Major interaction on record — check this product against your medications before combining. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Spirodrene Ingredients & Drug Interactions

by EST Engineered Sports Technology

Spirodrene label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Spirodrene against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Spirodrene is a dietary supplement by EST Engineered Sports Technology with 6 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 1,439 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B3, Vitamin B, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Spirodrene by EST Engineered Sports Technology

Ask about any prescription or over-the-counter medication and we check it for interactions with Spirodrene by EST Engineered Sports Technology — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Spirodrene by EST Engineered Sports Technology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 15 active ingredients.
  • “4-Hydroxyphenylalanine” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Spirodrene Exclusive Blend” is a proprietary blend — the label gives one combined amount (580 mg) without saying how much of each component you get.
  • “Immediate Release” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Spirodrene contains 15 ingredients, including several actives: raspberry ketone, N-Acetyl L-Tyrosine, kelp, vitamin B12, di-caffeine malate, vitamin B3, yohimbine HCl, caffeine, 1,3-dimethylamylamine (DMAA), theobromine, L-tyrosine variants, vitamin B6, red tea, and white ginseng. Two inactive ingredients—stearic acid and magnesium stearate—are used as binding and flow agents in the tablet.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Neonatal apnea — rated "Effective" (Caffeine) (Natural Medicines).
  • On file: Phenylketonuria (PKU) — rated "Effective" (Tyrosine) (Natural Medicines).
  • On file: Postoperative headache — rated "Effective" (Caffeine) (Natural Medicines).

The evidence for most of Spirodrene's ingredients is limited or absent. Vitamin B12 is effective for B12 deficiency and likely effective for cyanide poisoning, and possibly effective for canker sores and nerve pain.

Caffeine (from both di-caffeine malate and caffeine) is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, likely effective for high homocysteine, and possibly effective for pregnancy-related nausea.

Tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, though possibly ineffective for athletic performance. For raspberry ketone, obesity, and alopecia areata, the data shows insufficient evidence to rate these claims.

The evidence for DMAA, yohimbine, and the other blend components is not established in our data.

The evidence, ingredient by ingredient Vitamin B12 Niacin Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of Spirodrene's ingredients are generally well tolerated in moderate amounts, but caffeine and DMAA carry serious cautions. Caffeine in high doses can cause anxiety, insomnia, tremors, nausea, and rarely stroke; DMAA is banned in many countries and linked to heart attack, stroke, heart rhythm problems, and severe lactic acidosis.

Raspberry ketone resembles a stimulant and case reports describe heart palpitations, high blood pressure, and in one case a life-threatening heart rhythm disturbance. Tyrosine at high doses may cause headache and fatigue; vitamin B6 at very high doses over time can damage nerves.

For pregnancy, the safety data advises against raspberry ketone and DMAA; caffeine, tyrosine, and B6 should be used only under a doctor's guidance; and vitamin B12 is safe at normal amounts. For breastfeeding, caffeine, tyrosine, and B6 require caution; raspberry ketone and DMAA should be avoided; and B12 is safe at recommended amounts.

We hold no pregnancy or breastfeeding safety data for N-Acetyl L-Tyrosine, kelp, vitamin B3, yohimbine, theobromine, red tea, or white ginseng.

Side effects, ingredient by ingredient Vitamin B12 Niacin Vitamin B6

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 10 of the 10 matched ingredients can interact with medications — Fucus Vesiculosus, Yohimbe, Cocoa, Niacin, Vitamin B12, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,440 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Spirodrene, check with your pharmacist or doctor if you take ephedrine or any stimulant drug (Major risk); warfarin or other blood thinners; pentobarbital, dipyridamole, clozapine, cimetidine, quinolone antibiotics (like ciprofloxacin), phenobarbital, or carbamazepine (Moderate risk); metformin for diabetes, levodopa for Parkinson's, thyroid hormones, antihypertensive (blood pressure) drugs, amiodarone, phenytoin, or any CYP2D6 substrate drugs like certain antidepressants or pain relievers (Moderate or Minor risk). No interactions are documented for the ingredients we could not fully check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Spirodrene is a complex multi-ingredient stimulant product with serious cardiovascular risks, especially for anyone taking heart or blood pressure medications, seizure drugs, or other stimulants. If you take warfarin, diabetes medication, Parkinson's meds, thyroid hormone, or any prescription drug, check your exact medications with the tool on this page before starting.

This is not a product to take without pharmacist or doctor review.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Spirodrene, straight from the product label.

Brand EST Engineered Sports Technology
Net contents 30 Spiro Tab(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 1963
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Spirodrene by EST Engineered Sports Technology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
IngredientAmount% DV
Raspberry Ketone0 NP--
N-Acetyl L-Tyrosine0 NP--
Kelp0 NP--
Vitamin B12200 mcg3333%
Di-Caffeine Malate0 NP--
Vitamin B310 mg50%
Yohimbine HCl0 NP--
Caffeine0 NP--
1,3 Dimethylamylamine0 NP--
Theobromine0 NP--
4-Hydroxyphenylalanine0 NP--
L-Tyrosine AKG0 NP--
L-Tyrosine Ethyl Ester0 NP--
Vitamin B25 mg1250%
Spirodrene Exclusive Blend580 mg--
Immediate Release0 NP--
Red Tea0 NP--
White Ginseng0 NP--
Secondary Release0 NP--
Thyro-T0 NP--

Other ingredients: Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

CAUTION: SPIRODRENE(TM) is highly potent. DO NOT consume more than ONE serving daily.

Do not exceed recommended dose.

Suggested Use: Take one Spiro Tab daily. Do not exceed more than one serving daily, as Spirodrene is highly potent. For best results, always remember to drink at least 64 oz. (8 glasses) of water daily.

General Statements

580 mg

Dual Staged Time Dispersed Delivery

ENGINEERED SPORTS TECHNOLOGY

ONE-A-DAY Technology

Promotes Lipolysis & Metabolic Rate May Support Proper Thyroid Function Promotes Body Fat Reduction via Multi-Receptor Activity Promotes Energy & Well-Being

Precautions

Consult your physician prior to use if you are pregnant or nursing, or if you are taking medications; including, but not limited to MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs, or other stimulants.

Consult your physician prior to use if you have a medical condition; including, but not limited to heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma. Discontinue two weeks prior to surgery or if you experience rapid heart beat, dizziness, severe headache, or shortness of breath.

Do not consume caffeine from other sources, including but not limited to; coffee, tea, soda, and other dietary supplements or medications containing phenylephrine or caffeine. Spirodrene(TM) contains caffeine and should not be taken by individuals wishing to eliminate this ingredient from their diet.

If you have difficulty sleeping, do not take after 4:00 PM. Healthy adults should cycle off this product after twelve weeks of use.

Warning: Not intended for use for persons under the age of 18.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Spirodrene by EST Engineered Sports Technology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Spirodrene label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Spirodrene by EST Engineered Sports Technology

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
200 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Vitamin B3

Interacts with
727 drugs
10 mg per serving Form: Niacin

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Vitamin B3 monograph & interactions

Vitamin B

Interacts with
210 drugs
25 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B monograph & interactions

Spirodrene Exclusive Blend

580 mg per serving
  • › Immediate Release
  • › Secondary Release
  • › Thyro-T

Other (inactive) ingredients: Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Spirodrene by EST Engineered Sports Technology Drug Interactions

Want to check YOUR meds against Spirodrene?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,439Drugs
17 Major 1,163 Moderate 259 Minor

Ingredients driving the most interactions

Vitamin B3 727
Vitamin B 210
Vitamin B12 20

Individual Drug Interactions

The ingredients in Spirodrene interact with 1,439 drugs. Click any drug to see the details.

3 of the 6 ingredients in Spirodrene interact with drugs. Each result below shows which ingredient is responsible. Vitamin B3 Vitamin B Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Spirodrene with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B315 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
Vitamin B3 full monograph & interactions

Vitamin B5 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Spirodrene, from the product label.

EST Engineered Sports Technology

See all EST Engineered Sports Technology products
Name
EST Engineered Sports Technology
Pharmacist Counseling Corner

Spirodrene by EST Engineered Sports Technology: Common Questions

Does Spirodrene by EST Engineered Sports Technology interact with any medications?
Yes. Based on its ingredients, Spirodrene has a known interaction with 1,439 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Spirodrene contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Spirodrene if I'm pregnant or breastfeeding?
No. Raspberry ketone and DMAA are unsafe in pregnancy and breastfeeding. Caffeine, tyrosine, and B6 require a doctor's approval at supplemental doses during pregnancy, and high doses of B6 should be avoided while breastfeeding. Talk to your OB or pediatrician before using any ingredient in this product.
What is DMAA and why is it a concern?
DMAA (1,3-dimethylamylamine) is a stimulant banned in many countries due to documented cases of heart attack, stroke, abnormal heart rhythms, and life-threatening acid buildup in the blood. It's tied to serious cardiovascular harm, especially when combined with other stimulants like caffeine.
Does this product help with weight loss or energy?
Caffeine is proven effective for mental alertness and likely effective for athletic performance. However, raspberry ketone and DMAA for weight loss have insufficient evidence or no established proof of benefit. The product's ability to deliver these outcomes is not well supported by the data we hold.
What are the most common side effects?
Caffeine commonly causes anxiety, insomnia, jitteriness, tremors, nausea, and headache. Raspberry ketone resembles a stimulant and can cause heart palpitations, high blood pressure, and shakiness. High doses of B6 over time can cause nerve damage. DMAA carries risk of serious heart and blood pressure problems.
Is this safe to take with my blood pressure medication?
Not without checking first. Caffeine, DMAA, and raspberry ketone are all stimulants that raise blood pressure. Vitamin B6 may add to the blood-pressure-lowering effect of your medication. Use the medication checker on this page to verify your exact drug, or talk to your pharmacist.
What inactive ingredients are in Spirodrene?
The product contains stearic acid and magnesium stearate, which are binding and flow agents used to make the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Spirodrene label
Go deeper

The Full Monographs Behind Spirodrene’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Niacin

Interacts with 727 drugs

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescription-strength niacin has been used to...

Read the full Niacin monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

Spirodrene's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 593 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Raspberry Ketone 4 references
  1. Adverse Event Report. Raspberry Ketone. Natural MedWatch, April 27, 2012.
  2. Adverse Event Report. Raspberry Ketone. Natural MedWatch, September 18, 2011.
  3. Ansari SA, Patel F, Ashouri D, Dhaliwal JSS, Desai A. Resistant Polymorphic Ventricular Tachycardia in a Patient Taking Raspberry Ketones Weight Loss Supplement. Cureus 2022;14(12):e33089. PubMed
  4. Khattar A, Beeton I. Coronary vasospasm and raspberry ketones weight-loss supplement: Is there a connection? Anatol J Cardiol. 2020;24(3):205-208.

See these in context on the Raspberry Ketone monograph →

Fucus Vesiculosus 15 references
  1. Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Phaneuf D, Cote I, Dumas P, et al. Evaluation of the contamination of marine algae (Seaweed) from the St. Lawrence River and likely to be consumed by humans. Environ Res 1999;80:S175-S182. PubMed
  4. Durig J, Bruhn T, Zurborn KH, et al. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 1997;85:479-91. PubMed
  5. Conz PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: a nephrotoxic alga? Nephrol Dial Transplant 1998;13:526-7.
  6. Ohye H, Fukata S, Kanoh M, et al. Thyrotoxicosis caused by weight-reducing herbal medicines. Arch Intern Med 2005;165:831-4. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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