Mavacamten

Contraindicated

Mavacamten Encorafenib Braftovi Reduced mavacamten exposure, reduced efficacy of mavacamten, reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 subs... Details Mavacamten Mitapivat Aqvesme Reduced mavacamten exposure, reduced efficacy of mavacamten, reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 subs... Details Mavacamten Nafcillin Injection Unipen® Injection Reduced mavacamten exposure and reduced efficacy of mavacamten Details

Major

Mavacamten Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Mavacamten Omeprazole Gastrobim Explained Increased mavacamten exposure, an increased risk of mavacamten-related adverse reactions, reduced omeprazole exposure and reduced... Details Mavacamten Abrocitinib Cibinqo Explained Increased mavacamten exposure, an increased risk of mavacamten-related adverse reactions, reduced abrocitinib exposure and reduced... Details Mavacamten Asciminib Scemblix Increased mavacamten exposure, an increased risk of mavacamten-related adverse effects, reduced CYP3A4 substrate exposure and redu... Details Mavacamten Clopidogrel Plavix Increased mavacamten exposure, an increased risk of mavacamten-related adverse effects, reduced clopidogrel exposure and reduced e... Details Mavacamten Disopyramide Norpace An increased risk of additive inotropic effects and reduced cardiac contractility Details Mavacamten Enasidenib Idhifa Increased mavacamten exposure and an increased risk of mavacamten-related adverse effects Details Mavacamten Esomeprazole Nexium Increased mavacamten exposure, an increased risk of mavacamten-related adverse reactions, reduced esomeprazole exposure and reduce... Details Mavacamten Esomeprazole Injection Nexium Increased mavacamten exposure, an increased risk of mavacamten-related adverse reactions, reduced esomeprazole exposure and reduce... Details Mavacamten Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Felbamate Felbatol Increased mavacamten exposure and an increased risk of mavacamten-related adverse effects Details Mavacamten Ketoconazole Topical Extina® Foam Increased mavacamten exposure which may increase the risk of heart failure, reduced CYP3A4 substrate exposure and reduced efficacy... Details Mavacamten Lefamulin Xenleta Increased mavacamten exposure, an increased risk of mavacamten-related adverse effects, reduced CYP3A4 substrate exposure and redu... Details Mavacamten Lenacapavir Injection Sunlenca Increased mavacamten exposure, an increased risk of mavacamten-related adverse effects, reduced CYP3A4 substrate exposure and redu... Details Mavacamten Lenacapavir Oral Sunlenca Increased mavacamten exposure, an increased risk of mavacamten-related adverse effects, reduced CYP3A4 substrate exposure and redu... Details Mavacamten Letermovir Injection Prevymis Increased mavacamten exposure and an increased risk of mavacamten-related adverse effects Details Mavacamten Levonorgestrel After banger Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Levonorgestrel Intrauterine System Kyleena Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased mavacamten exposure and an increase... Details Mavacamten Nifedipine Adalat® Reduced NIFEdipine exposure Details Mavacamten Obeticholic Acid Ocaliva Increased mavacamten exposure and an increased risk of mavacamten-related adverse effects Details

Moderate

Mavacamten Clindamycin ANTIROBE Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Sertraline Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Buprenorphine Belbuca Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Colchicine Colcrys Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Simvastatin Flolipid Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Abemaciclib Verzenio Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Acalabrutinib Calquence Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Alpelisib Piqray Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Apixaban Eliquis Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Aripiprazole Injection Abilify Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Atogepant Qulipta Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Avapritinib Ayvakit Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Mavacamten Avatrombopag Doptelet Reduced CYP3A4/CYP2C9 substrate exposure and reduced efficacy of CYP3A4/CYP2C9 substrate Details