Medication interaction hub

What Supplements Interact with Amobarbital, Ephedrine Sulfate?

Amobarbital, Ephedrine Sulfate brand name: Ephedrine & Amytal. Every interaction below applies to the brands too.

132 Interactions 10 Major 110 Moderate 12 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Amobarbital, Ephedrine Sulfate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Amobarbital, Ephedrine Sulfate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ephedrine & Amytal pairs a barbiturate sedative, amobarbital, with the stimulant ephedrine, so the supplements that interact with it pull in two directions at once, and I would treat this list with genuine care. Ten of the 132 ingredients on file are rated major: alcohol and kava can deepen the sedation toward dangerously slowed breathing, while ephedra piles extra strain on blood pressure and heart rate on top of the ephedrine already in the pill.

The typical collision is ordinary. Someone unwinding with a nightcap or kava tea, then running on caffeine all day, touches this list at both ends, and caffeine sources fill many of the 110 moderate slots. Unusual grogginess or shallow breathing points to the sedative side; a pounding heart or a blood pressure spike points to the stimulant side. Those two failure modes are the ones to know cold.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 110 Minor 12 No known interaction 1,320

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Amobarbital, Ephedrine Sulfate: Top Interactions at a Glance

The most significant Amobarbital, Ephedrine Sulfate supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 132 interacting ingredients — plus 1,320 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Amobarbital, Ephedrine Sulfate + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Amobarbital, Ephedrine Sulfatei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Amobarbital, Ephedrine Sulfatei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Amobarbital, Ephedrine Sulfatei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Ephedra + Amobarbital, Ephedrine Sulfatei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Amobarbital, Ephedrine Sulfatei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Amobarbital, Ephedrine Sulfatei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Amobarbital, Ephedrine Sulfate

All 1,452 ingredients in our database, ranked by severity — 132 with a Amobarbital, Ephedrine Sulfate interaction on file and 1,320 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Amobarbital, Ephedrine Sulfate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Glutamine with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glutamine might antagonize the effects of anticonvulsant medications.

Full Glutamine + Amobarbital, Ephedrine Sulfate answer

Can you take Kava with Amobarbital, Ephedrine Sulfate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Combining kava with CNS depressants can have additive sedative effects.

Full Kava + Amobarbital, Ephedrine Sulfate answer

Can you take Oregon Grape with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the sedative effects of CNS depressants.

Full Oregon Grape + Amobarbital, Ephedrine Sulfate answer

Can you take Shepherd's Purse with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Amobarbital, Ephedrine Sulfate answer

Can you take Skullcap with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Amobarbital, Ephedrine Sulfate answer

Can you take Spearmint with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Amobarbital, Ephedrine Sulfate answer

Can you take Tarragon with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Amobarbital, Ephedrine Sulfate answer

Can you take Theacrine with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Amobarbital, Ephedrine Sulfate answer

Can you take Thuja with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contain thujone, which might lower the seizure threshold.

Full Thuja + Amobarbital, Ephedrine Sulfate answer

Can you take Tianeptine with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Amobarbital, Ephedrine Sulfate answer

Can you take Tree Turmeric with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Full Tree Turmeric + Amobarbital, Ephedrine Sulfate answer

Can you take Valerian with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.

Full Valerian + Amobarbital, Ephedrine Sulfate answer

Can you take Wild Lettuce with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Full Wild Lettuce + Amobarbital, Ephedrine Sulfate answer

Can you take Wormwood with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.

Full Wormwood + Amobarbital, Ephedrine Sulfate answer

Can you take Yin Chen with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.

Full Yin Chen + Amobarbital, Ephedrine Sulfate answer

Can you take Yohimbe with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with stimulant drugs can have additive effects.

Full Yohimbe + Amobarbital, Ephedrine Sulfate answer

Can you take Zizyphus with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Full Zizyphus + Amobarbital, Ephedrine Sulfate answer

Can you take Lavender with Amobarbital, Ephedrine Sulfate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.

Full Lavender + Amobarbital, Ephedrine Sulfate answer

Can you take Calea Zacatechichi with Amobarbital, Ephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Calea zacatechichi might increase the sedative effects of CNS depressants.

Full Calea Zacatechichi + Amobarbital, Ephedrine Sulfate answer

Can you take N-methyltyramine with Amobarbital, Ephedrine Sulfate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. N-methyltyramine is thought to have stimulant effects.

Full N-methyltyramine + Amobarbital, Ephedrine Sulfate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Amobarbital, Ephedrine Sulfate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Amobarbital, Ephedrine Sulfate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Amobarbital, Ephedrine Sulfate sits in 5 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Amobarbital, Ephedrine Sulfate through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Amobarbital, Ephedrine Sulfate through this category.

Anticonvulsants 15 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

15 of the supplement ingredients on this page reach Amobarbital, Ephedrine Sulfate through this category.

Barbiturates 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Amobarbital, Ephedrine Sulfate through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Amobarbital, Ephedrine Sulfate through this category.

Related: does Amobarbital, Ephedrine Sulfate deplete any nutrients?

Amobarbital, Ephedrine Sulfate has 1 reported nutrient association in the research literature — see the Amobarbital, Ephedrine Sulfate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Amobarbital, Ephedrine Sulfate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Amobarbital, Ephedrine Sulfate.

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Products that contain Amobarbital, Ephedrine Sulfate-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Amobarbital, Ephedrine Sulfate.

Carda Lean by BS Supplements contains Ephedra Lean 40 by First Choice Supplements contains Ephedra Lipodrene with 25 mg Ephedra Extract by Hi-Tech Pharmaceuticals contains Ephedra Stimerex-ES by HTP Hi-Tech Pharmaceuticals contains Ephedra
Pharmacist Counseling Corner

Amobarbital, Ephedrine Sulfate & Supplements: Common Questions

What supplements interact with Amobarbital, Ephedrine Sulfate?
More than you might expect — 132 in total, though they are far from equal: 10 are rated major, 110 moderate, and 12 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Amobarbital, Ephedrine Sulfate supplement interactions are the most serious?
The 10 major-rated combinations — led by Beer, Wine, 1,4-butanediol, Ephedra and Gamma-hydroxybutyrate (ghb) — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Amobarbital, Ephedrine Sulfate?
Usually yes — most people on Amobarbital, Ephedrine Sulfate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Ephedrine & Amytal have the same supplement interactions as Amobarbital, Ephedrine Sulfate?
Yes — Ephedrine & Amytal all contain Amobarbital, Ephedrine Sulfate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Amobarbital, Ephedrine Sulfate deplete any vitamins or nutrients?
It might — Amobarbital, Ephedrine Sulfate has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Amobarbital, Ephedrine Sulfate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Amobarbital, Ephedrine Sulfate and my other medications?
This page covers Amobarbital, Ephedrine Sulfate against supplements and herbal ingredients. Checking Amobarbital, Ephedrine Sulfate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.