliable information about the clinical effects of ginkgo for this condition.

Insufficient Reliable Evidence To Rate Vitiligo
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral ginkgo is beneficial for reducing vitiligo progression.

Insufficient Reliable Evidence To Rate Wound healing
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using topical ginkgo for healing of skin sores or chilblains, there is insufficient reliable information about the clinical effects of ginkgo for these conditions.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

For most healthy adults, standardized ginkgo leaf extract appears to be reasonably safe when used short-term. However, because it may slow blood clotting, people with bleeding disorders or those scheduled for surgery should be cautious and usually stop it ahead of time. Let your surgeon and pharmacist know if you take it.

People with a history of seizures should be careful, as some reports suggest ginkgo could lower the seizure threshold, especially if a product is contaminated with ginkgo seeds.

Pregnancy and breastfeeding: There is not enough reliable safety information, and the possible blood-thinning effect is a concern. It is best to avoid ginkgo if you are pregnant or breastfeeding.

Never eat raw or roasted ginkgo seeds (nuts), which can be toxic, especially in children. Always choose products from reputable brands, ideally with third-party testing.

Side effects

Ginkgo is usually well tolerated, but some people may have mild side effects, including:

  • Headache
  • Upset stomach or nausea
  • Dizziness
  • Constipation or diarrhea
  • Skin reactions or allergic rash

More serious but rare concerns include increased bleeding or bruising. There have been case reports of bleeding in the brain or eye in people taking ginkgo, though a direct cause is not proven. People allergic to poison ivy or related plants may be more likely to have a skin reaction. Stop ginkgo and seek medical care if you notice unusual bleeding.

Ginkgo: Reported Adverse Effects

Documented safety reports on Ginkgo from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, ginkgo leaf extract is generally well tolerated when used for up to 6 years. However, the seed and crude plant contain toxic constituents and should be avoided.

Intravenously, ginkgo leaf extract seems to be well tolerated when used for up to 30 days.

Topically, no adverse effects have been reported with ginkgo as a single ingredient. However, a thorough evaluation of safety outcomes has not been conducted.

Most Common Adverse Effects:

Orally: Dizziness, gastrointestinal symptoms, headache.

Serious Adverse Effects (Rare):

Orally: Arrhythmia, bleeding, Stevens-Johnson syndrome.

Reports by condition
Arrhythmia Cardiovascular

Cardiac arrhythmias suspected to be related to ginkgo have been reported. Internationally, there are at least 162 reports from 18 countries, with 34% of cases considered serious, involving five deaths and four life-threatening events. Additionally, a report from Canada found that 10 out of 15 cases of arrhythmia were considered serious. Ginkgo was the only suspect ingredient in 57% of all international reports, with symptoms generally presenting within days of initiation. The most common symptoms included palpitations, tachycardia, bradycardia, syncope, and loss of consciousness. Most cases were reported to be related to oral use of ginkgo leaf products; however, some cases were associated with oral use of the seed, and others with intravenous or intramuscular use of the leaf. Documented discontinuation of ginkgo led to recovery in approximately 84% of cases where ginkgo was the sole suspect. Despite these findings, ginkgo cannot be confirmed as the causal agent. It is possible that these reports are confounded by underlying co-morbidities. Of the reported cases, the main reason for ginkgo use was tinnitus, a symptom commonly associated with pre-existing arrhythmias. Despite this large number of reports, only three cases of cardiac arrhythmia have been published in the literature. In one case, frequent nocturnal episodes of paroxysmal atrial fibrillation were reported for a 35-year-old female taking ginkgo extract 240 mg daily orally for 2 months. Arrythmias ceased following discontinuation of ginkgo.

Increases in blood pressure were commonly reported with ginkgo in a safety database analysis; however, information on the magnitude of the increase was limited, and reports included both oral and intravenous administration.

In one clinical trial, the rate of ischemic stroke and transient ischemic attacks was significantly higher in patients taking ginkgo extract orally when compared with placebo. It is unclear if these events were due to ginkgo, other factors, or a combination.

  1. World Health Organization. WHO pharmaceuticals newsletter: 2020, No. 3. Available at: https://www.who.int/medicines/publications/WHO_Pharmaceuticals_Newslet3_20.pdf?ua=1. Accessed June 23, 2021.
  2. Health Canada. Ginkgo biloba-containing products and the risk of cardiac arrhythmias. Health Product InfoWatch. February 2021. Available at: https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/health-product-infowatch/fe
  3. Russo, V., Rago, A., Russo, G. M., Calabro, R., and Nigro, G. Ginkgo biloba: an ancient tree with new arrhythmic side effects. J Postgrad.Med 2011;57(3):221.
  4. Yao Y, Zhao J, Li C, et al. Ginkgo biloba extract safety: Insights from a real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events. J Ethnopharmacol 2025;337(Pt 3):119010.
  5. Dodge HH, Zitzelberger T, Oken BS, et al. A randomized placebo-controlled trial of ginkgo biloba for the prevention of cognitive decline. Neurology 2008;70(19 Pt 2):1809-17.
Cirrhosis Hematologic

Spontaneous bleeding is one of the most concerning potential side effects associated with ginkgo. There are several published case reports linking ginkgo to episodes of minor to severe bleeding; however, not all case reports clearly establish ginkgo as the cause of bleeding. In most cases, other bleeding risk factors were also present including taking other medications or natural medicines, old age, liver cirrhosis, recent surgery, and other conditions. In most cases, bleeding occurred after several weeks or months of taking ginkgo. Large-scale clinical trials and a meta-analysis evaluating standardized ginkgo leaf extracts show that the incidence of bleeding in patients taking ginkgo is not significantly higher than in those taking placebo.

There are several case reports of intracerebral bleeding. Some of these cases resulted in permanent neurological damage and one case resulted in death.

There are at least 4 cases of ocular bleeding including spontaneous hyphema (bleeding from the iris into the anterior part of the eye) and retrobulbar hemorrhage associated with ginkgo use.

There are also cases of surgical and post-surgical complications in patients using ginkgo. Retrobulbar hemorrhage (bleeding behind the eye) during cataract surgery has been associated with ginkgo use. Excessive postoperative bleeding requiring transfusion has also occurred following laparoscopic surgery in a patient who had been taking ginkgo leaf extract. There have also been two cases of excessive bleeding during surgery and post-surgical hematoma in patients undergoing rhytidoplasty and blepharoplasty. In another case, an elderly patient taking ginkgo experienced excessive postoperative bleeding following total hip arthroplasty. In another case, use of ginkgo following liver transplantation surgery was associated with subphrenic hematoma requiring evacuation by laparotomy. The patient also subsequently experienced vitreous hemorrhage. In another case, an elderly patient who had taken ginkgo chronically experienced excessive post-operative bleeding following an ambulatory surgical procedure.

In another case, an elderly man experienced nose bleeds and ecchymosis following use of ginkgo. One case of diffuse alveolar hemorrhage in a female taking ginkgo and ginseng for over one year has been reported. These instances of bleeding stopped when ginkgo was discontinued, and recurred when the patient started taking ginkgo again.

Persistent bleeding has also occurred following dental surgery and laparoscopic cholecystectomy. Nosebleed has also been reported as an adverse effect in a clinical trial.

  1. Bent S, Goldberg H, Padula A, Avins AL. Spontaneous bleeding associated with Ginkgo biloba: a case report and systematic review of the literature. J Gen Intern Med 2005;20;657-61.
  2. DeKosky ST, Williamson JD, Fitzpatrick AL, et al. Ginkgo biloba for prevention of dementia. JAMA 2008;300:2253-62.
  3. Dodge HH, Zitzelberger T, Oken BS, et al. A randomized placebo-controlled trial of ginkgo biloba for the prevention of cognitive decline. Neurology 2008;70(19 Pt 2):1809-17.
  4. Kellermann AJ, Kloft C. Is there a risk of bleeding associated with standardized ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy 2011;31:490-502.
  5. Kuller LH, Ives DG, Fitzpatrick AL, et al. Does Ginkgo biloba reduce the risk of cardiovascular events? Circ Cardiovasc Qual Outcomes 2010;3:41-7.
  6. Benjamin J, Muir T, Briggs K, Pentland B. A case of cerebral haemorrhage-can Ginkgo biloba be implicated? Postgrad Med J 2001;77:112-3.
  7. Rowin J, Lewis SL. Spontaneous bilateral subdural hemotomas with chronic Ginkgo biloba ingestion. Neurology 1996;46:1775-6.
  8. Miller LG, Freeman B. Possible subdural hematoma associated with Ginkgo biloba. J Herb Pharmacother 2002;2:57-63.
  9. Meisel C, Johne A, Roots I. Fatal intracerebral mass bleeding associated with Ginkgo biloba and ibuprofen. Atherosclerosis 2003;167:367.
  10. Vale S. Subarachnoid haemorrhage associated with Ginkgo biloba. Lancet 1998;352:36.
  11. Pedroso, J. L., Henriques Aquino, C. C., Escorcio Bezerra, M. L., Baiense, R. F., Suarez, M. M., Dutra, L. A., Braga-Neto, P., and Povoas Barsottini, O. G. Ginkgo biloba and cerebral bleeding: a case report and critical review. Neurologist. 2011;17(2):89
  12. Skogh, M. Extracts of Ginkgo biloba and bleeding or haemorrhage. Lancet 10-3-1998;352(9134):1145-1146.
  13. Rosenblatt M, Mindel T. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 1997;336:1108.
  14. Fong KC, Kinnear PE. Retrobulbar haemorrhage associated with chronic Ginkgo biloba ingestion. Postgrad Med J 2003;79:531-2..
  15. Fessenden JM, Wittenborn W, Clarke L. Gingko biloba: a case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am Surg 2001;67:33-5.
  16. Destro MW, Speranzini MB, Cavalheiro Filho C, et al. Bilateral haematoma after rhytidoplasty and blepharoplasty following chronic use of Ginkgo biloba. Br J Plast Surg 2005;58:100-1.
  17. Bebbington A, Kulkarni R, Roberts P. Ginkgo biloba: Persistent bleeding after total hip arthroplasty caused by herbal self-medication. J Arthroplasty 2005;20:125-6. .
  18. Hauser D, Gayowski T, Singh N. Bleeding complications precipitated by unrecognized Gingko biloba use after liver transplantation. Transpl Int 2002;15:377-9.
  19. Yagmur E, Piatkowski A, Groger A, et al. Bleeding complication under Gingko biloba medication. Am J Hematol 2005;79:343-4.
  20. Carlile PV. Unexplained alveolar hemorrhage associated with ginkgo and ginseng use. J Bronchology Interv Pulmonol. 2015;22(2):170-2. doi: 10.1097/LBR.0000000000000150.
  21. Patel, N. Herbal remedies. Br.Dent.J 8-28-2010;209(4):153.
  22. Fessenden JM, Wittenborn W, and Clarke L. Ginkgo biloba: a case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am Surg 2001;67(1):33-35.
  23. May, B. H., Yang, A. W., Zhang, A. L., Owens, M. D., Bennett, L., Head, R., Cobiac, L., Li, C. G., Hugel, H., Story, D. F., and Xue, C. C. Chinese herbal medicine for Mild Cognitive Impairment and Age Associated Memory Impairment: a review of randomised
Cluster headache Neurologic/CNS

Orally, ginkgo extract may cause headache, dizziness, increased desire to sleep, and sedation in some patients. In addition, although ginkgo leaf and ginkgo leaf extract contain only small amounts of ginkgotoxin, there are anecdotal reports of seizure occurring after use of ginkgo leaf preparations both in patients without a history of seizure disorder and in those with previously well-controlled epilepsy.

  1. Cesarani A, Meloni F, Alpini D, et al. Ginkgo biloba (EGb 761) in the treatment of equilibrium disorders. Adv Ther 1998;15:291-304.
  2. Burschka MA, Hassan HA, Reineke T, et al. Effect of treatment with Ginkgo biloba extract EGb 761 (oral) on unilateral idiopathic sudden hearing loss in a prospective randomized double-blind study of 106 outpatients. Eur Arch Otorhinolaryngol 2001;258:213-
  3. Choi, W. S., Choi, C. J., Kim, K. S., Lee, J. H., Song, C. H., Chung, J. H., Ock, S. M., Lee, J. B., and Kim, C. M. To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phe
  4. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol 2000;40:647-54.
  5. Ozgoli, G., Selselei, E. A., Mojab, F., and Majd, H. A. A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome. J Altern.Complement Med 2009;15(8):845-851.
  6. Yao Y, Zhao J, Li C, et al. Ginkgo biloba extract safety: Insights from a real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events. J Ethnopharmacol 2025;337(Pt 3):119010.
  7. Kang BJ, Lee SJ, Kim MD, Cho MJ. A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction. Hum Psychopharmacol 2002;17:279-84.
  8. Gregory PJ. Seizure associated with Ginkgo biloba? Ann Intern Med 2001;134:344.
  9. Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing 2001;30:523-5.
  10. Arenz A, Kelin M, Flehe K, et al. Occurrence of neurotoxic 4'-O-methylpyridoxine in ginkgo biloba leaves, ginkgo medications and Japanese ginkgo food. Planta Med 1996;62:548-51.
  11. Kupiec T, Raj V. Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J Anal Toxicol 2005:755-8.
Constipation Gastrointestinal

Orally, ginkgo extract may cause mild gastrointestinal discomfort or pain, nausea and vomiting, diarrhea, dry mouth, and constipation. However, post-market surveillance suggests that the incidence of these events is relatively low, occurring in less than 2% of patients.

Fresh ginkgo seeds can cause stomach ache, nausea, vomiting, or diarrhea. Ingesting roasted seeds in amounts larger than the normal food amounts of 8-10 seeds per day, or long-term, can also cause these same adverse reactions.

  1. Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 1998;24:139-43.
  2. Burschka MA, Hassan HA, Reineke T, et al. Effect of treatment with Ginkgo biloba extract EGb 761 (oral) on unilateral idiopathic sudden hearing loss in a prospective randomized double-blind study of 106 outpatients. Eur Arch Otorhinolaryngol 2001;258:213-
  3. Salehi B, Imani R, Mohammadi MR, et al. Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents: a double blind, randomized controlled trial. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:76-80.
  4. Choi, W. S., Choi, C. J., Kim, K. S., Lee, J. H., Song, C. H., Chung, J. H., Ock, S. M., Lee, J. B., and Kim, C. M. To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phe
  5. Nicolai, S. P., Gerardu, V. C., Kruidenier, L. M., Prins, M. H., and Teijink, J. A. From the Cochrane library: Ginkgo biloba for intermittent claudication. Vasa 2010;39(2):153-158.
  6. Parsad, D., Pandhi, R., and Juneja, A. Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo. Clin Exp.Dermatol. 2003;28(3):285-287.
  7. Singh, V., Singh, S. P., and Chan, K. Review and meta-analysis of usage of ginkgo as an adjunct therapy in chronic schizophrenia. Int J Neuropsychopharmacol. 2010;13(2):257-271.
  8. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol 2000;40:647-54.
  9. Lovera, J., Bagert, B., Smoot, K., Morris, C. D., Frank, R., Bogardus, K., Wild, K., Oken, B., Whitham, R., and Bourdette, D. Ginkgo biloba for the improvement of cognitive performance in multiple sclerosis: a randomized, placebo-controlled trial. Mult.S
  10. Burkard G. [The efficacy and safety of ginkgo biloba extract in dementia]. Fortschr Med [Supp] 1991;109(107):6-8.
  11. Kajiyama Y, Fujii K, Takeuchi H, Manabe Y. Ginkgo seed poisoning. Pediatrics 2002;109:325-7.
  12. Miwa H, Iijima M, Tanaka S, Mizuno Y. Generalized convulsions after consuming a large amount of gingko nuts. Epilepsia 2001;42:280-1.
Dermatitis Dermatologic

Topically, ginkgo fruit pulp can cause contact dermatitis, with intense itching, edema, papules, and pustules which take 7-10 days to resolve after stopping contact.

  1. Burnett CL, Bergfeld WF, Belsito DV, et al. Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics. Int J Toxicol. 2023 Nov 6:10915818231210792.
Erythema Immunologic

Orally, ginkgo leaf extract can cause allergic skin reactions in some patients. In one case, a patient developed acute generalized exanthematous pustulosis 48 hours after taking a single-ingredient ginkgo product. The rash resolved within 10 days after discontinuing ginkgo. In another case, progressive erythema of the face, neck, trunk, and extremities occurred after two 60 mg oral doses of ginkgo extract. There is also a case of Stevens-Johnson syndrome following a second administration of a preparation containing ginkgo leaf extract, choline, vitamin B6, and vitamin B12. In another case, systemic edema and severe arthralgia was reported after contact with a ginkgo tree nut and manifested as multifocal lymphadenopathy associated with an allergic reaction on PET/CT scan imaging.

  1. Pennisi RS. Acute generalised exanthematous pustulosis induced by the herbal remedy Ginkgo biloba. Med J Aust 2006;184:583-4.
  2. Woelk H, Arnoldt KH, Kieser M, Hoerr R. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial. J Psychiatr Res 2007;41:472-80.
  3. Burnett CL, Bergfeld WF, Belsito DV, et al. Safety Assessment of Ginkgo biloba-Derived Ingredients as Used in Cosmetics. Int J Toxicol. 2023 Nov 6:10915818231210792.
  4. Davydov L, Stirling AL. Stevens-Johnson syndrome with Ginkgo biloba. J Herb Pharmacother 2001;1:65-9.
  5. Han EJ, Park HL, Kim SH. Allergic Reaction to Ginkgo Nut on FDG PET/CT. Clin Nucl Med. 2016 Sep;41(9):716-7. doi: 10.1097/RLU.0000000000001276.
Myasthenia gravis Musculoskeletal
Myasthenia gravis Psychiatric

Orally, ginkgo has been associated with a single case of mood dysregulation. A 50-year-old female with schizophrenia developed irritability, difficulty controlling anger, and agitation after one week of taking ginkgo 80 mg twice daily. The mood changes resolved within 2-3 days of discontinuation. When ginkgo was re-trialed at a later date, the same symptoms reappeared, and again dissipated after discontinuation of the ginkgo product. The relationship between ginkgo and mood dysregulation was considered to be "probable" based on the Naranjo adverse drug reaction probability scale; however, the exact mechanism by which ginkgo may have affected mood regulation is unknown.

  1. Rho SS, Woo YS, Bahk WM. Ginkgo biloba induced mood dysregulation: a case report. BMC Complement Altern Med. 2018 Jan 15;18(1):14.
Tinnitus Ocular/Otic
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no single official dose for ginkgo, and the right amount depends on the product and reason for use. Studies have used standardized leaf extracts, but strengths vary a lot between brands.

The best approach is to follow the directions on the product label and not take more than recommended. Look for products that list a standardized extract and ideally have third-party quality testing.

Because ginkgo can affect bleeding and may not be right for everyone, check with your pharmacist or doctor before starting it, especially if you take other medicines or have a health condition.

Pregnancy & Breastfeeding

Ginkgo & Pregnancy

Possibly Unsafe

When used orally. There is concern that ginkgo might have labor-inducing and hormonal effects. There is also concern that the antiplatelet effects of ginkgo could prolong bleeding time if taken around the time of labor and delivery. Theoretically, ginkgo might adversely affect pregnancy outcome; avoid using during pregnancy.

  1. Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol 2006;13:e277-84.

Ginkgo & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 97 references that drive our Ginkgo monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Davydov L, Stirling AL. Stevens-Johnson syndrome with Ginkgo biloba. J Herb Pharmacother 2001;1:65-9. DOI
  2. Benjamin J, Muir T, Briggs K, Pentland B. A case of cerebral haemorrhage-can Ginkgo biloba be implicated? Postgrad Med J 2001;77:112-3.
  3. Matthews, MK. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology 1998;50:1934.
  4. Rowin J, Lewis SL. Spontaneous bilateral subdural hemotomas with chronic Ginkgo biloba ingestion. Neurology 1996;46:1775-6.
  5. Rosenblatt M, Mindel T. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 1997;336:1108.
  6. Fessenden JM, Wittenborn W, Clarke L. Gingko biloba: a case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy. Am Surg 2001;67:33-5. DOI
  7. Gurley BJ, Gardner SF, Hubbard MA. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. AAPS Ann Mtg & Expo Indianapolis, IN: 2000; Oct 29 - Nov 2:presentation #3460.
  8. Cohen AJ, Bartlik B. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 1998;24:139-43. PubMed
  9. Kudolo GB. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol 2000;40:647-54.
  10. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  11. Cesarani A, Meloni F, Alpini D, et al. Ginkgo biloba (EGb 761) in the treatment of equilibrium disorders. Adv Ther 1998;15:291-304.
  12. Galluzzi S, Zanetti O, Binetti G, et al. Coma in a patient with Alzheimer's disease taking low dose trazodone and Ginkgo biloba. J Neurol Neurosurg Psychiatry 2000;68:679-80. DOI
  13. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  14. Gregory PJ. Seizure associated with Ginkgo biloba? Ann Intern Med 2001;134:344.
  15. Granger AS. Ginkgo biloba precipitating epileptic seizures. Age Ageing 2001;30:523-5. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Product directory

Supplement products with Ginkgo

4,437 products in our database contain Ginkgo. Open any to see its full ingredient list and every drug interaction we check.

Ultra Vita Man Sport by Vitamin World Tablet Or Pill 90 Coated Tablet(s) Off market View ingredients & interactions Ultra Woman 50 Plus by Vitamin World Other (e.g. Tea Bag) 120 Coated Caplet(s) Off market View ingredients & interactions Ultra Woman Daily Multi by Vitamin World Other (e.g. Tea Bag) 90 Coated Caplet(s) Off market View ingredients & interactions Ultra Woman Iron Free Multi by Vitamin World Other (e.g. Tea Bag) 90 Coated Caplet(s) Off market View ingredients & interactions Ultra Woman Sport by Vitamin World Other (e.g. Tea Bag) 90 Coated Caplet(s) Off market View ingredients & interactions Ultraman High Potency by Nature's Bounty Tablet Or Pill 50 Tablet(s) Off market View ingredients & interactions Uni-Pros-Trol by Douglas Laboratories Capsule 60 Capsule(s) Off market View ingredients & interactions Uni-Vite by Universal Capsule 120 Capsule(s) Off market View ingredients & interactions Uni-Vite by Universal Capsule 120 Capsule(s) Off market View ingredients & interactions UVO Orange Peach Flavor by UVO Powder 0.26 oz. · 7.4 Gram(s) Off market View ingredients & interactions V 30+ by SNI Essentials Capsule 60 Capsule(s) Off market View ingredients & interactions V:V 7 Supplement by Douglas Laboratories Capsule 60 Capsule(s) Off market View ingredients & interactions V:V 7 Supplement by Douglas Laboratories Capsule 60 Capsule(s) Off market View ingredients & interactions V:V 7 Supplement by Douglas Laboratories Capsule 60 Capsule(s) Off market View ingredients & interactions Vari-Vein by Crystal Star Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Vari-Vein by Crystal Star Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Vascular Maintenance by ProSol Capsule 60 Vegetarian Capsule(s) Off market View ingredients & interactions Venix by Pharmanex Capsule 120 Capsule(s) Off market View ingredients & interactions Venix by Pharmanex Capsule 120 Capsule(s) Off market View ingredients & interactions Vialafil by NewtonEverett Capsule 30 Capsule(s) Off market View ingredients & interactions Vialafil 1350 mg by NewtonEverett Biotech Capsule 30 Capsule(s) Off market View ingredients & interactions Vialafil 675 mg by NewtonEverett Capsule 30 Capsule(s) Off market View ingredients & interactions Vialafil XR by NewtonEverett Biotech Capsule 30 Capsule(s) Off market View ingredients & interactions Vialafil XR 1350 mg by NewtonEverett Biotech Capsule 30 Capsule(s) Off market View ingredients & interactions
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Ginkgo: Common Questions

What is Ginkgo used for, and does it work?
People use Ginkgo for many reasons, but the evidence varies by use. According to the Natural Medicines database, there is at least some clinical evidence supporting Ginkgo for Anxiety, Dementia, Hearing loss and Premenstrual syndrome (PMS). For most other uses it has been studied for, the evidence is currently insufficient to rate. See the graded list on this page, and always confirm with your pharmacist or doctor.
Does Ginkgo interact with prescription medications?
Yes. We list 1267 medications with a known interaction with Ginkgo, including 1 rated major. Use the checker above to see how Ginkgo interacts with a specific drug.
How are Ginkgo interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Ginkgo with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Ginkgo interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
Does Ginkgo really improve memory?
The evidence is mixed and generally weak. Ginkgo is not proven to prevent memory loss or dementia in healthy people, and any benefit appears small at best.
Is Ginkgo safe to take every day?
Many healthy adults tolerate standardized Ginkgo leaf extract for short periods, but it can thin the blood and may not be right for everyone. Talk to your pharmacist or doctor before using it regularly.
Can I take Ginkgo while pregnant or breastfeeding?
No. There isn't enough safety information, and Ginkgo's possible blood-thinning effect is a concern, so it is best avoided during pregnancy and breastfeeding.
Are Ginkgo seeds the same as the supplement?
No. Supplements use the leaf extract, while raw or roasted Ginkgo seeds (nuts) can be toxic and should not be eaten, especially by children.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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