Drug Interactions Directory

2,618 drugs with documented interactions.

2,618Drugs
67,117Interactions
53,805Serious (major+)
PharmacistReviewed
1Look up a drugSearch by generic or brand name, or browse A-Z.
2Scan the severityInteractions are grouped and color-coded by how much they matter.
3Read the write-upPlain-English and clinical explanations, with cited evidence.
Popular: Buprenorphine 633 Hydroxychloroquine 631 Ketoconazole Topical 546 Cyclosporine Injection 545 Cyclosporine Ophthalmic 545 Sertraline 532 Amitriptyline 525 Fentanyl Transdermal Patch 493

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

H
Homatropine 12 Horse Chestnut 4 Horsetail 2 Human Papillomavirus Vaccine 2 Hyaluronidase 1 Hydralazine 12 Hydrastis 3 Hydrochlorothiazide 89 Hydrocodone 56 Hydrocortisone 439 Hydrocortisone Injection 393 Hydroflumethiazide 66 Hydromorphone 43 Hydromorphone Injection 344 Hydromorphone Rectal 344 Hydroquinidine 51 Hydroxyamphetamine 15 Hydroxychloroquine 631 Hydroxytryptophan 18 Hydroxyurea 28 Hydroxyzine 87 Hyoscyamine 12
I
Ibalizumab-Uiyk 1 Ibalizumab-Uiyk Injection 3 Ibandronate 12 Ibandronate Injection 12 Ibrexafungerp 111 Ibritumomab Injection 55 Ibritumomab Tiuxetan 15 Ibrutinib 149 Ibuprofen 302 Ibuprofen Lysine 8 Ibutilide 59 Icatibant 7 Icosapent Ethyl 46 Idarubicin 24 Idecabtagene Vicleucel Injection 15 Idelalisib 91 Ifosfamide 10 Ifosfamide Injection 98 Iloperidone 69 Iloprost 172 Imatinib 79 Imidapril 5 Imipenem 6 Imipramine 111 Imlunestrant 7 Immune Globulin 1 Inamrinone 1 Indacaterol 11 Indacaterol Oral Inhalation 34 Indalpine 1 Indapamide 102 Indecainide 2 Indinavir 123 Indomethacin 95 Infigratinib 118 Infliximab 21 Influenza Virus Vaccine 11 Influenza Virus Vaccine, Live 200 Inotersen 38 Inotuzumab Ozogamicin 62 Inotuzumab Ozogamicin Injection 225 Insulin 130 Insulin Aspart, Recombinant 134 Insulin Bovine 64 Insulin Degludec 75 Insulin Degludec (Rdna Origin) Injection 166 Insulin Detemir 75 Insulin Detemir (Rdna Origin) Injection 166 Insulin Glargine, Recombinant 117 Insulin Glulisine 75 Insulin Glulisine (Rdna Origin) Injection 174 Insulin Human Inhaled 11 Insulin Human Isophane (Nph) 11 Insulin Human Regular 11 Insulin Icodec-Abae 113 Insulin Lispro, Recombinant 128 Interferon Alfa 1 Interferon Alfa-2A 3 Interferon Alfa-2B 1 Interferon Alfa-2B Injection 13 Interferon Beta 2 Interferon Beta-1A 4 Interferon Beta-1A Intramuscular Injection 5 Interferon Beta-1A Subcutaneous Injection 5 Interferon Beta-1B 4 Interferon Beta-1B Injection 4 Interferon Gamma-1B Injection 15 Iobenguane I 123 6 Iobenguane I 131 14 Iodipamide 1 Iodixanol 1 Ioflupane I 123 3 Iohexol 12 Iomeprol 3 Iomeprol Injection 3 Iopamidol 1 Iopanoic Acid 2 Iopromide 3 Iothalamate 1 Iotrolan 1 Ioversol 1 Ioxaglate 1 Ipilimumab Injection 15 Ipodate 1 Ipratropium 10 Ipratropium Nasal Spray 41 Ipratropium Oral Inhalation 41 Iprindole 1 Iproniazid 14 Iptacopan 1 Irbesartan 146 Irinotecan 98 Irinotecan Injection 96 Irinotecan Lipid Complex Injection 73 Irinotecan Liposome 4 Iron 37 Iron Dextran 1 Iron Sucrose 1