Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Keep Calm Ingredients & Drug Interactions

by LifeBiome Rise

Keep Calm label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Keep Calm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Keep Calm is a dietary supplement by LifeBiome Rise with 4 active ingredients. Its ingredients are commonly taken for general nutrition and energy, skin and hair health, acne (topical and oral).Based on those ingredients, 1,434 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ashwagandha extract, Hemp Oil, Saffron extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Keep Calm by LifeBiome Rise

Ask about any prescription or over-the-counter medication and we check it for interactions with Keep Calm by LifeBiome Rise — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Keep Calm by LifeBiome Rise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “VidaSpheres Calming Blend” is a proprietary blend — the label gives one combined amount (155 mg) without saying how much of each component you get.

Keep Calm contains four active ingredients. Ashwagandha extract is an herbal supplement traditionally used to support calm and stress resilience.

Pantothenic acid is a B vitamin that your body needs for energy production and stress response. Saffron extract comes from the stigma (thread-like part) of the saffron flower and has been studied for effects on mood and cognition.

Hemp oil is derived from hemp seeds and contains fatty acids and other plant compounds. The product also includes inactive ingredients—hypromellose, microcrystalline cellulose, maltodextrin, copper chlorophyllin, and silica—which serve as capsule material, binders, and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: stress reduction and calm relaxation.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Fatigue, Chronic fatigue syndrome (CFS), Depression, stress management — and 2 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Stress.
  • Also on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Postpartum depression, Multiple sclerosis-related fatigue.

Ashwagandha is possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD). Evidence for its use in bipolar disorder is insufficient to rate.

Saffron extract is possibly effective for chemotherapy-induced peripheral neuropathy (nerve pain from cancer treatment) and Alzheimer disease. Pantothenic acid is effective for pantothenic acid deficiency, but evidence for other uses listed in the data (hay fever, alcoholism, hair loss) is insufficient or suggests it may be ineffective.

Hemp oil has insufficient evidence for the conditions listed in our data (constipation and eczema), so we don't know whether it works for those purposes.

The evidence, ingredient by ingredient Pantothenic Acid Hemp Ashwagandha Saffron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ashwagandha is generally well tolerated in the short term for healthy adults, though long-term safety data are limited. The most common side effects are diarrhea, nausea, vomiting, and gastrointestinal upset—though these don't occur often at typical doses.

Drowsiness has been reported. Serious but rare side effects include liver damage and a reversible brain blood-vessel condition.

Ashwagandha is not safe in pregnancy (traditionally thought to risk miscarriage) and there isn't enough safety information for breastfeeding, so avoid it during both. Pantothenic acid is considered safe at typical supplement doses with few side effects; diarrhea is the most commonly reported.

Saffron extract is likely safe in food amounts but should be used carefully at supplement doses, as high doses can be toxic. Common side effects include nausea, vomiting, gastrointestinal complaints, and sedation.

Rare serious side effects include anaphylaxis. Saffron is not safe in pregnancy (may stimulate the uterus) and there isn't enough reliable safety data for breastfeeding.

Hemp oil is generally well tolerated in food and larger amounts, though concentrated extracts are less studied. Rare serious side effects include anaphylaxis, allergic reactions, and in one case report, elevated liver enzymes.

Pregnancy and lactation safety data for hemp oil are not on file.

Side effects, ingredient by ingredient Pantothenic Acid Hemp Ashwagandha Saffron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Saffron, Ashwagandha, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,435 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Keep Calm, check with your doctor or pharmacist if you take any of the following: blood pressure medications (antihypertensive drugs), sedatives or sleep aids (CNS depressants), benzodiazepines like diazepam or lorazepam, diabetes medications (antidiabetes drugs), thyroid hormone, drugs that affect the liver (hepatotoxic drugs), blood thinners like warfarin (anticoagulants/antiplatelet drugs), hormone therapy or estrogen, ACE inhibitors for blood pressure, or immunosuppressants. Additionally, ashwagandha and saffron may affect how your liver processes caffeine, and ashwagandha and hemp may affect how your liver clears other medications via two major enzymes.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Keep Calm may appeal to you if you're looking to support calm and manage stress or mild anxiety, particularly through ashwagandha and saffron. However, this product has multiple documented interactions with blood pressure medications, blood thinners, diabetes drugs, sleep aids, sedatives, anxiety medications, and several other common medications, so you need to check your own medications before taking it.

If you're pregnant, breastfeeding, or taking any prescription drugs, talk with your doctor or pharmacist before starting—especially if you take thyroid medication, immunosuppressants, or drugs that stress the liver.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Keep Calm, straight from the product label.

Brand LifeBiome Rise
Barcode (UPC) 810047390299
Net contents 30 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 267541
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Keep Calm by LifeBiome Rise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegan Capsule(s)
Maximum serving Sizes:
1 Vegan Capsule(s)
Servings per container
30
UPC/BARCODE
810047390299
IngredientAmount% DV
Ashwagandha extract125 mg--
Pantothenic Acid30 mg600%
Saffron extract30 mg--
Hemp Oil300 mg--
VidaSpheres Calming Blend155 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Maltodextrin, Copper Chlorophyllin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Real. Clear. Easy

Using the science and technology of tomorrow to make staying healthy a little easier today.

Almost out? Call 1-888-303-7061 or visit healthydirections.com Choose refill & save, get free shipping forever

Formulation

Doctor-developed de-stressor for the daily zen you desire. Stress formula Calms an overactive mind to deliver deeper relaxation

Simple, science-backed, feel-good nutrition with vegan and non-GMO ingredients, including Sensoril ashwagandha, helps reduce fatigue and irritability and keeps you feeling calm and zen-like in times of stress.

Simple, science-backed, feel-good nutrition with vegan and non-GMO ingredients, including Sensoril ashwagandha, helps reduce fatigue and irritability and keeps you feeling calm and zen-like in times of stress. Dairy free Egg free Fish free Soy free Peanut free Shellfish free Gluten free

Vegan

Unconditionally guaranteed for purity and labeled potency.

Due to the nature of these ingredients, color variation over time may occur.

Formula

Concentrated microbeadlets in cold-pressed hemp seed oil

Simple, science-backed, feel-good nutrition with vegan and non-GMO ingredients, including Sensoril ashwagandha, helps reduce fatigue and irritability and keeps you feeling calm and zen-like in times of stress.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Doctor’s Suggested Use: Take 1 vegan capsule once daily. For added support, take 1 capsule twice daily.

Storage

To preserve quality and freshness, store box in a cool, dry place.

Precautions

Precautions: For adult use only at bedtime. Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Brand IP Statement(s)

Sensoril is a registered trademark of Natreon, Inc., and the product is protected under U.S. Patent No. 7,318,938 and CA Patent No. 2,508,478. VidaSpheres is licensed exclusively by Nutracode, LLC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Keep Calm by LifeBiome Rise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Keep Calm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Keep Calm by LifeBiome Rise

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegan Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pantothenic Acid

No known
interactions
30 mg per serving

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nea...

Pantothenic Acid monograph & interactions

Hemp Oil

Interacts with
938 drugs
300 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp Oil monograph & interactions

VidaSpheres Calming Blend

155 mg per serving

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Maltodextrin, Copper Chlorophyllin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Keep Calm by LifeBiome Rise Drug Interactions

Want to check YOUR meds against Keep Calm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,434Drugs
950 Moderate 484 Minor

Ingredients driving the most interactions

Ashwagandha extract 1,372
Hemp Oil 938
Saffron extract 521

Individual Drug Interactions

The ingredients in Keep Calm interact with 1,434 drugs. Click any drug to see the details.

3 of the 4 ingredients in Keep Calm interact with drugs. Each result below shows which ingredient is responsible. Ashwagandha extract Hemp Oil Saffron extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Keep Calm with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Ashwagandha extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Ashwagandha extract full monograph & interactions

Hemp Oil6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Oil full monograph & interactions

Saffron extract4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Keep Calm, from the product label.

LifeBiome Rise

See all LifeBiome Rise products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Web Address
www.healthydirections.com
Pharmacist Counseling Corner

Keep Calm by LifeBiome Rise: Common Questions

Does Keep Calm by LifeBiome Rise interact with any medications?
Yes. Based on its ingredients, Keep Calm has a known interaction with 1,434 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Keep Calm contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Keep Calm if I'm pregnant or breastfeeding?
Ashwagandha and saffron are not safe in pregnancy and may increase miscarriage risk. There isn't enough safety data for breastfeeding with ashwagandha or saffron, so avoid those during nursing. Pantothenic acid at normal dietary and prenatal-vitamin amounts is fine in pregnancy and lactation, but check with your doctor before taking high-dose supplements. Hemp oil safety data for pregnancy and breastfeeding are not on file—talk with your doctor.
What is hemp oil, and does it contain THC or CBD?
The product facts describe hemp oil as derived from hemp and list it as containing fatty acids and plant compounds. The data do not specify whether this product contains THC, CBD, or neither, so you should check the product label or contact the manufacturer for clarification.
What are the most common side effects?
Ashwagandha most commonly causes diarrhea, nausea, vomiting, and gastrointestinal upset at typical doses, though these are not frequent. Saffron may cause nausea, vomiting, gastrointestinal complaints, or sedation. Pantothenic acid may cause diarrhea. Drowsiness is possible with ashwagandha.
Is Keep Calm safe if I have liver disease?
Ashwagandha has been linked to cases of acute hepatitis and liver failure, so it should be used very carefully—or avoided—if you have liver disease or take drugs that stress the liver. Talk with your doctor or pharmacist before taking this product.
How much ashwagandha and saffron are in each capsule?
The product facts do not list the individual serving sizes for ashwagandha extract, saffron extract, or hemp oil. Check the product label on the bottle for the amount per capsule.
Will Keep Calm make me drowsy?
Ashwagandha and saffron both can cause drowsiness or sedation. If you're sensitive to sedative effects or need to stay alert, start with caution and avoid taking it before driving or operating machinery.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Keep Calm label
Go deeper

The Full Monographs Behind Keep Calm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantothenic Acid

Pantothenic acid is vitamin B5, an essential nutrient your body uses to turn food into energy. True deficiency is very rare because it is found in nearly all foods, and most people meet thei...

Read the full Pantothenic Acid monograph → Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph →
Sources

Sources & How We Checked

Keep Calm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 77 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ashwagandha 32 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Upton R, ed. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia 2000:1-25.
  3. Davis L, Kuttan G. Effect of Withania somnifera on cyclophosphamide-induced urotoxicity. Cancer Lett 2000;148:9-17. PubMed
  4. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. J Ethnopharmacol 1998;62:209-14. PubMed
  5. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev 2000;5:334-46. DOI
  6. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000;38:607-9.
  7. Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91-5. PubMed
  8. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Its effects on arterial blood pressure in anaesthetized dogs. Phytother Res 1991;5:111-14.
  9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999;67:233-39. PubMed
  10. Panda S, Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J Pharm Pharmacol 1998;50:1065-68. PubMed
  11. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Skinmed. 2012;10(1):48-49.
  12. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Indian J Pharmacol. 2013;45(4):417-8. PubMed
  13. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Integr Cancer Ther. 2013;12(4):312-22.
  14. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. J Altern Complement Med. 2018 Mar;24(3):243-248. PubMed
  15. Durg S, Bavage S, Shivaram SB. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytother Res. 2020;34(5):1041-1059.
  16. Björnsson HK, Björnsson ES, Avula B, et al. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. PubMed
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Saffron 22 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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