Medication interaction hub

What Supplements Interact with Conjugated Estrogens, Medroxyprogesterone Acetate?

Conjugated Estrogens, Medroxyprogesterone Acetate brand names: Prempro, Premplus. Every interaction below applies to the brands too.

187 Interactions 3 Major 152 Moderate 32 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Conjugated Estrogens, Medroxyprogesterone Acetate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Conjugated Estrogens, Medroxyprogesterone Acetate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

St. John's wort tops my list of concerns for anyone on Prempro (conjugated estrogens plus medroxyprogesterone), the combination hormone therapy for menopause symptoms. It revs up the liver enzyme that breaks down the estrogen, which can quietly undercut the treatment itself. Grapefruit does the opposite and raises hormone levels, while activated charcoal can block absorption outright. Those are the three major-rated entries among 187 ingredients on file, and they deserve genuine caution, not a shrug.

Most of the 152 moderate entries follow a few threads, with another 32 rated minor. Sixty ingredients have estrogen-like activity of their own, which can interfere with the very hormones you are taking. Estrogen also slows caffeine clearance, so coffee, tea, and guarana may feel stronger than usual. And bulky fibers such as glucomannan can trap an oral dose before it absorbs, so take them well apart from your Prempro dose.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 152 Minor 32 No known interaction 1,265

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Conjugated Estrogens, Medroxyprogesterone Acetate: Top Interactions at a Glance

The Conjugated Estrogens, Medroxyprogesterone Acetate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 187 interacting ingredients — plus 1,265 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Conjugated Estrogens, Medroxyprogesterone Acetate Combinations Today

The Conjugated Estrogens, Medroxyprogesterone Acetate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Vitamin C + Conjugated Estrogens, Medroxyprogesterone Acetatei

Vitamin C might increase blood levels of estrogens.

Read the full interaction Moderate Likelihood Possible Dhea + Conjugated Estrogens, Medroxyprogesterone Acetatei

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Hemp + Conjugated Estrogens, Medroxyprogesterone Acetatei

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Read the full interaction Major Likelihood Likely Grapefruit + Conjugated Estrogens, Medroxyprogesterone Acetatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Wild Yam + Conjugated Estrogens, Medroxyprogesterone Acetatei

Theoretically, wild yam might increase or decrease the effects of estrogen.

Read the full interaction Moderate Likelihood Possible Guar Gum + Conjugated Estrogens, Medroxyprogesterone Acetatei

Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Read the full interaction
The complete list

Every Supplement Checked Against Conjugated Estrogens, Medroxyprogesterone Acetate

All 1,452 ingredients in our database, ranked by severity — 187 with a Conjugated Estrogens, Medroxyprogesterone Acetate interaction on file and 1,265 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Conjugated Estrogens, Medroxyprogesterone Acetate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Vitamin C might increase blood levels of estrogens.

Full Vitamin C + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Dhea with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Hemp with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Grapefruit with Conjugated Estrogens, Medroxyprogesterone Acetate?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Wild Yam with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wild yam might increase or decrease the effects of estrogen.

Full Wild Yam + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Syrian Rue with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Syrian rue might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Syrian Rue + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Terminalia with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP3A4 substrates.

Full Terminalia + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Thunder God Vine with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Full Thunder God Vine + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Thyme with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.

Full Thyme + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Tragacanth with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Turmeric with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Full Turmeric + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Uva Ursi with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Valerian with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Vitamin E with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take White Pepper with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that piperine, a constituent of white pepper, inhibits cytochrome P450 3A4 (CYP3A4).

Full White Pepper + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Wild Cherry with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Zedoary with Conjugated Estrogens, Medroxyprogesterone Acetate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zedoary might increase levels of drugs metabolized by CYP3A4.

Full Zedoary + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Thyroid Extract with Conjugated Estrogens, Medroxyprogesterone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Acerola with Conjugated Estrogens, Medroxyprogesterone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of acerola with estrogens might increase estrogenic effects.

Full Acerola + Conjugated Estrogens, Medroxyprogesterone Acetate answer

Can you take Aegeline with Conjugated Estrogens, Medroxyprogesterone Acetate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Aegeline inhibits cytochrome P450 3A4 (CYP3A4) activity in vitro.

Full Aegeline + Conjugated Estrogens, Medroxyprogesterone Acetate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Conjugated Estrogens, Medroxyprogesterone Acetate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Conjugated Estrogens, Medroxyprogesterone Acetate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Conjugated Estrogens, Medroxyprogesterone Acetate sits in 7 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Conjugated Estrogens, Medroxyprogesterone Acetate through this category.

Related: does Conjugated Estrogens, Medroxyprogesterone Acetate deplete any nutrients?

Conjugated Estrogens, Medroxyprogesterone Acetate has 10 reported nutrient associations in the research literature — see the Conjugated Estrogens, Medroxyprogesterone Acetate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Conjugated Estrogens, Medroxyprogesterone Acetate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Conjugated Estrogens, Medroxyprogesterone Acetate.

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Pharmacist Counseling Corner

Conjugated Estrogens, Medroxyprogesterone Acetate & Supplements: Common Questions

What supplements interact with Conjugated Estrogens, Medroxyprogesterone Acetate?
Our database currently documents 187 ingredients with a known Conjugated Estrogens, Medroxyprogesterone Acetate interaction (3 major, 152 moderate, 32 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 187. The highest-ranked right now: Grapefruit, Activated Charcoal, St. John's Wort.
Which Conjugated Estrogens, Medroxyprogesterone Acetate supplement interactions are the most serious?
The 3 major-rated combinations — led by Grapefruit, Activated Charcoal and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Conjugated Estrogens, Medroxyprogesterone Acetate?
Plenty of supplements coexist fine with Conjugated Estrogens, Medroxyprogesterone Acetate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Prempro have the same supplement interactions as Conjugated Estrogens, Medroxyprogesterone Acetate?
Yes — Prempro, Premplus all contain Conjugated Estrogens, Medroxyprogesterone Acetate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Conjugated Estrogens, Medroxyprogesterone Acetate deplete any vitamins or nutrients?
It might — Conjugated Estrogens, Medroxyprogesterone Acetate has 10 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Conjugated Estrogens, Medroxyprogesterone Acetate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Conjugated Estrogens, Medroxyprogesterone Acetate and my other medications?
This page covers Conjugated Estrogens, Medroxyprogesterone Acetate against supplements and herbal ingredients. Checking Conjugated Estrogens, Medroxyprogesterone Acetate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.