Herb & supplement monograph

Hesperidin Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Hesperidin interacts with medications. The heart of this page is the interaction list — every drug Hesperidin is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Hesperidin is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Hesperidin Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Hesperidin drug interaction appears low for most people, since none of these interactions has been confirmed in humans. No interaction is rated major, and all of them are theoretical, resting on animal or lab research rather than proven effects in people.

Interactions deserving the most attention

The pairs that deserve the most attention involve blood pressure medications and blood thinners. Some human research shows hesperidin can lower blood pressure, so it could in theory add to the effect of antihypertensives, though other studies found no change. Animal research suggests hesperidin may have mild antiplatelet activity, which could add to bleeding risk with anticoagulant or antiplatelet drugs. Animal studies also show hesperidin can sharply change blood levels of verapamil and diltiazem, although this has not been seen in people.

What the rest of the list means

Most of the long list traces back to a single lab finding: hesperidin may block a transporter the body uses to clear many medications, which could raise their levels. That effect has not been shown to happen in people, so a listed interaction does not mean the combination is known to be harmful.

Check your medications against Hesperidin

Based on HelloPharmacist’s Hesperidin interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Hesperidin

703 medications have a known interaction with Hesperidin, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Hesperidin using our pharmacist-reviewed interaction data.

AI summaries are generated from our Hesperidin interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Hesperidin combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Hesperidin affects

Every type of medication (drug category) Hesperidin is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 7 drug categories Hesperidin interacts with

Anticoagulant/antiplatelet DrugsAntihypertensive DrugsCeliprolol (celicard)Cns DepressantsDiltiazem (cardizem, Others)P-glycoprotein SubstratesVerapamil (calan, Others)

Anticoagulant/Antiplatelet Drugs

Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Animal research suggests that hesperetin, a bioflavonoid aglycone derivative of hesperidin, may have antiplatelet activity.

Likelihood Possible Evidence D

Antihypertensive Drugs

Theoretically, taking hesperidin with antihypertensive drugs might increase the risk of hypotension.
Some clinical and animal research shows that hesperidin can decrease blood pressure. However, other clinical research shows that hesperidin does not affect blood pressure.

Likelihood Possible Evidence D

Celiprolol (Celicard)

Theoretically, hesperidin may decrease the levels and clinical effects of celiprolol.
Animal research shows that concomitant use of hesperidin may reduce the plasma area under the curve of celiprolol by up to 75%. This effect has not been reported in humans.

Likelihood Possible Evidence D

Cns Depressants

Theoretically, concomitant use with CNS depressants may cause additive sedative effects.
Animal studies show that hesperidin has sedative effects, due to opioid receptor activity and can increase sedation when used with diazepam. This effect has not been reported in humans.

Likelihood Possible Evidence D

Diltiazem (Cardizem, Others)

Theoretically, hesperidin may increase the levels and clinical effects of diltiazem.
Animal research suggests that hesperidin may enhance the bioavailability of diltiazem, increasing the plasma area under the curve of diltiazem by up to 65.3%. This effect has not been reported in humans.

Likelihood Possible Evidence D

P-Glycoprotein Substrates

Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of P-glycoprotein.
In vitro research shows that hesperidin can inhibit P-glycoprotein efflux. This effect has not been reported in humans.

Likelihood Possible Evidence D

Verapamil (Calan, Others)

Theoretically, hesperidin might increase the levels and clinical effects of verapamil.
Animal research suggests that hesperidin may enhance the bioavailability of verapamil, increasing the plasma area under the curve of verapamil by 96.8%. This effect has not been reported in humans

Likelihood Possible Evidence D

Monograph

Hesperidin: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed July 2026 ·

The bottom line

Hesperidin is a flavonoid found in citrus fruits that is often combined with diosmin and used for vein and circulation problems like hemorrhoids and varicose veins. Some evidence supports these uses, but data for many other claims is limited. It is generally well tolerated, but pregnant and breastfeeding people should avoid it because safety has not been established.

Family: Rutaceae
Part used: Fruit and peel of citrus fruits (especially oranges and lemons)
Common forms: Capsules, tablets, often combined with diosmin or vitamin C as a bioflavonoid complex

People commonly use it for

Hemorrhoids
Varicose veins and poor circulation
Leg swelling (venous insufficiency)
High blood pressure
Antioxidant support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Generally well tolerated in food amounts and short-term supplement use, but high-quality long-term data is limited.

PregnancyLikely Safe

When used orally in amounts found in foods.

Read the full pregnancy detail

BreastfeedingLikely Safe

When used orally in amounts found in foods.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Hesperidin is a natural plant compound called a flavonoid, often grouped with the "bioflavonoids." It is found in many plants but is especially concentrated in citrus fruits such as oranges, lemons, and tangerines, mostly in the peel and the white inner layer.

People take hesperidin as a dietary supplement, usually in capsules or tablets. It is often combined with another citrus flavonoid called diosmin, and sometimes with vitamin C, in products marketed for circulation and vein health. A modified, more water-soluble form called alpha-glucosyl hesperidin is also used in some supplements.

How it works

Hesperidin is an antioxidant, meaning it may help protect cells from damage by unstable molecules called free radicals. Much of this evidence comes from laboratory studies.

For vein health, researchers think hesperidin and related flavonoids may help strengthen blood vessel walls, reduce leakiness of small blood vessels, and lower inflammation. This is one proposed reason it may ease symptoms of hemorrhoids and varicose veins.

In lab and animal studies, hesperidin has also shown anti-inflammatory and possible blood-pressure and blood-sugar effects. These mechanisms are interesting but do not prove that the same effects happen reliably in people.

Effectiveness

Does Hesperidin work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by Dr. Brian Staiger, PharmD.

Evidence overview · 23 uses evaluated

1 Possibly effective 1 Leans ineffective 21 Insufficient evidence

How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.

2Likely EffectiveGood evidence, though not yet conclusive.

3Possibly EffectiveSome evidence suggests a benefit.

4Possibly IneffectiveSome evidence it may not help.

5Likely IneffectiveFairly strong evidence it doesn’t help.

6IneffectiveStrong evidence it doesn’t work.

7Insufficient Reliable Evidence to RateToo little research to say either way.

Possibly Effective Hypertriglyceridemia