Chlorpromazine

89 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Nasal Spray Metoclopramide Injection Glucagon Injection / Solution Dofetilide Levofloxacin Injection Foscarnet Injection
2 Contraindicated 82 Major 5 Moderate
All (89) Contraindicated (2) Major (82) Moderate (5)

Contraindicated

Chlorpromazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Chlorpromazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Chlorpromazine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Chlorpromazine Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Chlorpromazine Sertraline Explained An increased risk of QT interval prolongation Details Chlorpromazine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of CNS and respiratory depression and an increased risk of paraly... Details Chlorpromazine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Chlorpromazine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Chlorpromazine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Chlorpromazine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Chlorpromazine Azithromycin AzaSite An increased risk of QT interval prolongation Details Chlorpromazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Chlorpromazine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Chlorpromazine Anagrelide Agrylin Increased risk of QT interval prolongation Details Chlorpromazine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Chlorpromazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Chlorpromazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Chlorpromazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Chlorpromazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Chlorpromazine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Dasatinib Phyrago An increased risk of QT interval prolongation Details Chlorpromazine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Chlorpromazine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Chlorpromazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Chlorpromazine Diazepam Rectal Diastat Increased risk of CNS depression Details Chlorpromazine Disopyramide Norpace An increased risk of QT interval prolongation Details Chlorpromazine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Dolasetron Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Dolasetron Injection Anzemet Cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Chlorpromazine Encorafenib Braftovi Increased risk of QT interval prolongation Details Chlorpromazine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Chlorpromazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Chlorpromazine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Chlorpromazine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chlorpromazine Fostemsavir Rukobia Increased risk of torsade de pointes Details Chlorpromazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.