Medication interaction hub

What Supplements Interact with Dextromethorphan, Guaifenesin, Phenylephrine?

Dextromethorphan, Guaifenesin, Phenylephrine brand names: Albatussin Sr, Giltuss. Every interaction below applies to the brands too.

197 Interactions 8 Major 148 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 20, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Dextromethorphan, Guaifenesin, Phenylephrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Dextromethorphan, Guaifenesin, Phenylephrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A combination cough medicine like dextromethorphan, guaifenesin, and phenylephrine (Albatussin Sr, Giltuss) deserves real care around supplements, not casual mixing. Of the 197 ingredients with an interaction on file, 8 carry a major rating, and those are the ones to understand first. The risk mostly runs along two lines: herbs that change how the body processes these drugs, so grapefruit can push levels up while St. John's wort can drop them, and stimulant ingredients like ephedra that pile onto phenylephrine's effect on blood pressure and heart rate.

The remaining 148 moderate and 41 minor entries mostly repeat those patterns at lower intensity. Everyday caffeine sources, coffee, tea, cocoa, add a mild stimulant load on top of the decongestant, and a smaller cluster boosts dextromethorphan's serotonin activity. Charcoal and thick fibers can blunt absorption, so keep them well apart from your dose.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 148 Minor 41 No known interaction 1,255

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Dextromethorphan, Guaifenesin, Phenylephrine: Top Interactions at a Glance

The most significant Dextromethorphan, Guaifenesin, Phenylephrine supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 197 interacting ingredients — plus 1,255 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Dextromethorphan, Guaifenesin, Phenylephrine + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Dextromethorphan, Guaifenesin, Phenylephrinei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable Activated Charcoal + Dextromethorphan, Guaifenesin, Phenylephrinei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Dextromethorphan, Guaifenesin, Phenylephrinei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction Major Likelihood Probable Lithium + Dextromethorphan, Guaifenesin, Phenylephrinei

Theoretically, taking lithium supplements with serotonergic drugs might both mask and increase the risk of serotonin syndrome.

Read the full interaction Major Likelihood Probable Peyote + Dextromethorphan, Guaifenesin, Phenylephrinei

Concomitant use of peyote with stimulant drugs may increase the risk of adverse CNS effects.

Read the full interaction Major Likelihood Probable Rauvolfia Vomitoria + Dextromethorphan, Guaifenesin, Phenylephrinei

Theoretically, concomitant use might cause additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Dextromethorphan, Guaifenesin, Phenylephrine

All 1,452 ingredients in our database, ranked by severity — 197 with a Dextromethorphan, Guaifenesin, Phenylephrine interaction on file and 1,255 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Dextromethorphan, Guaifenesin, Phenylephrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Moringa with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take N,n-dmpea with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that N,N-DMPEA strongly inhibits cytochrome P450 2D6 (CYP2D6).

Full N,n-dmpea + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Neem with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Oregon Grape with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP2D6.

Full Oregon Grape + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Padang Cassia with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that a methanol extract of Padang cassia inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full Padang Cassia + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Panax Ginseng with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Panax ginseng might increase levels of drugs metabolized by CYP2D6.

Full Panax Ginseng + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Peony with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Peony + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Peppermint with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, peppermint might increase the levels of CYP3A4 substrates.

Full Peppermint + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Phellodendron with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.

Full Phellodendron + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Phenethylamine (pea) with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining serotonergic drugs with phenethylamine might increase the risk of serotonergic adverse effects.

Full Phenethylamine (pea) + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Phenpromethamine with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Pomegranate with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.

Full Pomegranate + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Propolis with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.

Full Propolis + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Quercetin with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of CYP2D6 substrates.

Full Quercetin + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Rabdosia Rubescens with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that oridonin, a constituent of Rabdosia rubescens, induces cytochrome P450 3A4 (CYP3A4) enzyme.

Full Rabdosia Rubescens + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Raspberry Ketone with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Rauwolscine with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rauwolscine might increase levels of drugs metabolized by CYP2D6.

Full Rauwolscine + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Resveratrol with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.

Full Resveratrol + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Rooibos with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rooibos with CYP2D6 substrates may increase the effects of CYP2D6 substrates.

Full Rooibos + Dextromethorphan, Guaifenesin, Phenylephrine answer

Can you take Sage with Dextromethorphan, Guaifenesin, Phenylephrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Sage + Dextromethorphan, Guaifenesin, Phenylephrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Dextromethorphan, Guaifenesin, Phenylephrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Dextromethorphan, Guaifenesin, Phenylephrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Dextromethorphan, Guaifenesin, Phenylephrine sits in 8 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Alpha-Adrenergic Agonists 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Dextromethorphan, Guaifenesin, Phenylephrine through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Dextromethorphan, Guaifenesin, Phenylephrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Dextromethorphan, Guaifenesin, Phenylephrine.

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Pharmacist Counseling Corner

Dextromethorphan, Guaifenesin, Phenylephrine & Supplements: Common Questions

What supplements interact with Dextromethorphan, Guaifenesin, Phenylephrine?
Our database currently documents 197 ingredients with a known Dextromethorphan, Guaifenesin, Phenylephrine interaction (8 major, 148 moderate, 41 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 197. The highest-ranked right now: Grapefruit, Activated Charcoal, Ephedra.
Which Dextromethorphan, Guaifenesin, Phenylephrine supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Ephedra, Lithium and Peyote, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Dextromethorphan, Guaifenesin, Phenylephrine?
Plenty of supplements coexist fine with Dextromethorphan, Guaifenesin, Phenylephrine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Albatussin Sr have the same supplement interactions as Dextromethorphan, Guaifenesin, Phenylephrine?
Yes — Albatussin Sr, Giltuss all contain Dextromethorphan, Guaifenesin, Phenylephrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Dextromethorphan, Guaifenesin, Phenylephrine and my other medications?
This page covers Dextromethorphan, Guaifenesin, Phenylephrine against supplements and herbal ingredients. Checking Dextromethorphan, Guaifenesin, Phenylephrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 20, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.